Different Disclosed Probabilities to Receive an Antiemetic Equally Decrease Subjective Symptoms in an Experimental Placebo Study: To Be or Not to Be Sure

Katja Weimer; Björn Horing; Eric R Muth; Jenna L Scisco; Sibylle Klosterhalfen; Paul Enck

doi:10.1016/j.clinthera.2016.11.022

Different Disclosed Probabilities to Receive an Antiemetic Equally Decrease Subjective Symptoms in an Experimental Placebo Study

Standard

Different Disclosed Probabilities to Receive an Antiemetic Equally Decrease Subjective Symptoms in an Experimental Placebo Study : To Be or Not to Be Sure. / Weimer, Katja; Horing, Björn; Muth, Eric R; Scisco, Jenna L; Klosterhalfen, Sibylle; Enck, Paul.

In: CLIN THER, Vol. 39, No. 3, 03.2017, p. 487-501.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Weimer, K, Horing, B, Muth, ER, Scisco, JL, Klosterhalfen, S & Enck, P 2017, 'Different Disclosed Probabilities to Receive an Antiemetic Equally Decrease Subjective Symptoms in an Experimental Placebo Study: To Be or Not to Be Sure', CLIN THER, vol. 39, no. 3, pp. 487-501. https://doi.org/10.1016/j.clinthera.2016.11.022

APA

Weimer, K., Horing, B., Muth, E. R., Scisco, J. L., Klosterhalfen, S., & Enck, P. (2017). Different Disclosed Probabilities to Receive an Antiemetic Equally Decrease Subjective Symptoms in an Experimental Placebo Study: To Be or Not to Be Sure. CLIN THER, 39(3), 487-501. https://doi.org/10.1016/j.clinthera.2016.11.022

Vancouver

Weimer K, Horing B, Muth ER, Scisco JL, Klosterhalfen S, Enck P. Different Disclosed Probabilities to Receive an Antiemetic Equally Decrease Subjective Symptoms in an Experimental Placebo Study: To Be or Not to Be Sure. CLIN THER. 2017 Mar;39(3):487-501. https://doi.org/10.1016/j.clinthera.2016.11.022

Bibtex

@article{fe14c27800644de093bc4b02b0b8cf22,

title = "Different Disclosed Probabilities to Receive an Antiemetic Equally Decrease Subjective Symptoms in an Experimental Placebo Study: To Be or Not to Be Sure",

abstract = "PURPOSE: The purpose of this study was to examine whether the disclosed probability of receiving an antiemetic affects nausea.METHODS: Forty-eight healthy participants (mean [SD] age, 26.8 [5.4] years; 50% female) were exposed to 5 × 2 minutes of nauseogenic body rotations on 2 days. On day 2, participants were randomized to 3 experimental groups that were given different instructions concerning the probability of receiving an antiemetic remedy (100%, 50%, or 0% probability), whereas all received an inert substance. Subjective symptoms, behavioral (rotation tolerance) measures, and physiologic (electrogastrogram) measures of nausea were assessed and mediator and moderator analyses performed for effects of expectations and psychological characteristics on outcomes.FINDINGS: Disclosed probabilities of both 100% and 50% significantly reduced subjective symptoms of nausea in an equal manner compared with the 0% probability group from day 1 to day 2. This effect was found for neither rotation tolerance nor myoelectric gastric activity. Expectations and psychological characteristics did not affect the results found. Post hoc analyses revealed that women only seem to be susceptible to this placebo effect.IMPLICATIONS: Nausea is susceptible to placebo effects independent of the disclosed probability of receiving a drug and of explicit expectations. In line with placebo research, this effect is probably attributable to central mechanisms, and it is speculated that it could be related to the reward circuitry and social interactions.",

keywords = "Adult, Antiemetics, Female, Humans, Male, Nausea, Placebo Effect, Probability, Rotation, Young Adult, Journal Article, Randomized Controlled Trial",

author = "Katja Weimer and Bj{\"o}rn Horing and Muth, {Eric R} and Scisco, {Jenna L} and Sibylle Klosterhalfen and Paul Enck",

year = "2017",

month = mar,

doi = "10.1016/j.clinthera.2016.11.022",

language = "English",

volume = "39",

pages = "487--501",

journal = "CLIN THER",

issn = "0149-2918",

publisher = "Excerpta Medica",

number = "3",

}

RIS

TY - JOUR

T1 - Different Disclosed Probabilities to Receive an Antiemetic Equally Decrease Subjective Symptoms in an Experimental Placebo Study

T2 - To Be or Not to Be Sure

AU - Weimer, Katja

AU - Horing, Björn

AU - Muth, Eric R

AU - Scisco, Jenna L

AU - Klosterhalfen, Sibylle

AU - Enck, Paul

PY - 2017/3

Y1 - 2017/3

N2 - PURPOSE: The purpose of this study was to examine whether the disclosed probability of receiving an antiemetic affects nausea.METHODS: Forty-eight healthy participants (mean [SD] age, 26.8 [5.4] years; 50% female) were exposed to 5 × 2 minutes of nauseogenic body rotations on 2 days. On day 2, participants were randomized to 3 experimental groups that were given different instructions concerning the probability of receiving an antiemetic remedy (100%, 50%, or 0% probability), whereas all received an inert substance. Subjective symptoms, behavioral (rotation tolerance) measures, and physiologic (electrogastrogram) measures of nausea were assessed and mediator and moderator analyses performed for effects of expectations and psychological characteristics on outcomes.FINDINGS: Disclosed probabilities of both 100% and 50% significantly reduced subjective symptoms of nausea in an equal manner compared with the 0% probability group from day 1 to day 2. This effect was found for neither rotation tolerance nor myoelectric gastric activity. Expectations and psychological characteristics did not affect the results found. Post hoc analyses revealed that women only seem to be susceptible to this placebo effect.IMPLICATIONS: Nausea is susceptible to placebo effects independent of the disclosed probability of receiving a drug and of explicit expectations. In line with placebo research, this effect is probably attributable to central mechanisms, and it is speculated that it could be related to the reward circuitry and social interactions.

AB - PURPOSE: The purpose of this study was to examine whether the disclosed probability of receiving an antiemetic affects nausea.METHODS: Forty-eight healthy participants (mean [SD] age, 26.8 [5.4] years; 50% female) were exposed to 5 × 2 minutes of nauseogenic body rotations on 2 days. On day 2, participants were randomized to 3 experimental groups that were given different instructions concerning the probability of receiving an antiemetic remedy (100%, 50%, or 0% probability), whereas all received an inert substance. Subjective symptoms, behavioral (rotation tolerance) measures, and physiologic (electrogastrogram) measures of nausea were assessed and mediator and moderator analyses performed for effects of expectations and psychological characteristics on outcomes.FINDINGS: Disclosed probabilities of both 100% and 50% significantly reduced subjective symptoms of nausea in an equal manner compared with the 0% probability group from day 1 to day 2. This effect was found for neither rotation tolerance nor myoelectric gastric activity. Expectations and psychological characteristics did not affect the results found. Post hoc analyses revealed that women only seem to be susceptible to this placebo effect.IMPLICATIONS: Nausea is susceptible to placebo effects independent of the disclosed probability of receiving a drug and of explicit expectations. In line with placebo research, this effect is probably attributable to central mechanisms, and it is speculated that it could be related to the reward circuitry and social interactions.

KW - Adult

KW - Antiemetics

KW - Female

KW - Humans

KW - Male

KW - Nausea

KW - Placebo Effect

KW - Probability

KW - Rotation

KW - Young Adult

KW - Journal Article

KW - Randomized Controlled Trial

U2 - 10.1016/j.clinthera.2016.11.022

DO - 10.1016/j.clinthera.2016.11.022

M3 - SCORING: Journal article

C2 - 28011248

VL - 39

SP - 487

EP - 501

JO - CLIN THER

JF - CLIN THER

SN - 0149-2918

IS - 3

ER -