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Different binding pattern of antibodies to prion protein on lymphocytes from patients with sporadic Creutzfeldt-Jakob disease.

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Different binding pattern of antibodies to prion protein on lymphocytes from patients with sporadic Creutzfeldt-Jakob disease. / Ratzka, Peter; Döhlinger, Susanne; Cepek, Lukas; Steinacker, Petra; Arlt, Sönke; Jacobi, Christian; Schröter, Andreas; Wiltfang, Jens; Prange, Hilmar; Kretzschmar, Hans A; Poser, Sigrid; Otto, Markus.

In: NEUROSCI LETT, Vol. 343, No. 1, 1, 2003, p. 29-32.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Ratzka, P, Döhlinger, S, Cepek, L, Steinacker, P, Arlt, S, Jacobi, C, Schröter, A, Wiltfang, J, Prange, H, Kretzschmar, HA, Poser, S & Otto, M 2003, 'Different binding pattern of antibodies to prion protein on lymphocytes from patients with sporadic Creutzfeldt-Jakob disease.', NEUROSCI LETT, vol. 343, no. 1, 1, pp. 29-32. <http://www.ncbi.nlm.nih.gov/pubmed/12749990?dopt=Citation>

APA

Ratzka, P., Döhlinger, S., Cepek, L., Steinacker, P., Arlt, S., Jacobi, C., Schröter, A., Wiltfang, J., Prange, H., Kretzschmar, H. A., Poser, S., & Otto, M. (2003). Different binding pattern of antibodies to prion protein on lymphocytes from patients with sporadic Creutzfeldt-Jakob disease. NEUROSCI LETT, 343(1), 29-32. [1]. http://www.ncbi.nlm.nih.gov/pubmed/12749990?dopt=Citation

Vancouver

Ratzka P, Döhlinger S, Cepek L, Steinacker P, Arlt S, Jacobi C et al. Different binding pattern of antibodies to prion protein on lymphocytes from patients with sporadic Creutzfeldt-Jakob disease. NEUROSCI LETT. 2003;343(1):29-32. 1.

Bibtex

@article{af431767bcbe4d7bbc7f36303c8f67a1,
title = "Different binding pattern of antibodies to prion protein on lymphocytes from patients with sporadic Creutzfeldt-Jakob disease.",
abstract = "In Creutzfeldt-Jakob disease (CJD), progressive neuronal cell death probably occurs as a result of a change in conformation of the physiological prion protein (PrP(C)). There is evidence of participation of the lymphatic system and in particular of lymphocytes in the intracorporeal transportation of the pathological prion protein (PrP(Sc)) in new variant CJD and scrapie. Using fluorescence cytometry, we investigated a possible alteration of PrP(C) on lymphocytes of patients with sporadic CJD. We demonstrated a significantly lower binding pattern of antibodies (3F4) against physiological prion protein to lymphocytes of patients with sporadic CJD (n=16) compared with control patients. In contrast this difference was not found on platelets (n=23). For the first time we were able to present a measurable difference of antibody binding on lymphocytes of patients with CJD. One interpretation of this finding is that lymphocytes patrolling the brain bind and transport PrP(Sc) which has a lower binding affinity for the antibodies directed against physiological PrP.",
author = "Peter Ratzka and Susanne D{\"o}hlinger and Lukas Cepek and Petra Steinacker and S{\"o}nke Arlt and Christian Jacobi and Andreas Schr{\"o}ter and Jens Wiltfang and Hilmar Prange and Kretzschmar, {Hans A} and Sigrid Poser and Markus Otto",
year = "2003",
language = "Deutsch",
volume = "343",
pages = "29--32",
journal = "NEUROSCI LETT",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

RIS

TY - JOUR

T1 - Different binding pattern of antibodies to prion protein on lymphocytes from patients with sporadic Creutzfeldt-Jakob disease.

AU - Ratzka, Peter

AU - Döhlinger, Susanne

AU - Cepek, Lukas

AU - Steinacker, Petra

AU - Arlt, Sönke

AU - Jacobi, Christian

AU - Schröter, Andreas

AU - Wiltfang, Jens

AU - Prange, Hilmar

AU - Kretzschmar, Hans A

AU - Poser, Sigrid

AU - Otto, Markus

PY - 2003

Y1 - 2003

N2 - In Creutzfeldt-Jakob disease (CJD), progressive neuronal cell death probably occurs as a result of a change in conformation of the physiological prion protein (PrP(C)). There is evidence of participation of the lymphatic system and in particular of lymphocytes in the intracorporeal transportation of the pathological prion protein (PrP(Sc)) in new variant CJD and scrapie. Using fluorescence cytometry, we investigated a possible alteration of PrP(C) on lymphocytes of patients with sporadic CJD. We demonstrated a significantly lower binding pattern of antibodies (3F4) against physiological prion protein to lymphocytes of patients with sporadic CJD (n=16) compared with control patients. In contrast this difference was not found on platelets (n=23). For the first time we were able to present a measurable difference of antibody binding on lymphocytes of patients with CJD. One interpretation of this finding is that lymphocytes patrolling the brain bind and transport PrP(Sc) which has a lower binding affinity for the antibodies directed against physiological PrP.

AB - In Creutzfeldt-Jakob disease (CJD), progressive neuronal cell death probably occurs as a result of a change in conformation of the physiological prion protein (PrP(C)). There is evidence of participation of the lymphatic system and in particular of lymphocytes in the intracorporeal transportation of the pathological prion protein (PrP(Sc)) in new variant CJD and scrapie. Using fluorescence cytometry, we investigated a possible alteration of PrP(C) on lymphocytes of patients with sporadic CJD. We demonstrated a significantly lower binding pattern of antibodies (3F4) against physiological prion protein to lymphocytes of patients with sporadic CJD (n=16) compared with control patients. In contrast this difference was not found on platelets (n=23). For the first time we were able to present a measurable difference of antibody binding on lymphocytes of patients with CJD. One interpretation of this finding is that lymphocytes patrolling the brain bind and transport PrP(Sc) which has a lower binding affinity for the antibodies directed against physiological PrP.

M3 - SCORING: Zeitschriftenaufsatz

VL - 343

SP - 29

EP - 32

JO - NEUROSCI LETT

JF - NEUROSCI LETT

SN - 0304-3940

IS - 1

M1 - 1

ER -