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Differences in diffusion tensor imaging changes between narcolepsy with and without cataplexy

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Differences in diffusion tensor imaging changes between narcolepsy with and without cataplexy. / Tezer, F Irsel; Erdal, Abidin; Gumusyayla, Sadiye; Has, Arzu Ceylan; Gocmen, Rahsan; Oguz, Kader K.

In: SLEEP MED, Vol. 52, 12.2018, p. 128-133.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Tezer, FI, Erdal, A, Gumusyayla, S, Has, AC, Gocmen, R & Oguz, KK 2018, 'Differences in diffusion tensor imaging changes between narcolepsy with and without cataplexy', SLEEP MED, vol. 52, pp. 128-133. https://doi.org/10.1016/j.sleep.2018.08.022

APA

Tezer, F. I., Erdal, A., Gumusyayla, S., Has, A. C., Gocmen, R., & Oguz, K. K. (2018). Differences in diffusion tensor imaging changes between narcolepsy with and without cataplexy. SLEEP MED, 52, 128-133. https://doi.org/10.1016/j.sleep.2018.08.022

Vancouver

Tezer FI, Erdal A, Gumusyayla S, Has AC, Gocmen R, Oguz KK. Differences in diffusion tensor imaging changes between narcolepsy with and without cataplexy. SLEEP MED. 2018 Dec;52:128-133. https://doi.org/10.1016/j.sleep.2018.08.022

Bibtex

@article{eb4b538efad94e369263cdac99c25730,
title = "Differences in diffusion tensor imaging changes between narcolepsy with and without cataplexy",
abstract = "OBJECTIVE: The distinctive clinical finding of Type 1 narcolepsy compared to Type 2 is the presence of cataplexy. Several neuroimaging studies have also reported abnormalities in narcolepsy patients with or without cataplexy. However, there are conflicting results to differentiate them. In this study, we aimed to clarify the white matter changes in narcolepsy patients both with and without cataplexy and compared them with healthy adults to evaluate microstructural differences in the brain.METHODS: Eleven narcolepsy patients with cataplexy (NC), 12 narcolepsy patients without cataplexy (NOC) and healthy age- and gender-matched controls (N = 16) were studied. Whole-brain diffusion tensor imaging (DTI) was obtained and tract-based spatial statistics were used to localize white matter abnormalities.RESULTS: Compared with the healthy controls, both NC and NOC patients exhibited significant fractional anisotropy (FA) decreases in the bilateral cerebellar hemispheres, bilateral thalami, the corpus callosum and left anterior-medial temporal white matter. Compared with the controls, the NC patients' FA values were also decreased in the midbrain. No significant correlations were found between FA values and clinical-polysomnographic variables.CONCLUSION: This DTI study has demonstrated white matter abnormalities in the midbrain-brainstem regions as a distinctive finding of narcolepsy patients with cataplexy. Involvement of bilateral temporal lobes with greater changes on the left lobe is also a supporting finding of patients with cataplexy. DTI changes in the midbrain-brainstem and bilateral temporal lobes can be signs of different pathological mechanisms in these patients.",
keywords = "Journal Article",
author = "Tezer, {F Irsel} and Abidin Erdal and Sadiye Gumusyayla and Has, {Arzu Ceylan} and Rahsan Gocmen and Oguz, {Kader K}",
note = "Copyright {\textcopyright} 2018 Elsevier B.V. All rights reserved.",
year = "2018",
month = dec,
doi = "10.1016/j.sleep.2018.08.022",
language = "English",
volume = "52",
pages = "128--133",
journal = "SLEEP MED",
issn = "1389-9457",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Differences in diffusion tensor imaging changes between narcolepsy with and without cataplexy

AU - Tezer, F Irsel

AU - Erdal, Abidin

AU - Gumusyayla, Sadiye

AU - Has, Arzu Ceylan

AU - Gocmen, Rahsan

AU - Oguz, Kader K

N1 - Copyright © 2018 Elsevier B.V. All rights reserved.

PY - 2018/12

Y1 - 2018/12

N2 - OBJECTIVE: The distinctive clinical finding of Type 1 narcolepsy compared to Type 2 is the presence of cataplexy. Several neuroimaging studies have also reported abnormalities in narcolepsy patients with or without cataplexy. However, there are conflicting results to differentiate them. In this study, we aimed to clarify the white matter changes in narcolepsy patients both with and without cataplexy and compared them with healthy adults to evaluate microstructural differences in the brain.METHODS: Eleven narcolepsy patients with cataplexy (NC), 12 narcolepsy patients without cataplexy (NOC) and healthy age- and gender-matched controls (N = 16) were studied. Whole-brain diffusion tensor imaging (DTI) was obtained and tract-based spatial statistics were used to localize white matter abnormalities.RESULTS: Compared with the healthy controls, both NC and NOC patients exhibited significant fractional anisotropy (FA) decreases in the bilateral cerebellar hemispheres, bilateral thalami, the corpus callosum and left anterior-medial temporal white matter. Compared with the controls, the NC patients' FA values were also decreased in the midbrain. No significant correlations were found between FA values and clinical-polysomnographic variables.CONCLUSION: This DTI study has demonstrated white matter abnormalities in the midbrain-brainstem regions as a distinctive finding of narcolepsy patients with cataplexy. Involvement of bilateral temporal lobes with greater changes on the left lobe is also a supporting finding of patients with cataplexy. DTI changes in the midbrain-brainstem and bilateral temporal lobes can be signs of different pathological mechanisms in these patients.

AB - OBJECTIVE: The distinctive clinical finding of Type 1 narcolepsy compared to Type 2 is the presence of cataplexy. Several neuroimaging studies have also reported abnormalities in narcolepsy patients with or without cataplexy. However, there are conflicting results to differentiate them. In this study, we aimed to clarify the white matter changes in narcolepsy patients both with and without cataplexy and compared them with healthy adults to evaluate microstructural differences in the brain.METHODS: Eleven narcolepsy patients with cataplexy (NC), 12 narcolepsy patients without cataplexy (NOC) and healthy age- and gender-matched controls (N = 16) were studied. Whole-brain diffusion tensor imaging (DTI) was obtained and tract-based spatial statistics were used to localize white matter abnormalities.RESULTS: Compared with the healthy controls, both NC and NOC patients exhibited significant fractional anisotropy (FA) decreases in the bilateral cerebellar hemispheres, bilateral thalami, the corpus callosum and left anterior-medial temporal white matter. Compared with the controls, the NC patients' FA values were also decreased in the midbrain. No significant correlations were found between FA values and clinical-polysomnographic variables.CONCLUSION: This DTI study has demonstrated white matter abnormalities in the midbrain-brainstem regions as a distinctive finding of narcolepsy patients with cataplexy. Involvement of bilateral temporal lobes with greater changes on the left lobe is also a supporting finding of patients with cataplexy. DTI changes in the midbrain-brainstem and bilateral temporal lobes can be signs of different pathological mechanisms in these patients.

KW - Journal Article

U2 - 10.1016/j.sleep.2018.08.022

DO - 10.1016/j.sleep.2018.08.022

M3 - SCORING: Journal article

C2 - 30321819

VL - 52

SP - 128

EP - 133

JO - SLEEP MED

JF - SLEEP MED

SN - 1389-9457

ER -