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Differences Between Central and Peripheral Postmortem Tryptase Levels

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Differences Between Central and Peripheral Postmortem Tryptase Levels. / Garland, Jack; Ondruschka, Benjamin; Da Broi, Ugo; Palmiere, Cristian; Glenn, Charley; Morrow, Paul; Kesha, Kilak; Stables, Simon; Tse, Rexson.

In: AM J FOREN MED PATH, Vol. 42, No. 2, 01.06.2021, p. 125-129.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Garland, J, Ondruschka, B, Da Broi, U, Palmiere, C, Glenn, C, Morrow, P, Kesha, K, Stables, S & Tse, R 2021, 'Differences Between Central and Peripheral Postmortem Tryptase Levels', AM J FOREN MED PATH, vol. 42, no. 2, pp. 125-129. https://doi.org/10.1097/PAF.0000000000000623

APA

Garland, J., Ondruschka, B., Da Broi, U., Palmiere, C., Glenn, C., Morrow, P., Kesha, K., Stables, S., & Tse, R. (2021). Differences Between Central and Peripheral Postmortem Tryptase Levels. AM J FOREN MED PATH, 42(2), 125-129. https://doi.org/10.1097/PAF.0000000000000623

Vancouver

Garland J, Ondruschka B, Da Broi U, Palmiere C, Glenn C, Morrow P et al. Differences Between Central and Peripheral Postmortem Tryptase Levels. AM J FOREN MED PATH. 2021 Jun 1;42(2):125-129. https://doi.org/10.1097/PAF.0000000000000623

Bibtex

@article{34c962d0abd54f519bd18d6188a2d4e0,
title = "Differences Between Central and Peripheral Postmortem Tryptase Levels",
abstract = "ABSTRACT: Postmortem tryptase is a commonly used biochemical test to aid in the diagnosis of fatal anaphylaxis, which is currently recommended to be sampled from peripheral (femoral) veins because of a research showing comparatively elevated levels from central blood sources. Previous studies have used nonstandardized or nondocumented sampling methods; however, more recent research demonstrates that tryptase levels may vary depending on the sampling method. This study used the recommended sampling method of aspirating the femoral vein after clamping and compared in a pairwise comparison with aspiration of central venous and arterial blood sources (inferior vena cava and aorta) in 2 groups of 25 nonanaphylactic deaths. We found no statistically significant differences in postmortem tryptase between central and femoral vein blood; however, sporadic outliers in central blood (particularly aortic blood reaching levels above documented cutoffs for fatal anaphylaxis) were observed. Our findings provide evidence for the existing recommendations that femoral vein blood remains the preferred sample for postmortem tryptase over central blood.",
author = "Jack Garland and Benjamin Ondruschka and {Da Broi}, Ugo and Cristian Palmiere and Charley Glenn and Paul Morrow and Kilak Kesha and Simon Stables and Rexson Tse",
year = "2021",
month = jun,
day = "1",
doi = "10.1097/PAF.0000000000000623",
language = "English",
volume = "42",
pages = "125--129",
journal = "AM J FOREN MED PATH",
issn = "0195-7910",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

RIS

TY - JOUR

T1 - Differences Between Central and Peripheral Postmortem Tryptase Levels

AU - Garland, Jack

AU - Ondruschka, Benjamin

AU - Da Broi, Ugo

AU - Palmiere, Cristian

AU - Glenn, Charley

AU - Morrow, Paul

AU - Kesha, Kilak

AU - Stables, Simon

AU - Tse, Rexson

PY - 2021/6/1

Y1 - 2021/6/1

N2 - ABSTRACT: Postmortem tryptase is a commonly used biochemical test to aid in the diagnosis of fatal anaphylaxis, which is currently recommended to be sampled from peripheral (femoral) veins because of a research showing comparatively elevated levels from central blood sources. Previous studies have used nonstandardized or nondocumented sampling methods; however, more recent research demonstrates that tryptase levels may vary depending on the sampling method. This study used the recommended sampling method of aspirating the femoral vein after clamping and compared in a pairwise comparison with aspiration of central venous and arterial blood sources (inferior vena cava and aorta) in 2 groups of 25 nonanaphylactic deaths. We found no statistically significant differences in postmortem tryptase between central and femoral vein blood; however, sporadic outliers in central blood (particularly aortic blood reaching levels above documented cutoffs for fatal anaphylaxis) were observed. Our findings provide evidence for the existing recommendations that femoral vein blood remains the preferred sample for postmortem tryptase over central blood.

AB - ABSTRACT: Postmortem tryptase is a commonly used biochemical test to aid in the diagnosis of fatal anaphylaxis, which is currently recommended to be sampled from peripheral (femoral) veins because of a research showing comparatively elevated levels from central blood sources. Previous studies have used nonstandardized or nondocumented sampling methods; however, more recent research demonstrates that tryptase levels may vary depending on the sampling method. This study used the recommended sampling method of aspirating the femoral vein after clamping and compared in a pairwise comparison with aspiration of central venous and arterial blood sources (inferior vena cava and aorta) in 2 groups of 25 nonanaphylactic deaths. We found no statistically significant differences in postmortem tryptase between central and femoral vein blood; however, sporadic outliers in central blood (particularly aortic blood reaching levels above documented cutoffs for fatal anaphylaxis) were observed. Our findings provide evidence for the existing recommendations that femoral vein blood remains the preferred sample for postmortem tryptase over central blood.

U2 - 10.1097/PAF.0000000000000623

DO - 10.1097/PAF.0000000000000623

M3 - SCORING: Journal article

C2 - 33031126

VL - 42

SP - 125

EP - 129

JO - AM J FOREN MED PATH

JF - AM J FOREN MED PATH

SN - 0195-7910

IS - 2

ER -