Die wichtigsten Studienergebnisse zur nichtchirurgischen Primärtherapie lokal fortgeschrittener Kopf‑Hals‑Tumoren
Standard
Die wichtigsten Studienergebnisse zur nichtchirurgischen Primärtherapie lokal fortgeschrittener Kopf‑Hals‑Tumoren : Highlights des ASCO-Kongresses 2015. / Gliese, A; Busch, C-J; Knecht, R.
In: HNO, Vol. 63, No. 9, 09.2015, p. 606-11.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Die wichtigsten Studienergebnisse zur nichtchirurgischen Primärtherapie lokal fortgeschrittener Kopf‑Hals‑Tumoren
T2 - Highlights des ASCO-Kongresses 2015
AU - Gliese, A
AU - Busch, C-J
AU - Knecht, R
PY - 2015/9
Y1 - 2015/9
N2 - At the Annual Meeting of the American Society of Clinical Oncology (ASCO) 2015, results of current trials dealing with nonsurgical primary treatment of locally advanced head and neck cancer were presented. Regarding concomitant chemoradiotherapy (CRT), studies focused on the dosage and sequence of cisplatin administration are currently particularly featured. Amongst these, a study on dosage reduction in human papilloma virus (HPV)-positive patients was presented. Other investigations addressed substances as alternatives for cisplatin, particularly carboplatin and targeted therapeutic agents. The comparison of concomitant and sequential CRT (induction chemotherapy (ICT) prior to CRT) is still one of the main topics. In addition, studies modifying the ICT regimen or combining subsequent radiotherapy (RT) with the epidermal growth factor receptor (EGFR) antibody cetuximab were presented. A selection of the most important trials are summarized in this article.
AB - At the Annual Meeting of the American Society of Clinical Oncology (ASCO) 2015, results of current trials dealing with nonsurgical primary treatment of locally advanced head and neck cancer were presented. Regarding concomitant chemoradiotherapy (CRT), studies focused on the dosage and sequence of cisplatin administration are currently particularly featured. Amongst these, a study on dosage reduction in human papilloma virus (HPV)-positive patients was presented. Other investigations addressed substances as alternatives for cisplatin, particularly carboplatin and targeted therapeutic agents. The comparison of concomitant and sequential CRT (induction chemotherapy (ICT) prior to CRT) is still one of the main topics. In addition, studies modifying the ICT regimen or combining subsequent radiotherapy (RT) with the epidermal growth factor receptor (EGFR) antibody cetuximab were presented. A selection of the most important trials are summarized in this article.
KW - Antibodies, Monoclonal
KW - Carboplatin
KW - Chemoradiotherapy
KW - Cisplatin
KW - Drug Administration Schedule
KW - Head and Neck Neoplasms
KW - Humans
KW - Molecular Targeted Therapy
KW - Neoplasm Invasiveness
KW - Otorhinolaryngologic Surgical Procedures
KW - Treatment Outcome
KW - Congresses
KW - English Abstract
U2 - 10.1007/s00106-015-0053-2
DO - 10.1007/s00106-015-0053-2
M3 - SCORING: Zeitschriftenaufsatz
C2 - 26303521
VL - 63
SP - 606
EP - 611
JO - HNO
JF - HNO
SN - 0017-6192
IS - 9
ER -