Die bikuspide Aortenklappe
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Die bikuspide Aortenklappe. / Hillebrand, M.; Bernhardt, A.; Aydin, A.; Blankenberg, S.; Willems, S.; Von Kodolitsch, Y.; Lorenzen, Victoria.
In: Medizinische Welt, Vol. 64, No. 2, 2013, p. 106-109.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Die bikuspide Aortenklappe
AU - Hillebrand, M.
AU - Bernhardt, A.
AU - Aydin, A.
AU - Blankenberg, S.
AU - Willems, S.
AU - Von Kodolitsch, Y.
AU - Lorenzen, Victoria
PY - 2013
Y1 - 2013
N2 - Bicuspid aortic valve disease (BAV) is one of the most frequent congenital heart defects, and can be associated with other cardiovascular lesions. The most common complication is an associated valvular dysfunction consisting of aortic stenosis, aortic regurgitation, or infective endocarditis. Furthermore, it can lead to dilation of the ascending aorta with the potential complication of aortic dissection. Histopathological alterations such as cystic media necrosis with loss of smooth muscle cells indicate that BAV may be a systemic disease. Cardiologic imaging modalities such as echocardiography and MRI or CT of the aorta are necessary for timely detection of cardiovascular complications, and for timing of prophylactic aortic surgery. Further clinical studies are substantial for better understanding of the disease and to define optimal timing for interventions. This article focuses on current clinical guidelines, summarizes the pathophysiological and genetic basis of BAV, and outlines therapeutic strategies.
AB - Bicuspid aortic valve disease (BAV) is one of the most frequent congenital heart defects, and can be associated with other cardiovascular lesions. The most common complication is an associated valvular dysfunction consisting of aortic stenosis, aortic regurgitation, or infective endocarditis. Furthermore, it can lead to dilation of the ascending aorta with the potential complication of aortic dissection. Histopathological alterations such as cystic media necrosis with loss of smooth muscle cells indicate that BAV may be a systemic disease. Cardiologic imaging modalities such as echocardiography and MRI or CT of the aorta are necessary for timely detection of cardiovascular complications, and for timing of prophylactic aortic surgery. Further clinical studies are substantial for better understanding of the disease and to define optimal timing for interventions. This article focuses on current clinical guidelines, summarizes the pathophysiological and genetic basis of BAV, and outlines therapeutic strategies.
KW - Aortic dilation
KW - Aortic regurgitation
KW - Aortic valve stenosis
KW - Bicuspid aortic valve
UR - http://www.scopus.com/inward/record.url?scp=84877120792&partnerID=8YFLogxK
M3 - SCORING: Zeitschriftenaufsatz
AN - SCOPUS:84877120792
VL - 64
SP - 106
EP - 109
JO - MED WELT
JF - MED WELT
SN - 0025-8512
IS - 2
ER -
