Diaphanous-related formin 1 as a target for tumor therapy

Yuan-Na Lin; Sabine Windhorst

doi:10.1042/BST20160120

Diaphanous-related formin 1 as a target for tumor therapy

Standard

In: BIOCHEM SOC T, Vol. 44, No. 5, 15.10.2016, p. 1289-1293.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Lin, Y-N & Windhorst, S 2016, 'Diaphanous-related formin 1 as a target for tumor therapy', BIOCHEM SOC T, vol. 44, no. 5, pp. 1289-1293. https://doi.org/10.1042/BST20160120

APA

Lin, Y-N., & Windhorst, S. (2016). Diaphanous-related formin 1 as a target for tumor therapy. BIOCHEM SOC T, 44(5), 1289-1293. https://doi.org/10.1042/BST20160120

Vancouver

Lin Y-N, Windhorst S. Diaphanous-related formin 1 as a target for tumor therapy. BIOCHEM SOC T. 2016 Oct 15;44(5):1289-1293. https://doi.org/10.1042/BST20160120

Bibtex

@article{3429b94076e44996b39190ebe2a7e8a5,

title = "Diaphanous-related formin 1 as a target for tumor therapy",

abstract = "Formins nucleate actin and stabilize microtubules (MTs). Expression of the formin Diaphanous homolog 1 (DIAPH1) is increased in malignant colon carcinoma cells, while expression of DIAPH3 is up-regulated in breast and prostate carcinoma cells. Both DIAPH1 isoforms are required to stabilize interphase MTs of cancer cells, and it has been shown that loss of this function decreases the metastatic potential of these cells. Moreover, depletion of DIAPH3 increases the sensitivity of breast and prostate carcinoma cells to taxanes. In contrast with DIAPH1 + 3, DIAPH2 regulates metaphase MTs of tumor cells by stabilizing binding of kinetochore MTs to chromosomes. Depletion of DIAPH2 impairs chromosome alignment, thus proper chromosome segregation during mitosis. In summary, expression of DIAPH formins in tumor cells is essential for stabilizing interphase or metaphase MTs, respectively. Thus, it would be very interesting to analyze if tumor cells exhibiting low DIAPH expression are more sensitive to taxanes than those with high DIAPH expression.",

keywords = "Review, Journal Article",

author = "Yuan-Na Lin and Sabine Windhorst",

note = "{\textcopyright} 2016 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society.",

year = "2016",

month = oct,

day = "15",

doi = "10.1042/BST20160120",

language = "English",

volume = "44",

pages = "1289--1293",

journal = "BIOCHEM SOC T",

issn = "0300-5127",

publisher = "PORTLAND PRESS LTD",

number = "5",

}

RIS

TY - JOUR

T1 - Diaphanous-related formin 1 as a target for tumor therapy

AU - Lin, Yuan-Na

AU - Windhorst, Sabine

PY - 2016/10/15

Y1 - 2016/10/15

N2 - Formins nucleate actin and stabilize microtubules (MTs). Expression of the formin Diaphanous homolog 1 (DIAPH1) is increased in malignant colon carcinoma cells, while expression of DIAPH3 is up-regulated in breast and prostate carcinoma cells. Both DIAPH1 isoforms are required to stabilize interphase MTs of cancer cells, and it has been shown that loss of this function decreases the metastatic potential of these cells. Moreover, depletion of DIAPH3 increases the sensitivity of breast and prostate carcinoma cells to taxanes. In contrast with DIAPH1 + 3, DIAPH2 regulates metaphase MTs of tumor cells by stabilizing binding of kinetochore MTs to chromosomes. Depletion of DIAPH2 impairs chromosome alignment, thus proper chromosome segregation during mitosis. In summary, expression of DIAPH formins in tumor cells is essential for stabilizing interphase or metaphase MTs, respectively. Thus, it would be very interesting to analyze if tumor cells exhibiting low DIAPH expression are more sensitive to taxanes than those with high DIAPH expression.

AB - Formins nucleate actin and stabilize microtubules (MTs). Expression of the formin Diaphanous homolog 1 (DIAPH1) is increased in malignant colon carcinoma cells, while expression of DIAPH3 is up-regulated in breast and prostate carcinoma cells. Both DIAPH1 isoforms are required to stabilize interphase MTs of cancer cells, and it has been shown that loss of this function decreases the metastatic potential of these cells. Moreover, depletion of DIAPH3 increases the sensitivity of breast and prostate carcinoma cells to taxanes. In contrast with DIAPH1 + 3, DIAPH2 regulates metaphase MTs of tumor cells by stabilizing binding of kinetochore MTs to chromosomes. Depletion of DIAPH2 impairs chromosome alignment, thus proper chromosome segregation during mitosis. In summary, expression of DIAPH formins in tumor cells is essential for stabilizing interphase or metaphase MTs, respectively. Thus, it would be very interesting to analyze if tumor cells exhibiting low DIAPH expression are more sensitive to taxanes than those with high DIAPH expression.

KW - Review

KW - Journal Article

U2 - 10.1042/BST20160120

DO - 10.1042/BST20160120

M3 - SCORING: Journal article

C2 - 27911711

VL - 44

SP - 1289

EP - 1293

JO - BIOCHEM SOC T

JF - BIOCHEM SOC T

SN - 0300-5127

IS - 5

ER -