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Diagnostic and prognostic values of the V-index, a novel ECG marker quantifying spatial heterogeneity of ventricular repolarization, in patients with symptoms suggestive of non-ST-elevation myocardial infarction

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Diagnostic and prognostic values of the V-index, a novel ECG marker quantifying spatial heterogeneity of ventricular repolarization, in patients with symptoms suggestive of non-ST-elevation myocardial infarction. / Abächerli, Roger; Twerenbold, Raphael; Boeddinghaus, Jasper; Nestelberger, Thomas; Mächler, Patrick; Sassi, Roberto; Rivolta, Massimo W.; Roonizi, Ebadollah Kheirati; Mainardi, Luca T.; Kozhuharov, Nikola; Rubini Giménez, Maria; Wildi, Karin; Grimm, Karin; Sabti, Zaid; Hillinger, Petra; Puelacher, Christian; Strebel, Ivo; Cupa, Janosch; Badertscher, Patrick; Roux, Isabelle; Schmid, Ramun; Leber, Remo; Osswald, Stefan; Mueller, Christian; Reichlin, Tobias.

In: INT J CARDIOL, Vol. 236, 01.06.2017, p. 23-29.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Abächerli, R, Twerenbold, R, Boeddinghaus, J, Nestelberger, T, Mächler, P, Sassi, R, Rivolta, MW, Roonizi, EK, Mainardi, LT, Kozhuharov, N, Rubini Giménez, M, Wildi, K, Grimm, K, Sabti, Z, Hillinger, P, Puelacher, C, Strebel, I, Cupa, J, Badertscher, P, Roux, I, Schmid, R, Leber, R, Osswald, S, Mueller, C & Reichlin, T 2017, 'Diagnostic and prognostic values of the V-index, a novel ECG marker quantifying spatial heterogeneity of ventricular repolarization, in patients with symptoms suggestive of non-ST-elevation myocardial infarction', INT J CARDIOL, vol. 236, pp. 23-29. https://doi.org/10.1016/j.ijcard.2017.01.151

APA

Abächerli, R., Twerenbold, R., Boeddinghaus, J., Nestelberger, T., Mächler, P., Sassi, R., Rivolta, M. W., Roonizi, E. K., Mainardi, L. T., Kozhuharov, N., Rubini Giménez, M., Wildi, K., Grimm, K., Sabti, Z., Hillinger, P., Puelacher, C., Strebel, I., Cupa, J., Badertscher, P., ... Reichlin, T. (2017). Diagnostic and prognostic values of the V-index, a novel ECG marker quantifying spatial heterogeneity of ventricular repolarization, in patients with symptoms suggestive of non-ST-elevation myocardial infarction. INT J CARDIOL, 236, 23-29. https://doi.org/10.1016/j.ijcard.2017.01.151

Vancouver

Abächerli R, Twerenbold R, Boeddinghaus J, Nestelberger T, Mächler P, Sassi R et al. Diagnostic and prognostic values of the V-index, a novel ECG marker quantifying spatial heterogeneity of ventricular repolarization, in patients with symptoms suggestive of non-ST-elevation myocardial infarction. INT J CARDIOL. 2017 Jun 1;236:23-29. https://doi.org/10.1016/j.ijcard.2017.01.151

Bibtex

@article{3853280e360d476eb92de44f5bd48460,
title = "Diagnostic and prognostic values of the V-index, a novel ECG marker quantifying spatial heterogeneity of ventricular repolarization, in patients with symptoms suggestive of non-ST-elevation myocardial infarction",
abstract = "Background The V-index is an ECG marker quantifying spatial heterogeneity of ventricular repolarization. We prospectively assessed the diagnostic and prognostic values of the V-index in patients with suspected non-ST-elevation myocardial infarction (NSTEMI). Methods We prospectively enrolled 497 patients presenting with suspected NSTEMI to the emergency department (ED). Digital 12-lead ECGs of five-minute duration were recorded at presentation. The V-index was automatically calculated in a blinded fashion. Patients with a QRS duration > 120 ms were ruled out from analysis. The final diagnosis was adjudicated by two independent cardiologists. The prognostic endpoint was all-cause mortality during 24 months of follow-up. Results NSTEMI was the final diagnosis in 14% of patients. V-index levels were higher in patients with AMI compared to other causes of chest pain (median 23 ms vs. 18 ms, p < 0.001). The use of the V-index in addition to conventional ECG-criteria improved the diagnostic accuracy for the diagnosis of NSTEMI as quantified by area under the ROC curve from 0.66 to 0.73 (p = 0.001) and the sensitivity of the ECG for AMI from 41% to 86% (p < 0.001). Cumulative 24-month mortality rates were 99.4%, 98.4% and 88.3% according to tertiles of the V-index (p < 0.001). After adjustment for age and important ECG and clinical parameters, the V-index remained an independent predictor of death. Conclusions The V-index, an ECG marker quantifying spatial heterogeneity of ventricular repolarization, significantly improves the accuracy and sensitivity of the ECG for the diagnosis of NSTEMI and independently predicts mortality during follow-up.",
author = "Roger Ab{\"a}cherli and Raphael Twerenbold and Jasper Boeddinghaus and Thomas Nestelberger and Patrick M{\"a}chler and Roberto Sassi and Rivolta, {Massimo W.} and Roonizi, {Ebadollah Kheirati} and Mainardi, {Luca T.} and Nikola Kozhuharov and {Rubini Gim{\'e}nez}, Maria and Karin Wildi and Karin Grimm and Zaid Sabti and Petra Hillinger and Christian Puelacher and Ivo Strebel and Janosch Cupa and Patrick Badertscher and Isabelle Roux and Ramun Schmid and Remo Leber and Stefan Osswald and Christian Mueller and Tobias Reichlin",
note = "Publisher Copyright: {\textcopyright} 2017 Elsevier B.V.",
year = "2017",
month = jun,
day = "1",
doi = "10.1016/j.ijcard.2017.01.151",
language = "English",
volume = "236",
pages = "23--29",
journal = "INT J CARDIOL",
issn = "0167-5273",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Diagnostic and prognostic values of the V-index, a novel ECG marker quantifying spatial heterogeneity of ventricular repolarization, in patients with symptoms suggestive of non-ST-elevation myocardial infarction

AU - Abächerli, Roger

AU - Twerenbold, Raphael

AU - Boeddinghaus, Jasper

AU - Nestelberger, Thomas

AU - Mächler, Patrick

AU - Sassi, Roberto

AU - Rivolta, Massimo W.

AU - Roonizi, Ebadollah Kheirati

AU - Mainardi, Luca T.

AU - Kozhuharov, Nikola

AU - Rubini Giménez, Maria

AU - Wildi, Karin

AU - Grimm, Karin

AU - Sabti, Zaid

AU - Hillinger, Petra

AU - Puelacher, Christian

AU - Strebel, Ivo

AU - Cupa, Janosch

AU - Badertscher, Patrick

AU - Roux, Isabelle

AU - Schmid, Ramun

AU - Leber, Remo

AU - Osswald, Stefan

AU - Mueller, Christian

AU - Reichlin, Tobias

N1 - Publisher Copyright: © 2017 Elsevier B.V.

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Background The V-index is an ECG marker quantifying spatial heterogeneity of ventricular repolarization. We prospectively assessed the diagnostic and prognostic values of the V-index in patients with suspected non-ST-elevation myocardial infarction (NSTEMI). Methods We prospectively enrolled 497 patients presenting with suspected NSTEMI to the emergency department (ED). Digital 12-lead ECGs of five-minute duration were recorded at presentation. The V-index was automatically calculated in a blinded fashion. Patients with a QRS duration > 120 ms were ruled out from analysis. The final diagnosis was adjudicated by two independent cardiologists. The prognostic endpoint was all-cause mortality during 24 months of follow-up. Results NSTEMI was the final diagnosis in 14% of patients. V-index levels were higher in patients with AMI compared to other causes of chest pain (median 23 ms vs. 18 ms, p < 0.001). The use of the V-index in addition to conventional ECG-criteria improved the diagnostic accuracy for the diagnosis of NSTEMI as quantified by area under the ROC curve from 0.66 to 0.73 (p = 0.001) and the sensitivity of the ECG for AMI from 41% to 86% (p < 0.001). Cumulative 24-month mortality rates were 99.4%, 98.4% and 88.3% according to tertiles of the V-index (p < 0.001). After adjustment for age and important ECG and clinical parameters, the V-index remained an independent predictor of death. Conclusions The V-index, an ECG marker quantifying spatial heterogeneity of ventricular repolarization, significantly improves the accuracy and sensitivity of the ECG for the diagnosis of NSTEMI and independently predicts mortality during follow-up.

AB - Background The V-index is an ECG marker quantifying spatial heterogeneity of ventricular repolarization. We prospectively assessed the diagnostic and prognostic values of the V-index in patients with suspected non-ST-elevation myocardial infarction (NSTEMI). Methods We prospectively enrolled 497 patients presenting with suspected NSTEMI to the emergency department (ED). Digital 12-lead ECGs of five-minute duration were recorded at presentation. The V-index was automatically calculated in a blinded fashion. Patients with a QRS duration > 120 ms were ruled out from analysis. The final diagnosis was adjudicated by two independent cardiologists. The prognostic endpoint was all-cause mortality during 24 months of follow-up. Results NSTEMI was the final diagnosis in 14% of patients. V-index levels were higher in patients with AMI compared to other causes of chest pain (median 23 ms vs. 18 ms, p < 0.001). The use of the V-index in addition to conventional ECG-criteria improved the diagnostic accuracy for the diagnosis of NSTEMI as quantified by area under the ROC curve from 0.66 to 0.73 (p = 0.001) and the sensitivity of the ECG for AMI from 41% to 86% (p < 0.001). Cumulative 24-month mortality rates were 99.4%, 98.4% and 88.3% according to tertiles of the V-index (p < 0.001). After adjustment for age and important ECG and clinical parameters, the V-index remained an independent predictor of death. Conclusions The V-index, an ECG marker quantifying spatial heterogeneity of ventricular repolarization, significantly improves the accuracy and sensitivity of the ECG for the diagnosis of NSTEMI and independently predicts mortality during follow-up.

UR - http://www.scopus.com/inward/record.url?scp=85013487397&partnerID=8YFLogxK

U2 - 10.1016/j.ijcard.2017.01.151

DO - 10.1016/j.ijcard.2017.01.151

M3 - SCORING: Journal article

C2 - 28236543

AN - SCOPUS:85013487397

VL - 236

SP - 23

EP - 29

JO - INT J CARDIOL

JF - INT J CARDIOL

SN - 0167-5273

ER -