Diagnosis of Toxoplasma gondii infection after allogeneic stem cell transplant can be difficult and requires intensive scrutiny.
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Diagnosis of Toxoplasma gondii infection after allogeneic stem cell transplant can be difficult and requires intensive scrutiny. / Cavattoni, Irene; Ayuketang Ayuk, Francis; Zander, Axel R.; Zabelina, Tatjana; Bacher, Adelbert; Cayiroglu, Erdogan; Knospe, Volker; Illies, Till; Aepfelbacher, Martin; Richard, Gisbert; Kröger, Nicolaus; Bacher, Ulrike.
In: LEUKEMIA LYMPHOMA, Vol. 51, No. 8, 8, 2010, p. 1530-1535.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Diagnosis of Toxoplasma gondii infection after allogeneic stem cell transplant can be difficult and requires intensive scrutiny.
AU - Cavattoni, Irene
AU - Ayuketang Ayuk, Francis
AU - Zander, Axel R.
AU - Zabelina, Tatjana
AU - Bacher, Adelbert
AU - Cayiroglu, Erdogan
AU - Knospe, Volker
AU - Illies, Till
AU - Aepfelbacher, Martin
AU - Richard, Gisbert
AU - Kröger, Nicolaus
AU - Bacher, Ulrike
PY - 2010
Y1 - 2010
N2 - Infectious complications remain a major problem after allogeneic hematopoietic stem cell transplant (HSCT). Specifically Toxoplasma gondii infection is a life-threatening condition in immunocompromised patients. In order to highlight the difficulties in obtaining an early and definitive diagnosis, we report three cases of toxoplasmosis after HSCT for hematologic malignancies: two cases of T. gondii retinochoroiditis, and one case of encephalitis. All patients had unrelated donors and received antithymocyte globulin; none had received trimethoprim/sulfamethoxazole prophylaxis. Toxoplasmosis occurred early post-transplant and diagnosis was obtained by real-time PCR. In one case, the correct diagnosis could only be established by PCR analysis of a retinal biopsy specimen. Rapid diagnosis--by invasive approaches--and an immediate onset of antiparasite treatment are crucial to avoid disseminated and often lethal Toxoplasma infections in the post-transplant period. Post-transplant prevention strategies and treatment to control advanced infection in this setting are discussed.
AB - Infectious complications remain a major problem after allogeneic hematopoietic stem cell transplant (HSCT). Specifically Toxoplasma gondii infection is a life-threatening condition in immunocompromised patients. In order to highlight the difficulties in obtaining an early and definitive diagnosis, we report three cases of toxoplasmosis after HSCT for hematologic malignancies: two cases of T. gondii retinochoroiditis, and one case of encephalitis. All patients had unrelated donors and received antithymocyte globulin; none had received trimethoprim/sulfamethoxazole prophylaxis. Toxoplasmosis occurred early post-transplant and diagnosis was obtained by real-time PCR. In one case, the correct diagnosis could only be established by PCR analysis of a retinal biopsy specimen. Rapid diagnosis--by invasive approaches--and an immediate onset of antiparasite treatment are crucial to avoid disseminated and often lethal Toxoplasma infections in the post-transplant period. Post-transplant prevention strategies and treatment to control advanced infection in this setting are discussed.
M3 - SCORING: Zeitschriftenaufsatz
VL - 51
SP - 1530
EP - 1535
JO - LEUKEMIA LYMPHOMA
JF - LEUKEMIA LYMPHOMA
SN - 1042-8194
IS - 8
M1 - 8
ER -
