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Diabetes mellitus lowers the chance of short-term urinary continence recovery in prostate cancer patients undergoing radical prostatectomy

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Diabetes mellitus lowers the chance of short-term urinary continence recovery in prostate cancer patients undergoing radical prostatectomy. / Philippi, Alexander; Mandel, Philipp; Hohenhorst, Jan L; Wenzel, Mike; Humke, Clara; Wittler, Clarissa; Köllermann, Jens; Steuber, Thomas; Graefen, Markus; Tilki, Derya; Karakiewicz, Pierre I; Preisser, Felix; Becker, Andreas; Kluth, Luis A; Chun, Felix K H; Hoeh, Benedikt.

In: CENT EUR J UROL, Vol. 75, No. 2, 2022, p. 162-168.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Philippi, A, Mandel, P, Hohenhorst, JL, Wenzel, M, Humke, C, Wittler, C, Köllermann, J, Steuber, T, Graefen, M, Tilki, D, Karakiewicz, PI, Preisser, F, Becker, A, Kluth, LA, Chun, FKH & Hoeh, B 2022, 'Diabetes mellitus lowers the chance of short-term urinary continence recovery in prostate cancer patients undergoing radical prostatectomy', CENT EUR J UROL, vol. 75, no. 2, pp. 162-168. https://doi.org/10.5173/ceju.2022.0279.R1

APA

Philippi, A., Mandel, P., Hohenhorst, J. L., Wenzel, M., Humke, C., Wittler, C., Köllermann, J., Steuber, T., Graefen, M., Tilki, D., Karakiewicz, P. I., Preisser, F., Becker, A., Kluth, L. A., Chun, F. K. H., & Hoeh, B. (2022). Diabetes mellitus lowers the chance of short-term urinary continence recovery in prostate cancer patients undergoing radical prostatectomy. CENT EUR J UROL, 75(2), 162-168. https://doi.org/10.5173/ceju.2022.0279.R1

Vancouver

Philippi A, Mandel P, Hohenhorst JL, Wenzel M, Humke C, Wittler C et al. Diabetes mellitus lowers the chance of short-term urinary continence recovery in prostate cancer patients undergoing radical prostatectomy. CENT EUR J UROL. 2022;75(2):162-168. https://doi.org/10.5173/ceju.2022.0279.R1

Bibtex

@article{c304fd6b7e51404ea99e58d173ce3e01,
title = "Diabetes mellitus lowers the chance of short-term urinary continence recovery in prostate cancer patients undergoing radical prostatectomy",
abstract = "INTRODUCTION: The aim of this article was to test the impact of diabetes mellitus (DM) on short-term urinary continence in patients undergoing radical prostatectomy (RP).MATERIAL AND METHODS: We relied on an institutional tertiary-care database to identify patients who underwent RP between 11/2018 and 02/2021 with data available on short-term urinary continence status (30-90 days post-surgery). Continence was defined as the usage of no or one safety-pad within 24 hours. Univariable and multivariable logistic regression models tested the correlation between DM and short-term continence. Covariates consisted of pathological T-stage, body mass index, prostate volume, surgical approach and nerve-sparing.RESULTS: Of 142 eligible patients, 15 (11%) patients exhibited concomitant DM. Patients diagnosed with DM exhibited lower continence rates at short-term follow-up compared to patients without DM (33 vs 63%, p = 0.03). In univariable and multivariable logistic regression models, DM was strongly associated with reduced chances of short-term urinary continence recovery (multivariable odds ratio [OR]: 0.26, 95%-CI: 0.07-0.86; p = 0.03). Furthermore, pathological T-stage (pT3/pT4) was additionally associated with reduced chance of urinary continence in logistic regression models (multivariable OR: 0.43, 95%-CI: 0.19-0.94; p = 0.04). Other covariables failed to reach statistical significance in multivariable logistic regression analyses predicting urinary continence.CONCLUSIONS: DM was associated with lower chances of short-term urinary continence recovery in a contemporary cohort of patients undergoing radical prostatectomy. Patients with DM should be preoperatively informed and intensified, postoperative pelvic floor training should be considered in this subgroup of RP patients.",
author = "Alexander Philippi and Philipp Mandel and Hohenhorst, {Jan L} and Mike Wenzel and Clara Humke and Clarissa Wittler and Jens K{\"o}llermann and Thomas Steuber and Markus Graefen and Derya Tilki and Karakiewicz, {Pierre I} and Felix Preisser and Andreas Becker and Kluth, {Luis A} and Chun, {Felix K H} and Benedikt Hoeh",
note = "Copyright by Polish Urological Association.",
year = "2022",
doi = "10.5173/ceju.2022.0279.R1",
language = "English",
volume = "75",
pages = "162--168",
journal = "CENT EUR J UROL",
issn = "2080-4806",
publisher = "Panstwowy Zaklad Wydawnictw Lekarskich",
number = "2",

}

RIS

TY - JOUR

T1 - Diabetes mellitus lowers the chance of short-term urinary continence recovery in prostate cancer patients undergoing radical prostatectomy

AU - Philippi, Alexander

AU - Mandel, Philipp

AU - Hohenhorst, Jan L

AU - Wenzel, Mike

AU - Humke, Clara

AU - Wittler, Clarissa

AU - Köllermann, Jens

AU - Steuber, Thomas

AU - Graefen, Markus

AU - Tilki, Derya

AU - Karakiewicz, Pierre I

AU - Preisser, Felix

AU - Becker, Andreas

AU - Kluth, Luis A

AU - Chun, Felix K H

AU - Hoeh, Benedikt

N1 - Copyright by Polish Urological Association.

PY - 2022

Y1 - 2022

N2 - INTRODUCTION: The aim of this article was to test the impact of diabetes mellitus (DM) on short-term urinary continence in patients undergoing radical prostatectomy (RP).MATERIAL AND METHODS: We relied on an institutional tertiary-care database to identify patients who underwent RP between 11/2018 and 02/2021 with data available on short-term urinary continence status (30-90 days post-surgery). Continence was defined as the usage of no or one safety-pad within 24 hours. Univariable and multivariable logistic regression models tested the correlation between DM and short-term continence. Covariates consisted of pathological T-stage, body mass index, prostate volume, surgical approach and nerve-sparing.RESULTS: Of 142 eligible patients, 15 (11%) patients exhibited concomitant DM. Patients diagnosed with DM exhibited lower continence rates at short-term follow-up compared to patients without DM (33 vs 63%, p = 0.03). In univariable and multivariable logistic regression models, DM was strongly associated with reduced chances of short-term urinary continence recovery (multivariable odds ratio [OR]: 0.26, 95%-CI: 0.07-0.86; p = 0.03). Furthermore, pathological T-stage (pT3/pT4) was additionally associated with reduced chance of urinary continence in logistic regression models (multivariable OR: 0.43, 95%-CI: 0.19-0.94; p = 0.04). Other covariables failed to reach statistical significance in multivariable logistic regression analyses predicting urinary continence.CONCLUSIONS: DM was associated with lower chances of short-term urinary continence recovery in a contemporary cohort of patients undergoing radical prostatectomy. Patients with DM should be preoperatively informed and intensified, postoperative pelvic floor training should be considered in this subgroup of RP patients.

AB - INTRODUCTION: The aim of this article was to test the impact of diabetes mellitus (DM) on short-term urinary continence in patients undergoing radical prostatectomy (RP).MATERIAL AND METHODS: We relied on an institutional tertiary-care database to identify patients who underwent RP between 11/2018 and 02/2021 with data available on short-term urinary continence status (30-90 days post-surgery). Continence was defined as the usage of no or one safety-pad within 24 hours. Univariable and multivariable logistic regression models tested the correlation between DM and short-term continence. Covariates consisted of pathological T-stage, body mass index, prostate volume, surgical approach and nerve-sparing.RESULTS: Of 142 eligible patients, 15 (11%) patients exhibited concomitant DM. Patients diagnosed with DM exhibited lower continence rates at short-term follow-up compared to patients without DM (33 vs 63%, p = 0.03). In univariable and multivariable logistic regression models, DM was strongly associated with reduced chances of short-term urinary continence recovery (multivariable odds ratio [OR]: 0.26, 95%-CI: 0.07-0.86; p = 0.03). Furthermore, pathological T-stage (pT3/pT4) was additionally associated with reduced chance of urinary continence in logistic regression models (multivariable OR: 0.43, 95%-CI: 0.19-0.94; p = 0.04). Other covariables failed to reach statistical significance in multivariable logistic regression analyses predicting urinary continence.CONCLUSIONS: DM was associated with lower chances of short-term urinary continence recovery in a contemporary cohort of patients undergoing radical prostatectomy. Patients with DM should be preoperatively informed and intensified, postoperative pelvic floor training should be considered in this subgroup of RP patients.

U2 - 10.5173/ceju.2022.0279.R1

DO - 10.5173/ceju.2022.0279.R1

M3 - SCORING: Journal article

C2 - 35937658

VL - 75

SP - 162

EP - 168

JO - CENT EUR J UROL

JF - CENT EUR J UROL

SN - 2080-4806

IS - 2

ER -