Research ExplorerPublicationsDevelopment of interleukin-17-producing γδ T cells is restri...

Development of interleukin-17-producing γδ T cells is restricted to a functional embryonic wave

Standard

Development of interleukin-17-producing γδ T cells is restricted to a functional embryonic wave. / Haas, Jan D; Ravens, Sarina; Düber, Sandra; Sandrock, Inga; Oberdörfer, Linda; Kashani, Elham; Chennupati, Vijaykumar; Föhse, Lisa; Naumann, Ronald; Weiss, Siegfried; Krueger, Andreas; Förster, Reinhold; Prinz, Immo.

In: IMMUNITY, Vol. 37, No. 1, 27.07.2012, p. 48-59.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Haas, JD, Ravens, S, Düber, S, Sandrock, I, Oberdörfer, L, Kashani, E, Chennupati, V, Föhse, L, Naumann, R, Weiss, S, Krueger, A, Förster, R & Prinz, I 2012, 'Development of interleukin-17-producing γδ T cells is restricted to a functional embryonic wave', IMMUNITY, vol. 37, no. 1, pp. 48-59. https://doi.org/10.1016/j.immuni.2012.06.003

APA

Haas, J. D., Ravens, S., Düber, S., Sandrock, I., Oberdörfer, L., Kashani, E., Chennupati, V., Föhse, L., Naumann, R., Weiss, S., Krueger, A., Förster, R., & Prinz, I. (2012). Development of interleukin-17-producing γδ T cells is restricted to a functional embryonic wave. IMMUNITY, 37(1), 48-59. https://doi.org/10.1016/j.immuni.2012.06.003

Vancouver

Haas JD, Ravens S, Düber S, Sandrock I, Oberdörfer L, Kashani E et al. Development of interleukin-17-producing γδ T cells is restricted to a functional embryonic wave. IMMUNITY. 2012 Jul 27;37(1):48-59. https://doi.org/10.1016/j.immuni.2012.06.003

Bibtex

@article{a3ebbf7798004e8b9159fec5d7832542,
title = "Development of interleukin-17-producing γδ T cells is restricted to a functional embryonic wave",
abstract = "γδ T cells are an important innate source of interleukin-17 (IL-17). In contrast to T helper 17 (Th17) cell differentiation, which occurs in the periphery, IL-17-producing γδ T cells (γδT17 cells) are probably committed during thymic development. To study when γδT17 cells arise during ontogeny, we used TcrdH2BeGFP reporter mice to monitor T cell receptor (TCR) rearrangement and IL-17 production in the embryonic thymus. We observed that several populations such as innate lymphoid cells and early T cell precursors were able to produce IL-17 prior to (and thus independent of) TCR recombination. γδT17 cells were absent after transplantation of IL-17-sufficient bone marrow into mice lacking both Il17a and Il17f. Also, γδT17 cells were not generated after genetic restoration of defective Rag1 function in adult mice. Together, these data suggested that these cells developed exclusively before birth and subsequently persisted in adult mice as self-renewing, long-lived cells.",
keywords = "Animals, Bone Marrow/metabolism, Chimerism, Homeostasis/immunology, Immunity, Innate, Interleukin-17/biosynthesis, Mice, Mice, Inbred C57BL, Mice, Knockout, Receptors, Antigen, T-Cell, alpha-beta/immunology, Receptors, Antigen, T-Cell, gamma-delta/immunology, Receptors, CCR6/metabolism, T-Lymphocyte Subsets/immunology, Thymocytes/cytology, Thymus Gland/embryology, Tumor Necrosis Factor Receptor Superfamily, Member 7/metabolism",
author = "Haas, {Jan D} and Sarina Ravens and Sandra D{\"u}ber and Inga Sandrock and Linda Oberd{\"o}rfer and Elham Kashani and Vijaykumar Chennupati and Lisa F{\"o}hse and Ronald Naumann and Siegfried Weiss and Andreas Krueger and Reinhold F{\"o}rster and Immo Prinz",
note = "Copyright {\textcopyright} 2012 Elsevier Inc. All rights reserved.",
year = "2012",
month = jul,
day = "27",
doi = "10.1016/j.immuni.2012.06.003",
language = "English",
volume = "37",
pages = "48--59",
journal = "IMMUNITY",
issn = "1074-7613",
publisher = "Cell Press",
number = "1",

}

RIS

TY - JOUR

T1 - Development of interleukin-17-producing γδ T cells is restricted to a functional embryonic wave

AU - Haas, Jan D

AU - Ravens, Sarina

AU - Düber, Sandra

AU - Sandrock, Inga

AU - Oberdörfer, Linda

AU - Kashani, Elham

AU - Chennupati, Vijaykumar

AU - Föhse, Lisa

AU - Naumann, Ronald

AU - Weiss, Siegfried

AU - Krueger, Andreas

AU - Förster, Reinhold

AU - Prinz, Immo

N1 - Copyright © 2012 Elsevier Inc. All rights reserved.

PY - 2012/7/27

Y1 - 2012/7/27

N2 - γδ T cells are an important innate source of interleukin-17 (IL-17). In contrast to T helper 17 (Th17) cell differentiation, which occurs in the periphery, IL-17-producing γδ T cells (γδT17 cells) are probably committed during thymic development. To study when γδT17 cells arise during ontogeny, we used TcrdH2BeGFP reporter mice to monitor T cell receptor (TCR) rearrangement and IL-17 production in the embryonic thymus. We observed that several populations such as innate lymphoid cells and early T cell precursors were able to produce IL-17 prior to (and thus independent of) TCR recombination. γδT17 cells were absent after transplantation of IL-17-sufficient bone marrow into mice lacking both Il17a and Il17f. Also, γδT17 cells were not generated after genetic restoration of defective Rag1 function in adult mice. Together, these data suggested that these cells developed exclusively before birth and subsequently persisted in adult mice as self-renewing, long-lived cells.

AB - γδ T cells are an important innate source of interleukin-17 (IL-17). In contrast to T helper 17 (Th17) cell differentiation, which occurs in the periphery, IL-17-producing γδ T cells (γδT17 cells) are probably committed during thymic development. To study when γδT17 cells arise during ontogeny, we used TcrdH2BeGFP reporter mice to monitor T cell receptor (TCR) rearrangement and IL-17 production in the embryonic thymus. We observed that several populations such as innate lymphoid cells and early T cell precursors were able to produce IL-17 prior to (and thus independent of) TCR recombination. γδT17 cells were absent after transplantation of IL-17-sufficient bone marrow into mice lacking both Il17a and Il17f. Also, γδT17 cells were not generated after genetic restoration of defective Rag1 function in adult mice. Together, these data suggested that these cells developed exclusively before birth and subsequently persisted in adult mice as self-renewing, long-lived cells.

KW - Animals

KW - Bone Marrow/metabolism

KW - Chimerism

KW - Homeostasis/immunology

KW - Immunity, Innate

KW - Interleukin-17/biosynthesis

KW - Mice

KW - Mice, Inbred C57BL

KW - Mice, Knockout

KW - Receptors, Antigen, T-Cell, alpha-beta/immunology

KW - Receptors, Antigen, T-Cell, gamma-delta/immunology

KW - Receptors, CCR6/metabolism

KW - T-Lymphocyte Subsets/immunology

KW - Thymocytes/cytology

KW - Thymus Gland/embryology

KW - Tumor Necrosis Factor Receptor Superfamily, Member 7/metabolism

U2 - 10.1016/j.immuni.2012.06.003

DO - 10.1016/j.immuni.2012.06.003

M3 - SCORING: Journal article

C2 - 22770884

VL - 37

SP - 48

EP - 59

JO - IMMUNITY

JF - IMMUNITY

SN - 1074-7613

IS - 1

ER -