Development and internal validation of preoperative transition zone prostate cancer nomogram.
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Development and internal validation of preoperative transition zone prostate cancer nomogram. / Steuber, Thomas; Chun, Felix K-H; Erbersdobler, Andreas; Briganti, Alberto; Haese, Alexander; Graefen, Markus; Schlomm, Thorsten; Valiquette, Luc; Huland, Hartwig; Karakiewicz, Pierre I.
In: UROLOGY, Vol. 68, No. 6, 6, 2006, p. 1295-1300.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Development and internal validation of preoperative transition zone prostate cancer nomogram.
AU - Steuber, Thomas
AU - Chun, Felix K-H
AU - Erbersdobler, Andreas
AU - Briganti, Alberto
AU - Haese, Alexander
AU - Graefen, Markus
AU - Schlomm, Thorsten
AU - Valiquette, Luc
AU - Huland, Hartwig
AU - Karakiewicz, Pierre I
PY - 2006
Y1 - 2006
N2 - OBJECTIVES: Up to 20% of men may harbor a transition zone (TZ) prostate cancer (PCa) at radical prostatectomy (RP). TZ PCa may be associated with more favorable RP pathologic findings than peripheral zone (PZ) PCa. To identify these men, we developed a model capable of predicting the probability of TZ PCa at RP. METHODS: The study cohort consisted of 945 consecutive men treated with RP, with clinical stage, prostate-specific antigen (PSA) level, and detailed biopsy and RP pathology data available. The preoperative variables were used as predictors in the multivariate logistic regression models to predict the rate of TZ PCa at RP. PCa was defined as a TZ tumor when more than 50% of the planimetrically measured tumor volume was situated within the TZ. Regression coefficients were used to develop nomograms, which were subjected to 200 bootstrap resamples to reduce overfit bias. RESULTS: TZ PCa at the final pathologic examination was recorded in 110 patients (11.6%). After 200 bootstraps, the most parsimonious and most accurate nomogram was 77.3% accurate in predicting the probability of TZ PCa. CONCLUSIONS: This nomogram is ideally suited to identify patients with markedly elevated, nearly metastatic serum PSA levels who harbor a TZ tumor that is highly treatable by RP.
AB - OBJECTIVES: Up to 20% of men may harbor a transition zone (TZ) prostate cancer (PCa) at radical prostatectomy (RP). TZ PCa may be associated with more favorable RP pathologic findings than peripheral zone (PZ) PCa. To identify these men, we developed a model capable of predicting the probability of TZ PCa at RP. METHODS: The study cohort consisted of 945 consecutive men treated with RP, with clinical stage, prostate-specific antigen (PSA) level, and detailed biopsy and RP pathology data available. The preoperative variables were used as predictors in the multivariate logistic regression models to predict the rate of TZ PCa at RP. PCa was defined as a TZ tumor when more than 50% of the planimetrically measured tumor volume was situated within the TZ. Regression coefficients were used to develop nomograms, which were subjected to 200 bootstrap resamples to reduce overfit bias. RESULTS: TZ PCa at the final pathologic examination was recorded in 110 patients (11.6%). After 200 bootstraps, the most parsimonious and most accurate nomogram was 77.3% accurate in predicting the probability of TZ PCa. CONCLUSIONS: This nomogram is ideally suited to identify patients with markedly elevated, nearly metastatic serum PSA levels who harbor a TZ tumor that is highly treatable by RP.
M3 - SCORING: Zeitschriftenaufsatz
VL - 68
SP - 1295
EP - 1300
JO - UROLOGY
JF - UROLOGY
SN - 0090-4295
IS - 6
M1 - 6
ER -
