[Determination of DNA damage in vitro].
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[Determination of DNA damage in vitro]. / Dikomey, Ekkehard.
In: NUKLEARMED-NUCL MED, Vol. 49, No. 1, 1, 2010, p. 64-68.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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RIS
TY - JOUR
T1 - [Determination of DNA damage in vitro].
AU - Dikomey, Ekkehard
PY - 2010
Y1 - 2010
N2 - Ionising irradiation acts primarily via induction of DNA damage, among which double-strand breaks are the most important lesions. These lesions may lead to lethal chromosome aberrations, which are the main reason for cell inactivation. Double-strand breaks can be repaired by several different mechanisms. The regulation of these mechanisms appears be fairly different for normal and tumour cells. Among different cell lines capacity of double-strand break repair varies by only few percents and is known to be determined mostly by genetic factors. Knowledge about double-strand break repair mechanisms and their regulation is important for the optimal application of ionising irradiation in medicine.
AB - Ionising irradiation acts primarily via induction of DNA damage, among which double-strand breaks are the most important lesions. These lesions may lead to lethal chromosome aberrations, which are the main reason for cell inactivation. Double-strand breaks can be repaired by several different mechanisms. The regulation of these mechanisms appears be fairly different for normal and tumour cells. Among different cell lines capacity of double-strand break repair varies by only few percents and is known to be determined mostly by genetic factors. Knowledge about double-strand break repair mechanisms and their regulation is important for the optimal application of ionising irradiation in medicine.
M3 - SCORING: Zeitschriftenaufsatz
VL - 49
SP - 64
EP - 68
JO - NUKLEARMED-NUCL MED
JF - NUKLEARMED-NUCL MED
SN - 0029-5566
IS - 1
M1 - 1
ER -
