Determinants of the middle cerebral artery peak systolic velocity in the human fetus.
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Determinants of the middle cerebral artery peak systolic velocity in the human fetus. / Picklesimer, Amy H; Oepkes, Dick; Moise, Kenneth J; Kush, Michelle L; Weiner, Carl P; Harman, Christopher R; Baschat, Ahmet.
In: AM J OBSTET GYNECOL, Vol. 197, No. 5, 5, 2007, p. 1-4.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Determinants of the middle cerebral artery peak systolic velocity in the human fetus.
AU - Picklesimer, Amy H
AU - Oepkes, Dick
AU - Moise, Kenneth J
AU - Kush, Michelle L
AU - Weiner, Carl P
AU - Harman, Christopher R
AU - Baschat, Ahmet
PY - 2007
Y1 - 2007
N2 - OBJECTIVE: The purpose of this study was to identify physiologic determinants of the peak systolic blood flow velocity (PSV) of the middle cerebral artery (MCA) in the human fetus. STUDY DESIGN: MCA PSV was measured with pulsed wave Doppler ultrasound in human fetuses who underwent cordocentesis. Hemoglobin, hematocrit, and blood gas values were analyzed from umbilical venous blood, and the data were normalized for gestational age. Total oxygen content of fetal venous blood was calculated from oxygen saturation, hemoglobin value, and pO2. Correlation and logistic regression analyses were performed to identify primary physiologic determinants of MCA PSV. RESULTS: In 136 fetuses who underwent cordocentesis (predominantly for alloimmune disease), hematocrit, hemoglobin, and blood oxygen content correlated significantly with the MCA PSV (P <.01). Logistic regression modeling demonstrated that fetal hemoglobin content (odds ratio, 7.1; 95% CI, 3.71-13.7) and pCO2, but not pO2 or fetal blood oxygen content, accounted for increases in MCA PSV. CONCLUSION: Under physiologic circumstances, fetal hemoglobin, and not fetal oxygenation, primarily determines the middle cerebral artery peak systolic velocity.
AB - OBJECTIVE: The purpose of this study was to identify physiologic determinants of the peak systolic blood flow velocity (PSV) of the middle cerebral artery (MCA) in the human fetus. STUDY DESIGN: MCA PSV was measured with pulsed wave Doppler ultrasound in human fetuses who underwent cordocentesis. Hemoglobin, hematocrit, and blood gas values were analyzed from umbilical venous blood, and the data were normalized for gestational age. Total oxygen content of fetal venous blood was calculated from oxygen saturation, hemoglobin value, and pO2. Correlation and logistic regression analyses were performed to identify primary physiologic determinants of MCA PSV. RESULTS: In 136 fetuses who underwent cordocentesis (predominantly for alloimmune disease), hematocrit, hemoglobin, and blood oxygen content correlated significantly with the MCA PSV (P <.01). Logistic regression modeling demonstrated that fetal hemoglobin content (odds ratio, 7.1; 95% CI, 3.71-13.7) and pCO2, but not pO2 or fetal blood oxygen content, accounted for increases in MCA PSV. CONCLUSION: Under physiologic circumstances, fetal hemoglobin, and not fetal oxygenation, primarily determines the middle cerebral artery peak systolic velocity.
M3 - SCORING: Zeitschriftenaufsatz
VL - 197
SP - 1
EP - 4
JO - AM J OBSTET GYNECOL
JF - AM J OBSTET GYNECOL
SN - 0002-9378
IS - 5
M1 - 5
ER -
