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Determinants of the acute-phase protein C-reactive protein in myocardial infarction survivors: the role of comorbidities and environmental factors

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Determinants of the acute-phase protein C-reactive protein in myocardial infarction survivors: the role of comorbidities and environmental factors. / Rückerl, Regina; Peters, Annette; Khuseyinova, Natalie; Andreani, Mariarita; Koenig, Wolfgang; Meisinger, Christa; Dimakopoulou, Konstantina; Sunyer, Jordi; Lanki, Timo; Nyberg, Fredrik; Schneider, Alexandra.

In: CLIN CHEM, Vol. 55, No. 2, 02.2009, p. 322-335.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research

Harvard

Rückerl, R, Peters, A, Khuseyinova, N, Andreani, M, Koenig, W, Meisinger, C, Dimakopoulou, K, Sunyer, J, Lanki, T, Nyberg, F & Schneider, A 2009, 'Determinants of the acute-phase protein C-reactive protein in myocardial infarction survivors: the role of comorbidities and environmental factors', CLIN CHEM, vol. 55, no. 2, pp. 322-335. https://doi.org/10.1373/clinchem.2008.112334

APA

Rückerl, R., Peters, A., Khuseyinova, N., Andreani, M., Koenig, W., Meisinger, C., Dimakopoulou, K., Sunyer, J., Lanki, T., Nyberg, F., & Schneider, A. (2009). Determinants of the acute-phase protein C-reactive protein in myocardial infarction survivors: the role of comorbidities and environmental factors. CLIN CHEM, 55(2), 322-335. https://doi.org/10.1373/clinchem.2008.112334

Vancouver

Rückerl R, Peters A, Khuseyinova N, Andreani M, Koenig W, Meisinger C et al. Determinants of the acute-phase protein C-reactive protein in myocardial infarction survivors: the role of comorbidities and environmental factors. CLIN CHEM. 2009 Feb;55(2):322-335. https://doi.org/10.1373/clinchem.2008.112334

Bibtex

@article{74856e7c376645db939a369cfc8d46ef,
title = "Determinants of the acute-phase protein C-reactive protein in myocardial infarction survivors: the role of comorbidities and environmental factors",
abstract = "BACKGROUND: C-reactive protein (CRP), a sensitive marker of the acute-phase response, has been associated with future cardiovascular endpoints independently of other risk factors. A joint analysis of the role of risk factors in predicting mean concentrations and variation of high-sensitivity CRP (hsCRP) in serum has not been carried out previously.METHODS: We used data from 1003 myocardial infarction (MI) survivors who had hsCRP measured monthly up to 8 times and multivariate mixed effects statistical models to study the role of time-variant and -invariant factors on the geometric mean of and the intraindividual variation in hsCRP concentrations.RESULTS: Patients with > or =6.5% glycosylated hemoglobin (HbA1c) had 26.2% higher hsCRP concentrations (95% CI, 7.2%-48.6%) and 20.7% greater variation in hsCRP values (P = 0.0034) than patients with lower baseline Hb A(1c) values (<6.5%). Similar but less pronounced differences were seen in patients with a self-reported diagnosis of type 2 diabetes. hsCRP concentrations showed less variation in patients who reported angina pectoris, congestive heart failure, or emphysema (-11.0%, -24.9%, and -41.6%, respectively, vs patients without these conditions) but greater variation in males and smokers (+24.8% and +27.3%, respectively, vs females and nonsmokers). Exposures in the 24 h before blood sampling, including exposure to environmental tobacco smoke, alcohol consumption, and extreme stress, did not have a major impact.CONCLUSIONS: One or 2 hsCRP measurements may not be sufficient to adequately characterize different patient groups after MI with similar precisions. We found hsCRP concentrations to be especially variable in males, smokers, and patients with increased Hb A(1c) values.",
keywords = "Adult, Aged, Aged, 80 and over, Air Pollution/adverse effects, Body Mass Index, C-Reactive Protein/analysis, Comorbidity, Data Interpretation, Statistical, Female, Glycated Hemoglobin A/analysis, Humans, Longitudinal Studies, Male, Middle Aged, Myocardial Infarction/blood, Prospective Studies, Risk Factors, Sex Factors, Smoking/adverse effects, Socioeconomic Factors, Surveys and Questionnaires",
author = "Regina R{\"u}ckerl and Annette Peters and Natalie Khuseyinova and Mariarita Andreani and Wolfgang Koenig and Christa Meisinger and Konstantina Dimakopoulou and Jordi Sunyer and Timo Lanki and Fredrik Nyberg and Alexandra Schneider",
year = "2009",
month = feb,
doi = "10.1373/clinchem.2008.112334",
language = "English",
volume = "55",
pages = "322--335",
journal = "CLIN CHEM",
issn = "0009-9147",
publisher = "American Association for Clinical Chemistry Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - Determinants of the acute-phase protein C-reactive protein in myocardial infarction survivors: the role of comorbidities and environmental factors

AU - Rückerl, Regina

AU - Peters, Annette

AU - Khuseyinova, Natalie

AU - Andreani, Mariarita

AU - Koenig, Wolfgang

AU - Meisinger, Christa

AU - Dimakopoulou, Konstantina

AU - Sunyer, Jordi

AU - Lanki, Timo

AU - Nyberg, Fredrik

AU - Schneider, Alexandra

PY - 2009/2

Y1 - 2009/2

N2 - BACKGROUND: C-reactive protein (CRP), a sensitive marker of the acute-phase response, has been associated with future cardiovascular endpoints independently of other risk factors. A joint analysis of the role of risk factors in predicting mean concentrations and variation of high-sensitivity CRP (hsCRP) in serum has not been carried out previously.METHODS: We used data from 1003 myocardial infarction (MI) survivors who had hsCRP measured monthly up to 8 times and multivariate mixed effects statistical models to study the role of time-variant and -invariant factors on the geometric mean of and the intraindividual variation in hsCRP concentrations.RESULTS: Patients with > or =6.5% glycosylated hemoglobin (HbA1c) had 26.2% higher hsCRP concentrations (95% CI, 7.2%-48.6%) and 20.7% greater variation in hsCRP values (P = 0.0034) than patients with lower baseline Hb A(1c) values (<6.5%). Similar but less pronounced differences were seen in patients with a self-reported diagnosis of type 2 diabetes. hsCRP concentrations showed less variation in patients who reported angina pectoris, congestive heart failure, or emphysema (-11.0%, -24.9%, and -41.6%, respectively, vs patients without these conditions) but greater variation in males and smokers (+24.8% and +27.3%, respectively, vs females and nonsmokers). Exposures in the 24 h before blood sampling, including exposure to environmental tobacco smoke, alcohol consumption, and extreme stress, did not have a major impact.CONCLUSIONS: One or 2 hsCRP measurements may not be sufficient to adequately characterize different patient groups after MI with similar precisions. We found hsCRP concentrations to be especially variable in males, smokers, and patients with increased Hb A(1c) values.

AB - BACKGROUND: C-reactive protein (CRP), a sensitive marker of the acute-phase response, has been associated with future cardiovascular endpoints independently of other risk factors. A joint analysis of the role of risk factors in predicting mean concentrations and variation of high-sensitivity CRP (hsCRP) in serum has not been carried out previously.METHODS: We used data from 1003 myocardial infarction (MI) survivors who had hsCRP measured monthly up to 8 times and multivariate mixed effects statistical models to study the role of time-variant and -invariant factors on the geometric mean of and the intraindividual variation in hsCRP concentrations.RESULTS: Patients with > or =6.5% glycosylated hemoglobin (HbA1c) had 26.2% higher hsCRP concentrations (95% CI, 7.2%-48.6%) and 20.7% greater variation in hsCRP values (P = 0.0034) than patients with lower baseline Hb A(1c) values (<6.5%). Similar but less pronounced differences were seen in patients with a self-reported diagnosis of type 2 diabetes. hsCRP concentrations showed less variation in patients who reported angina pectoris, congestive heart failure, or emphysema (-11.0%, -24.9%, and -41.6%, respectively, vs patients without these conditions) but greater variation in males and smokers (+24.8% and +27.3%, respectively, vs females and nonsmokers). Exposures in the 24 h before blood sampling, including exposure to environmental tobacco smoke, alcohol consumption, and extreme stress, did not have a major impact.CONCLUSIONS: One or 2 hsCRP measurements may not be sufficient to adequately characterize different patient groups after MI with similar precisions. We found hsCRP concentrations to be especially variable in males, smokers, and patients with increased Hb A(1c) values.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Air Pollution/adverse effects

KW - Body Mass Index

KW - C-Reactive Protein/analysis

KW - Comorbidity

KW - Data Interpretation, Statistical

KW - Female

KW - Glycated Hemoglobin A/analysis

KW - Humans

KW - Longitudinal Studies

KW - Male

KW - Middle Aged

KW - Myocardial Infarction/blood

KW - Prospective Studies

KW - Risk Factors

KW - Sex Factors

KW - Smoking/adverse effects

KW - Socioeconomic Factors

KW - Surveys and Questionnaires

U2 - 10.1373/clinchem.2008.112334

DO - 10.1373/clinchem.2008.112334

M3 - SCORING: Journal article

C2 - 19095729

VL - 55

SP - 322

EP - 335

JO - CLIN CHEM

JF - CLIN CHEM

SN - 0009-9147

IS - 2

ER -