Detection of microscopic diffusion anisotropy in human cortical gray matter in vivo with double diffusion encoding

Marco Lawrenz; Jürgen Finsterbusch

doi:10.1002/mrm.27451

Detection of microscopic diffusion anisotropy in human cortical gray matter in vivo with double diffusion encoding

Standard

Detection of microscopic diffusion anisotropy in human cortical gray matter in vivo with double diffusion encoding. / Lawrenz, Marco; Finsterbusch, Jürgen.

In: MAGN RESON MED, Vol. 81, No. 2, 02.2019, p. 1296-1306.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Lawrenz, M & Finsterbusch, J 2019, 'Detection of microscopic diffusion anisotropy in human cortical gray matter in vivo with double diffusion encoding', MAGN RESON MED, vol. 81, no. 2, pp. 1296-1306. https://doi.org/10.1002/mrm.27451

APA

Lawrenz, M., & Finsterbusch, J. (2019). Detection of microscopic diffusion anisotropy in human cortical gray matter in vivo with double diffusion encoding. MAGN RESON MED, 81(2), 1296-1306. https://doi.org/10.1002/mrm.27451

Vancouver

Lawrenz M, Finsterbusch J. Detection of microscopic diffusion anisotropy in human cortical gray matter in vivo with double diffusion encoding. MAGN RESON MED. 2019 Feb;81(2):1296-1306. https://doi.org/10.1002/mrm.27451

Bibtex

@article{7d88472ae5fc496ab8c8940ff8c343d5,

title = "Detection of microscopic diffusion anisotropy in human cortical gray matter in vivo with double diffusion encoding",

abstract = "PURPOSE: To detect microscopic diffusion anisotropy in human cortical gray matter in vivo with double diffusion encoding experiments.METHODS: Double diffusion encoding experiments were performed on a 3 T whole-body MR system using echo-planar imaging. Angular double diffusion encoding measurements were acquired with 8 × 8 and 12 × 12 planar direction combinations and were analyzed in three regions of interest containing white matter, mostly cortical gray matter, and one having significant contributions from cerebrospinal fluid. Inversion with variable recovery times served to estimate and eliminate white matter partial volume effects. To investigate the influence of magnetic field inhomogeneities, experiments with gradient offsets and cross-term compensated diffusion weightings were performed. The MA index, a rotationally invariant measure of the microscopic diffusion anisotropy, was determined from measurements with 96 direction combinations.RESULTS: The angular signal modulation in the gray matter region of interest has two components, one being consistent, inter alia, with cross terms with field inhomogeneities while the other represents a signal difference between parallel/antiparallel and orthogonal direction combinations, ie, the fingerprint of microscopic diffusion anisotropy. Based on the amplitudes and their dependency on the inversion time, white matter partial volumes can be excluded as the sole source for this modulation, providing strong evidence for the detection of microscopic diffusion anisotropy in cortical gray matter. MA maps of healthy volunteers show considerably lower values in cortical gray matter compared with white matter.CONCLUSION: Microscopic diffusion anisotropy can be measured in human cortical brain matter, which could help to characterize the microstructure of healthy and pathological tissue.",

keywords = "Algorithms, Anisotropy, Brain/diagnostic imaging, Cerebrospinal Fluid, Diffusion Magnetic Resonance Imaging, Echo-Planar Imaging, Gray Matter/diagnostic imaging, Healthy Volunteers, Humans, Image Processing, Computer-Assisted, Phantoms, Imaging, White Matter/diagnostic imaging, Whole Body Imaging",

author = "Marco Lawrenz and J{\"u}rgen Finsterbusch",

note = "{\textcopyright} 2018 International Society for Magnetic Resonance in Medicine.",

year = "2019",

month = feb,

doi = "10.1002/mrm.27451",

language = "English",

volume = "81",

pages = "1296--1306",

journal = "MAGN RESON MED",

issn = "0740-3194",

publisher = "John Wiley and Sons Inc.",

number = "2",

}

RIS

TY - JOUR

T1 - Detection of microscopic diffusion anisotropy in human cortical gray matter in vivo with double diffusion encoding

AU - Lawrenz, Marco

AU - Finsterbusch, Jürgen

PY - 2019/2

Y1 - 2019/2

N2 - PURPOSE: To detect microscopic diffusion anisotropy in human cortical gray matter in vivo with double diffusion encoding experiments.METHODS: Double diffusion encoding experiments were performed on a 3 T whole-body MR system using echo-planar imaging. Angular double diffusion encoding measurements were acquired with 8 × 8 and 12 × 12 planar direction combinations and were analyzed in three regions of interest containing white matter, mostly cortical gray matter, and one having significant contributions from cerebrospinal fluid. Inversion with variable recovery times served to estimate and eliminate white matter partial volume effects. To investigate the influence of magnetic field inhomogeneities, experiments with gradient offsets and cross-term compensated diffusion weightings were performed. The MA index, a rotationally invariant measure of the microscopic diffusion anisotropy, was determined from measurements with 96 direction combinations.RESULTS: The angular signal modulation in the gray matter region of interest has two components, one being consistent, inter alia, with cross terms with field inhomogeneities while the other represents a signal difference between parallel/antiparallel and orthogonal direction combinations, ie, the fingerprint of microscopic diffusion anisotropy. Based on the amplitudes and their dependency on the inversion time, white matter partial volumes can be excluded as the sole source for this modulation, providing strong evidence for the detection of microscopic diffusion anisotropy in cortical gray matter. MA maps of healthy volunteers show considerably lower values in cortical gray matter compared with white matter.CONCLUSION: Microscopic diffusion anisotropy can be measured in human cortical brain matter, which could help to characterize the microstructure of healthy and pathological tissue.

AB - PURPOSE: To detect microscopic diffusion anisotropy in human cortical gray matter in vivo with double diffusion encoding experiments.METHODS: Double diffusion encoding experiments were performed on a 3 T whole-body MR system using echo-planar imaging. Angular double diffusion encoding measurements were acquired with 8 × 8 and 12 × 12 planar direction combinations and were analyzed in three regions of interest containing white matter, mostly cortical gray matter, and one having significant contributions from cerebrospinal fluid. Inversion with variable recovery times served to estimate and eliminate white matter partial volume effects. To investigate the influence of magnetic field inhomogeneities, experiments with gradient offsets and cross-term compensated diffusion weightings were performed. The MA index, a rotationally invariant measure of the microscopic diffusion anisotropy, was determined from measurements with 96 direction combinations.RESULTS: The angular signal modulation in the gray matter region of interest has two components, one being consistent, inter alia, with cross terms with field inhomogeneities while the other represents a signal difference between parallel/antiparallel and orthogonal direction combinations, ie, the fingerprint of microscopic diffusion anisotropy. Based on the amplitudes and their dependency on the inversion time, white matter partial volumes can be excluded as the sole source for this modulation, providing strong evidence for the detection of microscopic diffusion anisotropy in cortical gray matter. MA maps of healthy volunteers show considerably lower values in cortical gray matter compared with white matter.CONCLUSION: Microscopic diffusion anisotropy can be measured in human cortical brain matter, which could help to characterize the microstructure of healthy and pathological tissue.

KW - Algorithms

KW - Anisotropy

KW - Brain/diagnostic imaging

KW - Cerebrospinal Fluid

KW - Diffusion Magnetic Resonance Imaging

KW - Echo-Planar Imaging

KW - Gray Matter/diagnostic imaging

KW - Healthy Volunteers

KW - Humans

KW - Image Processing, Computer-Assisted

KW - Phantoms, Imaging

KW - White Matter/diagnostic imaging

KW - Whole Body Imaging

U2 - 10.1002/mrm.27451

DO - 10.1002/mrm.27451

M3 - SCORING: Journal article

C2 - 30206991

VL - 81

SP - 1296

EP - 1306

JO - MAGN RESON MED

JF - MAGN RESON MED

SN - 0740-3194

IS - 2

ER -