Detection of flow dynamic changes in 3D printed aneurysm models after treatment
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Detection of flow dynamic changes in 3D printed aneurysm models after treatment. / Sedlacik, Jan; Frölich, Andreas; Spallek, Johanna; Forkert, Nils D.; Werner, Franziska; Knopp, Tobias; Krause, Dieter; Fiehler, Jens; Buhk, Jan-Hendrik.
In: Int J Magn Part Imag, Vol. 3, No. 1, 2017.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Detection of flow dynamic changes in 3D printed aneurysm models after treatment
AU - Sedlacik, Jan
AU - Frölich, Andreas
AU - Spallek, Johanna
AU - Forkert, Nils D.
AU - Werner, Franziska
AU - Knopp, Tobias
AU - Krause, Dieter
AU - Fiehler, Jens
AU - Buhk, Jan-Hendrik
PY - 2017
Y1 - 2017
N2 - Treatment success and potential relapse of intracranial aneurysms need to be followed-up by regular imaging. However, the metallic material inside treated aneurysms can cause artifacts in MRI, CT and DSA possibly compromising clinical interpretation. Furthermore, frequent follow-ups with X-ray based imaging methods seriously increase the patient’s exposure to ionizing radiation. Thus, magnetic particle imaging (MPI) may be beneficial for patients with treated aneurysms. The purpose of this work was to demonstrate the capability of MPI to depict the change of the contrast agent dynamics of aneurysms after treatment. Realistic aneurysm models before and after treatment by different means were connected to a peristaltic pump with a physiologic flow (250 ml/min) and pulsation rate (70/min). Contrast agent curves over time were measured during injection of a 3 ml bolus within 3 s of an aqueous solution of 50 mmol(Fe)/L. MPI was able to detect the expected delay and dispersion of the contrast agent in the treated aneurysm as well as a less filling with contrast agent, if densely packed material was present inside the aneurysm. The delay was estimated based on the MPI contrast agent curves to be in the order of about 1 s. Thus, MPI is capable to detect delay and dispersion of the contrast agent dynamics after aneurysm treatment with clinical standard metallic material.
AB - Treatment success and potential relapse of intracranial aneurysms need to be followed-up by regular imaging. However, the metallic material inside treated aneurysms can cause artifacts in MRI, CT and DSA possibly compromising clinical interpretation. Furthermore, frequent follow-ups with X-ray based imaging methods seriously increase the patient’s exposure to ionizing radiation. Thus, magnetic particle imaging (MPI) may be beneficial for patients with treated aneurysms. The purpose of this work was to demonstrate the capability of MPI to depict the change of the contrast agent dynamics of aneurysms after treatment. Realistic aneurysm models before and after treatment by different means were connected to a peristaltic pump with a physiologic flow (250 ml/min) and pulsation rate (70/min). Contrast agent curves over time were measured during injection of a 3 ml bolus within 3 s of an aqueous solution of 50 mmol(Fe)/L. MPI was able to detect the expected delay and dispersion of the contrast agent in the treated aneurysm as well as a less filling with contrast agent, if densely packed material was present inside the aneurysm. The delay was estimated based on the MPI contrast agent curves to be in the order of about 1 s. Thus, MPI is capable to detect delay and dispersion of the contrast agent dynamics after aneurysm treatment with clinical standard metallic material.
KW - aneurysm
KW - intervention
KW - dynamic
M3 - SCORING: Journal article
VL - 3
JO - Int J Magn Part Imag
JF - Int J Magn Part Imag
SN - 2365-9033
IS - 1
ER -
