Detecting fearful and neutral faces
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Detecting fearful and neutral faces : BOLD latency differences in amygdala-hippocampal junction. / Reinders, A A T S; Gläscher, J; de Jong, J R; Willemsen, A T M; den Boer, J A; Büchel, C.
In: NEUROIMAGE, Vol. 33, No. 2, 01.11.2006, p. 805-14.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Detecting fearful and neutral faces
T2 - BOLD latency differences in amygdala-hippocampal junction
AU - Reinders, A A T S
AU - Gläscher, J
AU - de Jong, J R
AU - Willemsen, A T M
AU - den Boer, J A
AU - Büchel, C
PY - 2006/11/1
Y1 - 2006/11/1
N2 - Evolutionary survival and procreation are augmented if an individual organism quickly detects environmental threats and rapidly initiates defensive behavioral reactions. Thus, facial emotions signaling a potential threat, e.g., fear or anger, should be perceived rapidly and automatically, possibly through a subcortical processing route which includes the amygdala. Using event-related functional magnetic resonance imaging (fMRI), we investigated the time course of the response in the amygdala to neutral and fearful faces, which appear from dynamically decreasing random visual noise. We aimed to detect differences of the amygdala response between fearful and neutral faces by estimating the latency of the blood oxygenation level-dependent (BOLD) response. We found that bilateral amygdala-hippocampal junction activation occurred earlier for fearful than for neutral faces. Our findings support the theory of a dual route architecture in which the subcortical thalamic-hippocampal-amygdala route serves fast preconscious threat perception.
AB - Evolutionary survival and procreation are augmented if an individual organism quickly detects environmental threats and rapidly initiates defensive behavioral reactions. Thus, facial emotions signaling a potential threat, e.g., fear or anger, should be perceived rapidly and automatically, possibly through a subcortical processing route which includes the amygdala. Using event-related functional magnetic resonance imaging (fMRI), we investigated the time course of the response in the amygdala to neutral and fearful faces, which appear from dynamically decreasing random visual noise. We aimed to detect differences of the amygdala response between fearful and neutral faces by estimating the latency of the blood oxygenation level-dependent (BOLD) response. We found that bilateral amygdala-hippocampal junction activation occurred earlier for fearful than for neutral faces. Our findings support the theory of a dual route architecture in which the subcortical thalamic-hippocampal-amygdala route serves fast preconscious threat perception.
KW - Amygdala
KW - Brain Diseases
KW - Brain Mapping
KW - Cerebrovascular Circulation
KW - Facial Expression
KW - Fear
KW - Fourier Analysis
KW - Functional Laterality
KW - Hippocampus
KW - Humans
KW - Magnetic Resonance Imaging
KW - Oxygen
KW - Patient Selection
U2 - 10.1016/j.neuroimage.2006.06.052
DO - 10.1016/j.neuroimage.2006.06.052
M3 - SCORING: Journal article
C2 - 16952466
VL - 33
SP - 805
EP - 814
JO - NEUROIMAGE
JF - NEUROIMAGE
SN - 1053-8119
IS - 2
ER -