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Detectable Vesicular Stomatitis Virus (VSV)-Specific Humoral and Cellular Immune Responses Following VSV-Ebola Virus Vaccination in Humans

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Detectable Vesicular Stomatitis Virus (VSV)-Specific Humoral and Cellular Immune Responses Following VSV-Ebola Virus Vaccination in Humans. / Poetsch, Joseph H; Dahlke, Christine; Zinser, Madeleine E; Kasonta, Rahel; Lunemann, Sebastian; Rechtien, Anne; Ly, My L; Stubbe, Hans C; Krähling, Verena; Biedenkopf, Nadine; Eickmann, Markus; Fehling, Sarah K; Olearo, Flaminia; Strecker, Thomas; Sharma, Piyush; Lang, Karl S; Lohse, Ansgar W; Schmiedel, Stefan; Becker, Stephan; Addo, Marylyn M; VEBCON.

In: J INFECT DIS, Vol. 219, No. 4, 29.01.2019, p. 556-561.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Poetsch, JH, Dahlke, C, Zinser, ME, Kasonta, R, Lunemann, S, Rechtien, A, Ly, ML, Stubbe, HC, Krähling, V, Biedenkopf, N, Eickmann, M, Fehling, SK, Olearo, F, Strecker, T, Sharma, P, Lang, KS, Lohse, AW, Schmiedel, S, Becker, S, Addo, MM & VEBCON 2019, 'Detectable Vesicular Stomatitis Virus (VSV)-Specific Humoral and Cellular Immune Responses Following VSV-Ebola Virus Vaccination in Humans', J INFECT DIS, vol. 219, no. 4, pp. 556-561. https://doi.org/10.1093/infdis/jiy565

APA

Poetsch, J. H., Dahlke, C., Zinser, M. E., Kasonta, R., Lunemann, S., Rechtien, A., Ly, M. L., Stubbe, H. C., Krähling, V., Biedenkopf, N., Eickmann, M., Fehling, S. K., Olearo, F., Strecker, T., Sharma, P., Lang, K. S., Lohse, A. W., Schmiedel, S., Becker, S., ... VEBCON (2019). Detectable Vesicular Stomatitis Virus (VSV)-Specific Humoral and Cellular Immune Responses Following VSV-Ebola Virus Vaccination in Humans. J INFECT DIS, 219(4), 556-561. https://doi.org/10.1093/infdis/jiy565

Vancouver

Poetsch JH, Dahlke C, Zinser ME, Kasonta R, Lunemann S, Rechtien A et al. Detectable Vesicular Stomatitis Virus (VSV)-Specific Humoral and Cellular Immune Responses Following VSV-Ebola Virus Vaccination in Humans. J INFECT DIS. 2019 Jan 29;219(4):556-561. https://doi.org/10.1093/infdis/jiy565

Bibtex

@article{fffa3e4f4be04b11af972ab10e58165d,
title = "Detectable Vesicular Stomatitis Virus (VSV)-Specific Humoral and Cellular Immune Responses Following VSV-Ebola Virus Vaccination in Humans",
abstract = "In response to the Ebola virus (EBOV) crisis of 2013-2016, a recombinant vesicular stomatitis virus (VSV)-based EBOV vaccine was clinically tested (NCT02283099). A single-dose regimen of VSV-EBOV revealed a safe and immunogenic profile and demonstrated clinical efficacy. While EBOV-specific immune responses to this candidate vaccine have previously been investigated, limited human data on immunity to the VSV vector are available. Within the scope of a phase 1 study, we performed a comprehensive longitudinal analysis of adaptive immune responses to internal VSV proteins following VSV-EBOV immunization. While no preexisting immunity to the vector was observed, more than one-third of subjects developed VSV-specific cytotoxic T-lymphocyte responses and antibodies.",
keywords = "Journal Article",
author = "Poetsch, {Joseph H} and Christine Dahlke and Zinser, {Madeleine E} and Rahel Kasonta and Sebastian Lunemann and Anne Rechtien and Ly, {My L} and Stubbe, {Hans C} and Verena Kr{\"a}hling and Nadine Biedenkopf and Markus Eickmann and Fehling, {Sarah K} and Flaminia Olearo and Thomas Strecker and Piyush Sharma and Lang, {Karl S} and Lohse, {Ansgar W} and Stefan Schmiedel and Stephan Becker and Addo, {Marylyn M} and VEBCON",
year = "2019",
month = jan,
day = "29",
doi = "10.1093/infdis/jiy565",
language = "English",
volume = "219",
pages = "556--561",
journal = "J INFECT DIS",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "4",

}

RIS

TY - JOUR

T1 - Detectable Vesicular Stomatitis Virus (VSV)-Specific Humoral and Cellular Immune Responses Following VSV-Ebola Virus Vaccination in Humans

AU - Poetsch, Joseph H

AU - Dahlke, Christine

AU - Zinser, Madeleine E

AU - Kasonta, Rahel

AU - Lunemann, Sebastian

AU - Rechtien, Anne

AU - Ly, My L

AU - Stubbe, Hans C

AU - Krähling, Verena

AU - Biedenkopf, Nadine

AU - Eickmann, Markus

AU - Fehling, Sarah K

AU - Olearo, Flaminia

AU - Strecker, Thomas

AU - Sharma, Piyush

AU - Lang, Karl S

AU - Lohse, Ansgar W

AU - Schmiedel, Stefan

AU - Becker, Stephan

AU - Addo, Marylyn M

AU - VEBCON

PY - 2019/1/29

Y1 - 2019/1/29

N2 - In response to the Ebola virus (EBOV) crisis of 2013-2016, a recombinant vesicular stomatitis virus (VSV)-based EBOV vaccine was clinically tested (NCT02283099). A single-dose regimen of VSV-EBOV revealed a safe and immunogenic profile and demonstrated clinical efficacy. While EBOV-specific immune responses to this candidate vaccine have previously been investigated, limited human data on immunity to the VSV vector are available. Within the scope of a phase 1 study, we performed a comprehensive longitudinal analysis of adaptive immune responses to internal VSV proteins following VSV-EBOV immunization. While no preexisting immunity to the vector was observed, more than one-third of subjects developed VSV-specific cytotoxic T-lymphocyte responses and antibodies.

AB - In response to the Ebola virus (EBOV) crisis of 2013-2016, a recombinant vesicular stomatitis virus (VSV)-based EBOV vaccine was clinically tested (NCT02283099). A single-dose regimen of VSV-EBOV revealed a safe and immunogenic profile and demonstrated clinical efficacy. While EBOV-specific immune responses to this candidate vaccine have previously been investigated, limited human data on immunity to the VSV vector are available. Within the scope of a phase 1 study, we performed a comprehensive longitudinal analysis of adaptive immune responses to internal VSV proteins following VSV-EBOV immunization. While no preexisting immunity to the vector was observed, more than one-third of subjects developed VSV-specific cytotoxic T-lymphocyte responses and antibodies.

KW - Journal Article

U2 - 10.1093/infdis/jiy565

DO - 10.1093/infdis/jiy565

M3 - SCORING: Journal article

C2 - 30452666

VL - 219

SP - 556

EP - 561

JO - J INFECT DIS

JF - J INFECT DIS

SN - 0022-1899

IS - 4

ER -