Detailed stratified GWAS analysis for severe COVID-19 in four European populations
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Detailed stratified GWAS analysis for severe COVID-19 in four European populations. / Degenhardt, Frauke; Ellinghaus, David; Juzenas, Simonas; Lerga-Jaso, Jon; Wendorff, Mareike; Maya-Miles, Douglas; Uellendahl-Werth, Florian; ElAbd, Hesham; Rühlemann, Malte C; Arora, Jatin; Özer, Onur; Lenning, Ole Bernt; Myhre, Ronny; Vadla, May Sissel; Wacker, Eike M; Wienbrandt, Lars; Blandino Ortiz, Aaron; de Salazar, Adolfo; Garrido Chercoles, Adolfo; Palom, Adriana; Ruiz, Agustín; Garcia-Fernandez, Alba-Estela; Blanco-Grau, Albert; Mantovani, Alberto; Zanella, Alberto; Holten, Aleksander Rygh; Mayer, Alena; Bandera, Alessandra; Cherubini, Alessandro; Protti, Alessandro; Aghemo, Alessio; Gerussi, Alessio; Ramirez, Alfredo; Braun, Alice; Nebel, Almut; Barreira, Ana; Lleo, Ana; Teles, Ana; Kildal, Anders Benjamin; Biondi, Andrea; Caballero-Garralda, Andrea; Ganna, Andrea; Gori, Andrea; Glück, Andreas; Lind, Andreas; Tanck, Anja; Hinney, Anke; Carreras Nolla, Anna; Fracanzani, Anna Ludovica; Peschuck, Anna; Cavallero, Annalisa; Dyrhol-Riise, Anne Ma; Ruello, Antonella; Julià, Antonio; Muscatello, Antonio; Pesenti, Antonio; Voza, Antonio; Rando-Segura, Ariadna; Solier, Aurora; Schmidt, Axel; Cortes, Beatriz; Mateos, Beatriz; Nafria-Jimenez, Beatriz; Schaefer, Benedikt; Jensen, Björn; Bellinghausen, Carla; Maj, Carlo; Ferrando, Carlos; de la Horra, Carmen; Quereda, Carmen; Skurk, Carsten; Thibeault, Charlotte; Scollo, Chiara; Herr, Christian; Spinner, Christoph D; Gassner, Christoph; Lange, Christoph; Hu, Cinzia; Paccapelo, Cinzia; Lehmann, Clara; Angelini, Claudio; Cappadona, Claudio; Azuure, Clinton; Bianco, Cristiana; Cea, Cristina; Sancho, Cristina; Hoff, Dag Arne Lihaug; Galimberti, Daniela; Prati, Daniele; Haschka, David; Jiménez, David; Pestaña, David; Toapanta, David; Muñiz-Diaz, Eduardo; Azzolini, Elena; Sandoval, Elena; Binatti, Eleonora; Scarpini, Elio; Helbig, Elisa T; Casalone, Elisabetta; Urrechaga, Eloisa; Paraboschi, Elvezia Maria; Pontali, Emanuele; Reverter, Enric; Calderón, Enrique J; Navas, Enrique; Solligård, Erik; Contro, Ernesto; Arana-Arri, Eunate; Aziz, Fátima; Garcia, Federico; García Sánchez, Félix; Ceriotti, Ferruccio; Martinelli-Boneschi, Filippo; Peyvandi, Flora; Kurth, Florian; Blasi, Francesco; Malvestiti, Francesco; Medrano, Francisco J; Mesonero, Francisco; Rodriguez-Frias, Francisco; Hanses, Frank; Müller, Fredrik; Hemmrich-Stanisak, Georg; Bellani, Giacomo; Grasselli, Giacomo; Pezzoli, Gianni; Costantino, Giorgio; Albano, Giovanni; Cardamone, Giulia; Bellelli, Giuseppe; Citerio, Giuseppe; Foti, Giuseppe; Lamorte, Giuseppe; Matullo, Giuseppe; Baselli, Guido; Kurihara, Hayato; Neb, Holger; My, Ilaria; Kurth, Ingo; Hernández, Isabel; Pink, Isabell; de Rojas, Itziar; Galván-Femenia, Iván; Holter, Jan Cato; Afset, Jan Egil; Heyckendorf, Jan; Kässens, Jan; Damås, Jan Kristian; Rybniker, Jan; Altmüller, Janine; Ampuero, Javier; Martín, Javier; Erdmann, Jeanette; Banales, Jesus M; Badia, Joan Ramon; Dopazo, Joaquin; Schneider, Jochen; Bergan, Jonas; Barretina, Jordi; Walter, Jörn; Hernández Quero, Jose; Goikoetxea, Josune; Delgado, Juan; Guerrero, Juan M; Fazaal, Julia; Kraft, Julia; Schröder, Julia; Risnes, Kari; Banasik, Karina; Müller, Karl Erik; Gaede, Karoline I; Garcia-Etxebarria, Koldo; Tonby, Kristian; Heggelund, Lars; Izquierdo-Sanchez, Laura; Bettini, Laura Rachele; Sumoy, Lauro; Sander, Leif Erik; Lippert, Lena J; Terranova, Leonardo; Nkambule, Lindokuhle; Knopp, Lisa; Gustad, Lise Tuset; Garbarino, Lucia; Santoro, Luigi; Téllez, Luis; Roade, Luisa; Ostadreza, Mahnoosh; Intxausti, Maider; Kogevinas, Manolis; Riveiro-Barciela, Mar; Berger, Marc M; Schaefer, Marco; Niemi, Mari E K; Gutiérrez-Stampa, María A; Carrabba, Maria; Figuera Basso, Maria E; Valsecchi, Maria Grazia; Hernandez-Tejero, María; Vehreschild, Maria J G T; Manunta, Maria; Acosta-Herrera, Marialbert; D'Angiò, Mariella; Baldini, Marina; Cazzaniga, Marina; Grimsrud, Marit M; Cornberg, Markus; Nöthen, Markus M; Marquié, Marta; Castoldi, Massimo; Cordioli, Mattia; Cecconi, Maurizio; D'Amato, Mauro; Augustin, Max; Tomasi, Melissa; Boada, Mercè; Dreher, Michael; Seilmaier, Michael J; Joannidis, Michael; Wittig, Michael; Mazzocco, Michela; Ciccarelli, Michele; Rodríguez-Gandía, Miguel; Bocciolone, Monica; Miozzo, Monica; Imaz Ayo, Natale; Blay, Natalia; Chueca, Natalia; Montano, Nicola; Braun, Nicole; Ludwig, Nicole; Marx, Nikolaus; Martínez, Nilda; Cornely, Oliver A; Witzke, Oliver; Palmieri, Orazio; Faverio, Paola; Preatoni, Paoletta; Bonfanti, Paolo; Omodei, Paolo; Tentorio, Paolo; Castro, Pedro; Rodrigues, Pedro M; España, Pedro Pablo; Hoffmann, Per; Rosenstiel, Philip; Schommers, Philipp; Suwalski, Phillip; de Pablo, Raúl; Ferrer, Ricard; Bals, Robert; Gualtierotti, Roberta; Gallego-Durán, Rocío; Nieto, Rosa; Carpani, Rossana; Morilla, Rubén; Badalamenti, Salvatore; Haider, Sammra; Ciesek, Sandra; May, Sandra; Bombace, Sara; Marsal, Sara; Pigazzini, Sara; Klein, Sebastian; Pelusi, Serena; Wilfling, Sibylle; Bosari, Silvano; Volland, Sonja; Brunak, Søren; Raychaudhuri, Soumya; Schreiber, Stefan; Heilmann-Heimbach, Stefanie; Aliberti, Stefano; Ripke, Stephan; Dudman, Susanne; Wesse, Tanja; Zheng, Tenghao; Bahmer, Thomas; Eggermann, Thomas; Illig, Thomas; Brenner, Thorsten; Pumarola, Tomas; Feldt, Torsten; Folseraas, Trine; Gonzalez Cejudo, Trinidad; Landmesser, Ulf; Protzer, Ulrike; Hehr, Ute; Rimoldi, Valeria; Monzani, Valter; Skogen, Vegard; Keitel, Verena; Kopfnagel, Verena; Friaza, Vicente; Andrade, Victor; Moreno, Victor; Albrecht, Wolfgang; Peter, Wolfgang; Poller, Wolfgang; Farre, Xavier; Yi, Xiaoli; Wang, Xiaomin; Khodamoradi, Yascha; Karadeniz, Zehra; Latiano, Anna; Goerg, Siegfried; Bacher, Petra; Koehler, Philipp; Tran, Florian; Zoller, Heinz; Schulte, Eva C; Heidecker, Bettina; Ludwig, Kerstin U; Fernández, Javier; Romero-Gómez, Manuel; Albillos, Agustín; Invernizzi, Pietro; Buti, Maria; Duga, Stefano; Bujanda, Luis; Hov, Johannes R; Lenz, Tobias L; Asselta, Rosanna; de Cid, Rafael; Valenti, Luca; Karlsen, Tom H; Cáceres, Mario; Franke, Andre; COVICAT study group, Aachen Study (COVAS).
In: HUM MOL GENET, Vol. 31, No. 23, 28.11.2022, p. 3945-3966.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Detailed stratified GWAS analysis for severe COVID-19 in four European populations
AU - Degenhardt, Frauke
AU - Ellinghaus, David
AU - Juzenas, Simonas
AU - Lerga-Jaso, Jon
AU - Wendorff, Mareike
AU - Maya-Miles, Douglas
AU - Uellendahl-Werth, Florian
AU - ElAbd, Hesham
AU - Rühlemann, Malte C
AU - Arora, Jatin
AU - Özer, Onur
AU - Lenning, Ole Bernt
AU - Myhre, Ronny
AU - Vadla, May Sissel
AU - Wacker, Eike M
AU - Wienbrandt, Lars
AU - Blandino Ortiz, Aaron
AU - de Salazar, Adolfo
AU - Garrido Chercoles, Adolfo
AU - Palom, Adriana
AU - Ruiz, Agustín
AU - Garcia-Fernandez, Alba-Estela
AU - Blanco-Grau, Albert
AU - Mantovani, Alberto
AU - Zanella, Alberto
AU - Holten, Aleksander Rygh
AU - Mayer, Alena
AU - Bandera, Alessandra
AU - Cherubini, Alessandro
AU - Protti, Alessandro
AU - Aghemo, Alessio
AU - Gerussi, Alessio
AU - Ramirez, Alfredo
AU - Braun, Alice
AU - Nebel, Almut
AU - Barreira, Ana
AU - Lleo, Ana
AU - Teles, Ana
AU - Kildal, Anders Benjamin
AU - Biondi, Andrea
AU - Caballero-Garralda, Andrea
AU - Ganna, Andrea
AU - Gori, Andrea
AU - Glück, Andreas
AU - Lind, Andreas
AU - Tanck, Anja
AU - Hinney, Anke
AU - Carreras Nolla, Anna
AU - Fracanzani, Anna Ludovica
AU - Peschuck, Anna
AU - Cavallero, Annalisa
AU - Dyrhol-Riise, Anne Ma
AU - Ruello, Antonella
AU - Julià, Antonio
AU - Muscatello, Antonio
AU - Pesenti, Antonio
AU - Voza, Antonio
AU - Rando-Segura, Ariadna
AU - Solier, Aurora
AU - Schmidt, Axel
AU - Cortes, Beatriz
AU - Mateos, Beatriz
AU - Nafria-Jimenez, Beatriz
AU - Schaefer, Benedikt
AU - Jensen, Björn
AU - Bellinghausen, Carla
AU - Maj, Carlo
AU - Ferrando, Carlos
AU - de la Horra, Carmen
AU - Quereda, Carmen
AU - Skurk, Carsten
AU - Thibeault, Charlotte
AU - Scollo, Chiara
AU - Herr, Christian
AU - Spinner, Christoph D
AU - Gassner, Christoph
AU - Lange, Christoph
AU - Hu, Cinzia
AU - Paccapelo, Cinzia
AU - Lehmann, Clara
AU - Angelini, Claudio
AU - Cappadona, Claudio
AU - Azuure, Clinton
AU - Bianco, Cristiana
AU - Cea, Cristina
AU - Sancho, Cristina
AU - Hoff, Dag Arne Lihaug
AU - Galimberti, Daniela
AU - Prati, Daniele
AU - Haschka, David
AU - Jiménez, David
AU - Pestaña, David
AU - Toapanta, David
AU - Muñiz-Diaz, Eduardo
AU - Azzolini, Elena
AU - Sandoval, Elena
AU - Binatti, Eleonora
AU - Scarpini, Elio
AU - Helbig, Elisa T
AU - Casalone, Elisabetta
AU - Urrechaga, Eloisa
AU - Paraboschi, Elvezia Maria
AU - Pontali, Emanuele
AU - Reverter, Enric
AU - Calderón, Enrique J
AU - Navas, Enrique
AU - Solligård, Erik
AU - Contro, Ernesto
AU - Arana-Arri, Eunate
AU - Aziz, Fátima
AU - Garcia, Federico
AU - García Sánchez, Félix
AU - Ceriotti, Ferruccio
AU - Martinelli-Boneschi, Filippo
AU - Peyvandi, Flora
AU - Kurth, Florian
AU - Blasi, Francesco
AU - Malvestiti, Francesco
AU - Medrano, Francisco J
AU - Mesonero, Francisco
AU - Rodriguez-Frias, Francisco
AU - Hanses, Frank
AU - Müller, Fredrik
AU - Hemmrich-Stanisak, Georg
AU - Bellani, Giacomo
AU - Grasselli, Giacomo
AU - Pezzoli, Gianni
AU - Costantino, Giorgio
AU - Albano, Giovanni
AU - Cardamone, Giulia
AU - Bellelli, Giuseppe
AU - Citerio, Giuseppe
AU - Foti, Giuseppe
AU - Lamorte, Giuseppe
AU - Matullo, Giuseppe
AU - Baselli, Guido
AU - Kurihara, Hayato
AU - Neb, Holger
AU - My, Ilaria
AU - Kurth, Ingo
AU - Hernández, Isabel
AU - Pink, Isabell
AU - de Rojas, Itziar
AU - Galván-Femenia, Iván
AU - Holter, Jan Cato
AU - Afset, Jan Egil
AU - Heyckendorf, Jan
AU - Kässens, Jan
AU - Damås, Jan Kristian
AU - Rybniker, Jan
AU - Altmüller, Janine
AU - Ampuero, Javier
AU - Martín, Javier
AU - Erdmann, Jeanette
AU - Banales, Jesus M
AU - Badia, Joan Ramon
AU - Dopazo, Joaquin
AU - Schneider, Jochen
AU - Bergan, Jonas
AU - Barretina, Jordi
AU - Walter, Jörn
AU - Hernández Quero, Jose
AU - Goikoetxea, Josune
AU - Delgado, Juan
AU - Guerrero, Juan M
AU - Fazaal, Julia
AU - Kraft, Julia
AU - Schröder, Julia
AU - Risnes, Kari
AU - Banasik, Karina
AU - Müller, Karl Erik
AU - Gaede, Karoline I
AU - Garcia-Etxebarria, Koldo
AU - Tonby, Kristian
AU - Heggelund, Lars
AU - Izquierdo-Sanchez, Laura
AU - Bettini, Laura Rachele
AU - Sumoy, Lauro
AU - Sander, Leif Erik
AU - Lippert, Lena J
AU - Terranova, Leonardo
AU - Nkambule, Lindokuhle
AU - Knopp, Lisa
AU - Gustad, Lise Tuset
AU - Garbarino, Lucia
AU - Santoro, Luigi
AU - Téllez, Luis
AU - Roade, Luisa
AU - Ostadreza, Mahnoosh
AU - Intxausti, Maider
AU - Kogevinas, Manolis
AU - Riveiro-Barciela, Mar
AU - Berger, Marc M
AU - Schaefer, Marco
AU - Niemi, Mari E K
AU - Gutiérrez-Stampa, María A
AU - Carrabba, Maria
AU - Figuera Basso, Maria E
AU - Valsecchi, Maria Grazia
AU - Hernandez-Tejero, María
AU - Vehreschild, Maria J G T
AU - Manunta, Maria
AU - Acosta-Herrera, Marialbert
AU - D'Angiò, Mariella
AU - Baldini, Marina
AU - Cazzaniga, Marina
AU - Grimsrud, Marit M
AU - Cornberg, Markus
AU - Nöthen, Markus M
AU - Marquié, Marta
AU - Castoldi, Massimo
AU - Cordioli, Mattia
AU - Cecconi, Maurizio
AU - D'Amato, Mauro
AU - Augustin, Max
AU - Tomasi, Melissa
AU - Boada, Mercè
AU - Dreher, Michael
AU - Seilmaier, Michael J
AU - Joannidis, Michael
AU - Wittig, Michael
AU - Mazzocco, Michela
AU - Ciccarelli, Michele
AU - Rodríguez-Gandía, Miguel
AU - Bocciolone, Monica
AU - Miozzo, Monica
AU - Imaz Ayo, Natale
AU - Blay, Natalia
AU - Chueca, Natalia
AU - Montano, Nicola
AU - Braun, Nicole
AU - Ludwig, Nicole
AU - Marx, Nikolaus
AU - Martínez, Nilda
AU - Cornely, Oliver A
AU - Witzke, Oliver
AU - Palmieri, Orazio
AU - Faverio, Paola
AU - Preatoni, Paoletta
AU - Bonfanti, Paolo
AU - Omodei, Paolo
AU - Tentorio, Paolo
AU - Castro, Pedro
AU - Rodrigues, Pedro M
AU - España, Pedro Pablo
AU - Hoffmann, Per
AU - Rosenstiel, Philip
AU - Schommers, Philipp
AU - Suwalski, Phillip
AU - de Pablo, Raúl
AU - Ferrer, Ricard
AU - Bals, Robert
AU - Gualtierotti, Roberta
AU - Gallego-Durán, Rocío
AU - Nieto, Rosa
AU - Carpani, Rossana
AU - Morilla, Rubén
AU - Badalamenti, Salvatore
AU - Haider, Sammra
AU - Ciesek, Sandra
AU - May, Sandra
AU - Bombace, Sara
AU - Marsal, Sara
AU - Pigazzini, Sara
AU - Klein, Sebastian
AU - Pelusi, Serena
AU - Wilfling, Sibylle
AU - Bosari, Silvano
AU - Volland, Sonja
AU - Brunak, Søren
AU - Raychaudhuri, Soumya
AU - Schreiber, Stefan
AU - Heilmann-Heimbach, Stefanie
AU - Aliberti, Stefano
AU - Ripke, Stephan
AU - Dudman, Susanne
AU - Wesse, Tanja
AU - Zheng, Tenghao
AU - Bahmer, Thomas
AU - Eggermann, Thomas
AU - Illig, Thomas
AU - Brenner, Thorsten
AU - Pumarola, Tomas
AU - Feldt, Torsten
AU - Folseraas, Trine
AU - Gonzalez Cejudo, Trinidad
AU - Landmesser, Ulf
AU - Protzer, Ulrike
AU - Hehr, Ute
AU - Rimoldi, Valeria
AU - Monzani, Valter
AU - Skogen, Vegard
AU - Keitel, Verena
AU - Kopfnagel, Verena
AU - Friaza, Vicente
AU - Andrade, Victor
AU - Moreno, Victor
AU - Albrecht, Wolfgang
AU - Peter, Wolfgang
AU - Poller, Wolfgang
AU - Farre, Xavier
AU - Yi, Xiaoli
AU - Wang, Xiaomin
AU - Khodamoradi, Yascha
AU - Karadeniz, Zehra
AU - Latiano, Anna
AU - Goerg, Siegfried
AU - Bacher, Petra
AU - Koehler, Philipp
AU - Tran, Florian
AU - Zoller, Heinz
AU - Schulte, Eva C
AU - Heidecker, Bettina
AU - Ludwig, Kerstin U
AU - Fernández, Javier
AU - Romero-Gómez, Manuel
AU - Albillos, Agustín
AU - Invernizzi, Pietro
AU - Buti, Maria
AU - Duga, Stefano
AU - Bujanda, Luis
AU - Hov, Johannes R
AU - Lenz, Tobias L
AU - Asselta, Rosanna
AU - de Cid, Rafael
AU - Valenti, Luca
AU - Karlsen, Tom H
AU - Cáceres, Mario
AU - Franke, Andre
AU - COVICAT study group, Aachen Study (COVAS)
N1 - © The Author(s) 2022. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
PY - 2022/11/28
Y1 - 2022/11/28
N2 - Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease mechanisms. Here, we describe an extended genome-wide association meta-analysis of a well-characterized cohort of 3255 COVID-19 patients with respiratory failure and 12 488 population controls from Italy, Spain, Norway and Germany/Austria, including stratified analyses based on age, sex and disease severity, as well as targeted analyses of chromosome Y haplotypes, the human leukocyte antigen region and the SARS-CoV-2 peptidome. By inversion imputation, we traced a reported association at 17q21.31 to a ~0.9-Mb inversion polymorphism that creates two highly differentiated haplotypes and characterized the potential effects of the inversion in detail. Our data, together with the 5th release of summary statistics from the COVID-19 Host Genetics Initiative including non-Caucasian individuals, also identified a new locus at 19q13.33, including NAPSA, a gene which is expressed primarily in alveolar cells responsible for gas exchange in the lung.
AB - Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease mechanisms. Here, we describe an extended genome-wide association meta-analysis of a well-characterized cohort of 3255 COVID-19 patients with respiratory failure and 12 488 population controls from Italy, Spain, Norway and Germany/Austria, including stratified analyses based on age, sex and disease severity, as well as targeted analyses of chromosome Y haplotypes, the human leukocyte antigen region and the SARS-CoV-2 peptidome. By inversion imputation, we traced a reported association at 17q21.31 to a ~0.9-Mb inversion polymorphism that creates two highly differentiated haplotypes and characterized the potential effects of the inversion in detail. Our data, together with the 5th release of summary statistics from the COVID-19 Host Genetics Initiative including non-Caucasian individuals, also identified a new locus at 19q13.33, including NAPSA, a gene which is expressed primarily in alveolar cells responsible for gas exchange in the lung.
KW - Humans
KW - COVID-19/genetics
KW - SARS-CoV-2/genetics
KW - Genome-Wide Association Study
KW - Haplotypes
KW - Polymorphism, Genetic
U2 - 10.1093/hmg/ddac158
DO - 10.1093/hmg/ddac158
M3 - SCORING: Journal article
C2 - 35848942
VL - 31
SP - 3945
EP - 3966
JO - HUM MOL GENET
JF - HUM MOL GENET
SN - 0964-6906
IS - 23
ER -