Depressive mood mediates the influence of social support on health-related quality of life in elderly, multimorbid patients
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Depressive mood mediates the influence of social support on health-related quality of life in elderly, multimorbid patients. / Wicke, Felix S; Güthlin, Corina; Mergenthal, Karola; Gensichen, Jochen; Löffler, Christin; Bickel, Horst; Maier, Wolfgang; Riedel-Heller, Steffi G; Weyerer, Siegfried; Wiese, Birgitt; König, Hans-Helmut; Schön, Gerhard; Hansen, Heike; Bussche van den, Hendrik; Scherer, Martin; Dahlhaus, Anne.
In: BMC FAM PRACT, Vol. 15, 2014, p. 62.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Depressive mood mediates the influence of social support on health-related quality of life in elderly, multimorbid patients
AU - Wicke, Felix S
AU - Güthlin, Corina
AU - Mergenthal, Karola
AU - Gensichen, Jochen
AU - Löffler, Christin
AU - Bickel, Horst
AU - Maier, Wolfgang
AU - Riedel-Heller, Steffi G
AU - Weyerer, Siegfried
AU - Wiese, Birgitt
AU - König, Hans-Helmut
AU - Schön, Gerhard
AU - Hansen, Heike
AU - Bussche van den, Hendrik
AU - Scherer, Martin
AU - Dahlhaus, Anne
PY - 2014
Y1 - 2014
N2 - BACKGROUND: It is not well established how psychosocial factors like social support and depression affect health-related quality of life in multimorbid and elderly patients. We investigated whether depressive mood mediates the influence of social support on health-related quality of life.METHODS: Cross-sectional data of 3,189 multimorbid patients from the baseline assessment of the German MultiCare cohort study were used. Mediation was tested using the approach described by Baron and Kenny based on multiple linear regression, and controlling for socioeconomic variables and burden of multimorbidity.RESULTS: Mediation analyses confirmed that depressive mood mediates the influence of social support on health-related quality of life (Sobel's p < 0.001). Multiple linear regression showed that the influence of depressive mood (β = -0.341, p < 0.01) on health-related quality of life is greater than the influence of multimorbidity (β = -0.234, p < 0.01).CONCLUSION: Social support influences health-related quality of life, but this association is strongly mediated by depressive mood. Depression should be taken into consideration in research on multimorbidity, and clinicians should be aware of its importance when caring for multimorbid patients.TRIAL REGISTRATION: ISRCTN89818205.
AB - BACKGROUND: It is not well established how psychosocial factors like social support and depression affect health-related quality of life in multimorbid and elderly patients. We investigated whether depressive mood mediates the influence of social support on health-related quality of life.METHODS: Cross-sectional data of 3,189 multimorbid patients from the baseline assessment of the German MultiCare cohort study were used. Mediation was tested using the approach described by Baron and Kenny based on multiple linear regression, and controlling for socioeconomic variables and burden of multimorbidity.RESULTS: Mediation analyses confirmed that depressive mood mediates the influence of social support on health-related quality of life (Sobel's p < 0.001). Multiple linear regression showed that the influence of depressive mood (β = -0.341, p < 0.01) on health-related quality of life is greater than the influence of multimorbidity (β = -0.234, p < 0.01).CONCLUSION: Social support influences health-related quality of life, but this association is strongly mediated by depressive mood. Depression should be taken into consideration in research on multimorbidity, and clinicians should be aware of its importance when caring for multimorbid patients.TRIAL REGISTRATION: ISRCTN89818205.
U2 - 10.1186/1471-2296-15-62
DO - 10.1186/1471-2296-15-62
M3 - SCORING: Journal article
C2 - 24708815
VL - 15
SP - 62
JO - BMC PRIM CARE
JF - BMC PRIM CARE
SN - 1471-2296
ER -
