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Depression, non-fatal stroke and all-cause mortality in old age: a prospective cohort study of primary care patients

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Depression, non-fatal stroke and all-cause mortality in old age: a prospective cohort study of primary care patients. / Köhler, Sebastian; Verhey, Frans; Weyerer, Siegfried; Wiese, Birgitt; Heser, Kathrin; Wagner, Michael; Pentzek, Michael; Fuchs, Angela; Köhler, Mirjam; Bachmann, Cadja; Riedel Heller, Steffi G; Luppa, Melanie; Eifflaender-Gorfer, Sandra; Werle, Jochen; Bickel, Horst; Mösch, Edelgard; König, Hans-Helmut; Brettschneider, Christian; Scherer, Martin; Maier, Wolfgang.

In: J AFFECT DISORDERS, Vol. 150, No. 1, 15.08.2013, p. 63-9.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Köhler, S, Verhey, F, Weyerer, S, Wiese, B, Heser, K, Wagner, M, Pentzek, M, Fuchs, A, Köhler, M, Bachmann, C, Riedel Heller, SG, Luppa, M, Eifflaender-Gorfer, S, Werle, J, Bickel, H, Mösch, E, König, H-H, Brettschneider, C, Scherer, M & Maier, W 2013, 'Depression, non-fatal stroke and all-cause mortality in old age: a prospective cohort study of primary care patients', J AFFECT DISORDERS, vol. 150, no. 1, pp. 63-9. https://doi.org/10.1016/j.jad.2013.02.020

APA

Köhler, S., Verhey, F., Weyerer, S., Wiese, B., Heser, K., Wagner, M., Pentzek, M., Fuchs, A., Köhler, M., Bachmann, C., Riedel Heller, S. G., Luppa, M., Eifflaender-Gorfer, S., Werle, J., Bickel, H., Mösch, E., König, H-H., Brettschneider, C., Scherer, M., & Maier, W. (2013). Depression, non-fatal stroke and all-cause mortality in old age: a prospective cohort study of primary care patients. J AFFECT DISORDERS, 150(1), 63-9. https://doi.org/10.1016/j.jad.2013.02.020

Vancouver

Köhler S, Verhey F, Weyerer S, Wiese B, Heser K, Wagner M et al. Depression, non-fatal stroke and all-cause mortality in old age: a prospective cohort study of primary care patients. J AFFECT DISORDERS. 2013 Aug 15;150(1):63-9. https://doi.org/10.1016/j.jad.2013.02.020

Bibtex

@article{fd98b3fb05804a10843f3c0a3a794e00,
title = "Depression, non-fatal stroke and all-cause mortality in old age: a prospective cohort study of primary care patients",
abstract = "BACKGROUND: Depression is a risk factor for stroke and mortality but whether this also holds into old age is uncertain. We therefore studied the association of depression with the risk for non-fatal stroke and all-cause mortality in very old age.METHODS: A representative sample of 3085 primary care patients aged ≥ 75 years were serially assessed during a 6-year follow-up. The relation between depression (Geriatric Depression Scale >6, n=261) and relevant covariates including vascular risk factors and disease, functional and mild cognitive impairment and ApoE genotype on primary care givers information of incident stroke (n=209) and mortality (n=647) were assessed by Cox regression and by competing risk regressions.RESULTS: Depression was not independently associated with incident stroke in fully adjusted models that treated death as the competing event (subdistribution hazard ratio=0.80, 95% confidence interval=0.47 to 1.36). The risk associated with depression was similar for men and women, and for age groups 75-79, 80-84 and ≥ 85 years. In contrast, depression increased all-cause mortality rates, even after adjusting for a range of confounders (hazard ratio=1.31, 95% confidence interval=1.03 to 1.67).LIMITATIONS: We have no information on past depressive episodes and cause of death.CONCLUSIONS: In contrast to reports in younger populations, depression does not appear to increase stroke risk among the old and very old, but continuous to be a risk factor for all-cause mortality.",
keywords = "Age Distribution, Aged, Aged, 80 and over, Cause of Death, Depression, Female, Follow-Up Studies, Germany, Humans, Incidence, Male, Models, Statistical, Primary Health Care, Prospective Studies, Risk Factors, Sex Distribution, Stroke",
author = "Sebastian K{\"o}hler and Frans Verhey and Siegfried Weyerer and Birgitt Wiese and Kathrin Heser and Michael Wagner and Michael Pentzek and Angela Fuchs and Mirjam K{\"o}hler and Cadja Bachmann and {Riedel Heller}, {Steffi G} and Melanie Luppa and Sandra Eifflaender-Gorfer and Jochen Werle and Horst Bickel and Edelgard M{\"o}sch and Hans-Helmut K{\"o}nig and Christian Brettschneider and Martin Scherer and Wolfgang Maier",
note = "Copyright {\textcopyright} 2013 Elsevier B.V. All rights reserved.",
year = "2013",
month = aug,
day = "15",
doi = "10.1016/j.jad.2013.02.020",
language = "English",
volume = "150",
pages = "63--9",
journal = "J AFFECT DISORDERS",
issn = "0165-0327",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - Depression, non-fatal stroke and all-cause mortality in old age: a prospective cohort study of primary care patients

AU - Köhler, Sebastian

AU - Verhey, Frans

AU - Weyerer, Siegfried

AU - Wiese, Birgitt

AU - Heser, Kathrin

AU - Wagner, Michael

AU - Pentzek, Michael

AU - Fuchs, Angela

AU - Köhler, Mirjam

AU - Bachmann, Cadja

AU - Riedel Heller, Steffi G

AU - Luppa, Melanie

AU - Eifflaender-Gorfer, Sandra

AU - Werle, Jochen

AU - Bickel, Horst

AU - Mösch, Edelgard

AU - König, Hans-Helmut

AU - Brettschneider, Christian

AU - Scherer, Martin

AU - Maier, Wolfgang

N1 - Copyright © 2013 Elsevier B.V. All rights reserved.

PY - 2013/8/15

Y1 - 2013/8/15

N2 - BACKGROUND: Depression is a risk factor for stroke and mortality but whether this also holds into old age is uncertain. We therefore studied the association of depression with the risk for non-fatal stroke and all-cause mortality in very old age.METHODS: A representative sample of 3085 primary care patients aged ≥ 75 years were serially assessed during a 6-year follow-up. The relation between depression (Geriatric Depression Scale >6, n=261) and relevant covariates including vascular risk factors and disease, functional and mild cognitive impairment and ApoE genotype on primary care givers information of incident stroke (n=209) and mortality (n=647) were assessed by Cox regression and by competing risk regressions.RESULTS: Depression was not independently associated with incident stroke in fully adjusted models that treated death as the competing event (subdistribution hazard ratio=0.80, 95% confidence interval=0.47 to 1.36). The risk associated with depression was similar for men and women, and for age groups 75-79, 80-84 and ≥ 85 years. In contrast, depression increased all-cause mortality rates, even after adjusting for a range of confounders (hazard ratio=1.31, 95% confidence interval=1.03 to 1.67).LIMITATIONS: We have no information on past depressive episodes and cause of death.CONCLUSIONS: In contrast to reports in younger populations, depression does not appear to increase stroke risk among the old and very old, but continuous to be a risk factor for all-cause mortality.

AB - BACKGROUND: Depression is a risk factor for stroke and mortality but whether this also holds into old age is uncertain. We therefore studied the association of depression with the risk for non-fatal stroke and all-cause mortality in very old age.METHODS: A representative sample of 3085 primary care patients aged ≥ 75 years were serially assessed during a 6-year follow-up. The relation between depression (Geriatric Depression Scale >6, n=261) and relevant covariates including vascular risk factors and disease, functional and mild cognitive impairment and ApoE genotype on primary care givers information of incident stroke (n=209) and mortality (n=647) were assessed by Cox regression and by competing risk regressions.RESULTS: Depression was not independently associated with incident stroke in fully adjusted models that treated death as the competing event (subdistribution hazard ratio=0.80, 95% confidence interval=0.47 to 1.36). The risk associated with depression was similar for men and women, and for age groups 75-79, 80-84 and ≥ 85 years. In contrast, depression increased all-cause mortality rates, even after adjusting for a range of confounders (hazard ratio=1.31, 95% confidence interval=1.03 to 1.67).LIMITATIONS: We have no information on past depressive episodes and cause of death.CONCLUSIONS: In contrast to reports in younger populations, depression does not appear to increase stroke risk among the old and very old, but continuous to be a risk factor for all-cause mortality.

KW - Age Distribution

KW - Aged

KW - Aged, 80 and over

KW - Cause of Death

KW - Depression

KW - Female

KW - Follow-Up Studies

KW - Germany

KW - Humans

KW - Incidence

KW - Male

KW - Models, Statistical

KW - Primary Health Care

KW - Prospective Studies

KW - Risk Factors

KW - Sex Distribution

KW - Stroke

U2 - 10.1016/j.jad.2013.02.020

DO - 10.1016/j.jad.2013.02.020

M3 - SCORING: Journal article

C2 - 23474092

VL - 150

SP - 63

EP - 69

JO - J AFFECT DISORDERS

JF - J AFFECT DISORDERS

SN - 0165-0327

IS - 1

ER -