Depression and quality of life in monogenic compared to idiopathic, early-onset Parkinson's disease.
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Depression and quality of life in monogenic compared to idiopathic, early-onset Parkinson's disease. / Kasten, Meike; Kertelge, Lena; Tadic, Vera; Brüggemann, Norbert; Schmidt, Alexander; van der Vegt, Joyce; Siebner, Hartwig; Buhmann, Carsten; Lencer, Rebekka; Kumar, Kishore R; Lohmann, Katja; Hagenah, Johann; Klein, Christine.
In: MOVEMENT DISORD, Vol. 27, No. 6, 6, 2012, p. 754-759.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Depression and quality of life in monogenic compared to idiopathic, early-onset Parkinson's disease.
AU - Kasten, Meike
AU - Kertelge, Lena
AU - Tadic, Vera
AU - Brüggemann, Norbert
AU - Schmidt, Alexander
AU - van der Vegt, Joyce
AU - Siebner, Hartwig
AU - Buhmann, Carsten
AU - Lencer, Rebekka
AU - Kumar, Kishore R
AU - Lohmann, Katja
AU - Hagenah, Johann
AU - Klein, Christine
PY - 2012
Y1 - 2012
N2 - Quality of life (QoL) is decreased in PD and is linked with depression and anxiety. However, little is known about QoL in monogenic PD. Subjects with mutations in PD genes were recruited from ongoing family and genetic studies (manifesting carriers, n = 23; nonmanifesting carriers, n = 19). For comparison purposes, we included patients with idiopathic PD (IPD; n = 128; early onset, n = 38; late onset, n = 90), healthy controls (n = 127), and data on depressive symptoms of 144 patients with major depression (treated controls). Depression affected 31% of early-onset PD cases, 21% of late-onset cases, and 44% of manifesting carriers of mutations in PD genes, but was rare in the nonmanifesting carriers (7%) and healthy controls (5%). Subjects with Parkinson-associated depression reported fewer feelings of guilt or self-doubt than treated controls, but the occurrence of suicidal ideation was associated with severity of depression only. Social phobia (P = 0.018) and agoraphobia (P = 0.059) were more common in manifesting carriers than in any other group. QoL was decreased in the Parkinson groups, particularly in the early-onset cases (P < 0.001), and QoL correlated with depression in all analyses. In our study, monogenic and IPD cases were comparable in QoL and depression characteristics. The QoL and, possibly, overall prognosis of all PD patients can be improved by appropriate attention and treatment for depression, sleep impairments, and anxiety, even if the treatment of the motor problems cannot be further optimized.
AB - Quality of life (QoL) is decreased in PD and is linked with depression and anxiety. However, little is known about QoL in monogenic PD. Subjects with mutations in PD genes were recruited from ongoing family and genetic studies (manifesting carriers, n = 23; nonmanifesting carriers, n = 19). For comparison purposes, we included patients with idiopathic PD (IPD; n = 128; early onset, n = 38; late onset, n = 90), healthy controls (n = 127), and data on depressive symptoms of 144 patients with major depression (treated controls). Depression affected 31% of early-onset PD cases, 21% of late-onset cases, and 44% of manifesting carriers of mutations in PD genes, but was rare in the nonmanifesting carriers (7%) and healthy controls (5%). Subjects with Parkinson-associated depression reported fewer feelings of guilt or self-doubt than treated controls, but the occurrence of suicidal ideation was associated with severity of depression only. Social phobia (P = 0.018) and agoraphobia (P = 0.059) were more common in manifesting carriers than in any other group. QoL was decreased in the Parkinson groups, particularly in the early-onset cases (P < 0.001), and QoL correlated with depression in all analyses. In our study, monogenic and IPD cases were comparable in QoL and depression characteristics. The QoL and, possibly, overall prognosis of all PD patients can be improved by appropriate attention and treatment for depression, sleep impairments, and anxiety, even if the treatment of the motor problems cannot be further optimized.
KW - Adult
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Questionnaires
KW - Severity of Illness Index
KW - Health Status
KW - Quality of Life/psychology
KW - Depression/complications/genetics/psychology
KW - Depressive Disorder/complications/genetics/psychology
KW - Parkinson Disease/complications/genetics/psychology
KW - Adult
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Questionnaires
KW - Severity of Illness Index
KW - Health Status
KW - Quality of Life/psychology
KW - Depression/complications/genetics/psychology
KW - Depressive Disorder/complications/genetics/psychology
KW - Parkinson Disease/complications/genetics/psychology
M3 - SCORING: Journal article
VL - 27
SP - 754
EP - 759
JO - MOVEMENT DISORD
JF - MOVEMENT DISORD
SN - 0885-3185
IS - 6
M1 - 6
ER -
