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Delayed release of brain natriuretic peptide to identify myocardial ischaemia

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Delayed release of brain natriuretic peptide to identify myocardial ischaemia. / Zürcher, Stephan; Honegger, Ursina; Wagener, Max; Lee, Gino; Stallone, Fabio; Marxer, Tanja; Puelacher, Christian; Schumacher, Carmela; Sou, Seoung Mann; Twerenbold, Raphael; Reichlin, Tobias; Hochgruber, Thomas; Tanglay, Yunus; Freese, Michael; Wild, Damian; Rentsch, Katharina; Osswald, Stefan; Zellweger, Michael; Mueller, Christian.

In: EUR J CLIN INVEST, Vol. 45, No. 11, 11.2015, p. 1175-1183.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Zürcher, S, Honegger, U, Wagener, M, Lee, G, Stallone, F, Marxer, T, Puelacher, C, Schumacher, C, Sou, SM, Twerenbold, R, Reichlin, T, Hochgruber, T, Tanglay, Y, Freese, M, Wild, D, Rentsch, K, Osswald, S, Zellweger, M & Mueller, C 2015, 'Delayed release of brain natriuretic peptide to identify myocardial ischaemia', EUR J CLIN INVEST, vol. 45, no. 11, pp. 1175-1183. https://doi.org/10.1111/eci.12535

APA

Zürcher, S., Honegger, U., Wagener, M., Lee, G., Stallone, F., Marxer, T., Puelacher, C., Schumacher, C., Sou, S. M., Twerenbold, R., Reichlin, T., Hochgruber, T., Tanglay, Y., Freese, M., Wild, D., Rentsch, K., Osswald, S., Zellweger, M., & Mueller, C. (2015). Delayed release of brain natriuretic peptide to identify myocardial ischaemia. EUR J CLIN INVEST, 45(11), 1175-1183. https://doi.org/10.1111/eci.12535

Vancouver

Zürcher S, Honegger U, Wagener M, Lee G, Stallone F, Marxer T et al. Delayed release of brain natriuretic peptide to identify myocardial ischaemia. EUR J CLIN INVEST. 2015 Nov;45(11):1175-1183. https://doi.org/10.1111/eci.12535

Bibtex

@article{b7f16393e9fa43f09085a8f1aa4daf82,
title = "Delayed release of brain natriuretic peptide to identify myocardial ischaemia",
abstract = "Background: A recent pilot study suggested that exercise-induced myocardial ischaemia may lead to a delayed release of cardiac biomarkers, so that later sampling, for example, at 4 h after exercise could be used for diagnostic purpose. Materials and methods: In an observational study, we enrolled 129 consecutive patients referred for evaluation of a suspected coronary artery disease by rest/stress myocardial perfusion single-photon emission computed tomography. The treating cardiologist used all available clinical information to quantify clinical judgment regarding the presence of myocardial ischaemia using a visual analogue scale twice: prior and after stress testing. BNP levels were determined in a blinded fashion at rest, at peak stress and 4 h after peak stress. The presence of myocardial ischaemia was adjudicated based on perfusion single-photon emission computed tomography and coronary angiography findings by an independent cardiologist. Results: Myocardial ischaemia was detected in 58 patients (45%). Patients with myocardial ischaemia had significantly higher BNP levels at all times, compared to patients without ischaemia: BNP rest (99 vs. 61 pg/mL P = 0·007), BNP stress (125 vs. 77 pg/mL P = 0·02) and BNP 4 h (114 vs. 71 pg/mL P = 0·018). Diagnostic accuracy as quantified by the area under the receiver operating characteristics curve (AUC) was moderate for all time points (AUC 0·64-0·66). The change in BNP between rest and 4 h did not provide added value, neither to the baseline BNP level nor to clinical judgment. Conclusion: In contrast to our hypothesis, myocardial ischaemia did not lead to a differential delayed release of BNP. Late sampling did not seem clinically useful.",
keywords = "Brain natriuretic peptide, Exercise electrocardiography, Myocardial ischaemia",
author = "Stephan Z{\"u}rcher and Ursina Honegger and Max Wagener and Gino Lee and Fabio Stallone and Tanja Marxer and Christian Puelacher and Carmela Schumacher and Sou, {Seoung Mann} and Raphael Twerenbold and Tobias Reichlin and Thomas Hochgruber and Yunus Tanglay and Michael Freese and Damian Wild and Katharina Rentsch and Stefan Osswald and Michael Zellweger and Christian Mueller",
note = "Publisher Copyright: {\textcopyright} 2015 Stichting European Society for Clinical Investigation Journal Foundation.",
year = "2015",
month = nov,
doi = "10.1111/eci.12535",
language = "English",
volume = "45",
pages = "1175--1183",
journal = "EUR J CLIN INVEST",
issn = "0014-2972",
publisher = "Wiley-Blackwell",
number = "11",

}

RIS

TY - JOUR

T1 - Delayed release of brain natriuretic peptide to identify myocardial ischaemia

AU - Zürcher, Stephan

AU - Honegger, Ursina

AU - Wagener, Max

AU - Lee, Gino

AU - Stallone, Fabio

AU - Marxer, Tanja

AU - Puelacher, Christian

AU - Schumacher, Carmela

AU - Sou, Seoung Mann

AU - Twerenbold, Raphael

AU - Reichlin, Tobias

AU - Hochgruber, Thomas

AU - Tanglay, Yunus

AU - Freese, Michael

AU - Wild, Damian

AU - Rentsch, Katharina

AU - Osswald, Stefan

AU - Zellweger, Michael

AU - Mueller, Christian

N1 - Publisher Copyright: © 2015 Stichting European Society for Clinical Investigation Journal Foundation.

PY - 2015/11

Y1 - 2015/11

N2 - Background: A recent pilot study suggested that exercise-induced myocardial ischaemia may lead to a delayed release of cardiac biomarkers, so that later sampling, for example, at 4 h after exercise could be used for diagnostic purpose. Materials and methods: In an observational study, we enrolled 129 consecutive patients referred for evaluation of a suspected coronary artery disease by rest/stress myocardial perfusion single-photon emission computed tomography. The treating cardiologist used all available clinical information to quantify clinical judgment regarding the presence of myocardial ischaemia using a visual analogue scale twice: prior and after stress testing. BNP levels were determined in a blinded fashion at rest, at peak stress and 4 h after peak stress. The presence of myocardial ischaemia was adjudicated based on perfusion single-photon emission computed tomography and coronary angiography findings by an independent cardiologist. Results: Myocardial ischaemia was detected in 58 patients (45%). Patients with myocardial ischaemia had significantly higher BNP levels at all times, compared to patients without ischaemia: BNP rest (99 vs. 61 pg/mL P = 0·007), BNP stress (125 vs. 77 pg/mL P = 0·02) and BNP 4 h (114 vs. 71 pg/mL P = 0·018). Diagnostic accuracy as quantified by the area under the receiver operating characteristics curve (AUC) was moderate for all time points (AUC 0·64-0·66). The change in BNP between rest and 4 h did not provide added value, neither to the baseline BNP level nor to clinical judgment. Conclusion: In contrast to our hypothesis, myocardial ischaemia did not lead to a differential delayed release of BNP. Late sampling did not seem clinically useful.

AB - Background: A recent pilot study suggested that exercise-induced myocardial ischaemia may lead to a delayed release of cardiac biomarkers, so that later sampling, for example, at 4 h after exercise could be used for diagnostic purpose. Materials and methods: In an observational study, we enrolled 129 consecutive patients referred for evaluation of a suspected coronary artery disease by rest/stress myocardial perfusion single-photon emission computed tomography. The treating cardiologist used all available clinical information to quantify clinical judgment regarding the presence of myocardial ischaemia using a visual analogue scale twice: prior and after stress testing. BNP levels were determined in a blinded fashion at rest, at peak stress and 4 h after peak stress. The presence of myocardial ischaemia was adjudicated based on perfusion single-photon emission computed tomography and coronary angiography findings by an independent cardiologist. Results: Myocardial ischaemia was detected in 58 patients (45%). Patients with myocardial ischaemia had significantly higher BNP levels at all times, compared to patients without ischaemia: BNP rest (99 vs. 61 pg/mL P = 0·007), BNP stress (125 vs. 77 pg/mL P = 0·02) and BNP 4 h (114 vs. 71 pg/mL P = 0·018). Diagnostic accuracy as quantified by the area under the receiver operating characteristics curve (AUC) was moderate for all time points (AUC 0·64-0·66). The change in BNP between rest and 4 h did not provide added value, neither to the baseline BNP level nor to clinical judgment. Conclusion: In contrast to our hypothesis, myocardial ischaemia did not lead to a differential delayed release of BNP. Late sampling did not seem clinically useful.

KW - Brain natriuretic peptide

KW - Exercise electrocardiography

KW - Myocardial ischaemia

UR - http://www.scopus.com/inward/record.url?scp=84945444903&partnerID=8YFLogxK

U2 - 10.1111/eci.12535

DO - 10.1111/eci.12535

M3 - SCORING: Journal article

C2 - 26331403

AN - SCOPUS:84945444903

VL - 45

SP - 1175

EP - 1183

JO - EUR J CLIN INVEST

JF - EUR J CLIN INVEST

SN - 0014-2972

IS - 11

ER -