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Delayed Hemolysis After Treatment With Parenteral Artesunate in African Children With Severe Malaria-A Double-center Prospective Study

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Delayed Hemolysis After Treatment With Parenteral Artesunate in African Children With Severe Malaria-A Double-center Prospective Study. / Rolling, Thierry; Agbenyega, Tsiri; Issifou, Saadou; Adegnika, Ayola Akim; Sylverken, Justice; Spahlinger, Dorothee; Ansong, Daniel; Löhr, Sascha J Z; Burchard, Gerd-Dieter; May, Jürgen; Mordmüller, Benjamin; Krishna, Sanjeev; Kremsner, Peter G; Cramer, Jakob P.

In: J INFECT DIS, Vol. 209, No. 12, 15.06.2014, p. 1921-8.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Rolling, T, Agbenyega, T, Issifou, S, Adegnika, AA, Sylverken, J, Spahlinger, D, Ansong, D, Löhr, SJZ, Burchard, G-D, May, J, Mordmüller, B, Krishna, S, Kremsner, PG & Cramer, JP 2014, 'Delayed Hemolysis After Treatment With Parenteral Artesunate in African Children With Severe Malaria-A Double-center Prospective Study', J INFECT DIS, vol. 209, no. 12, pp. 1921-8. https://doi.org/10.1093/infdis/jit841

APA

Rolling, T., Agbenyega, T., Issifou, S., Adegnika, A. A., Sylverken, J., Spahlinger, D., Ansong, D., Löhr, S. J. Z., Burchard, G-D., May, J., Mordmüller, B., Krishna, S., Kremsner, P. G., & Cramer, J. P. (2014). Delayed Hemolysis After Treatment With Parenteral Artesunate in African Children With Severe Malaria-A Double-center Prospective Study. J INFECT DIS, 209(12), 1921-8. https://doi.org/10.1093/infdis/jit841

Vancouver

Rolling T, Agbenyega T, Issifou S, Adegnika AA, Sylverken J, Spahlinger D et al. Delayed Hemolysis After Treatment With Parenteral Artesunate in African Children With Severe Malaria-A Double-center Prospective Study. J INFECT DIS. 2014 Jun 15;209(12):1921-8. https://doi.org/10.1093/infdis/jit841

Bibtex

@article{7f622ccca0554f178ebd24ddad701022,
title = "Delayed Hemolysis After Treatment With Parenteral Artesunate in African Children With Severe Malaria-A Double-center Prospective Study",
abstract = "BACKGROUND: Parenteral artesunate is recommended as first-line therapy for severe malaria. While its efficacy is firmly established, data on safety are still incomplete. Delayed hemolysis has been described in hyperparasitemic nonimmune travelers, but it is unknown if African children are equally at risk.METHODS: Children aged 6 to 120 months with severe malaria were followed up after treatment with parenteral artesunate in Lambar{\'e}n{\'e}, Gabon, and Kumasi, Ghana. The primary outcome was incidence of delayed hemolysis on day 14.RESULTS: In total, 72 children contributed complete data sets necessary for primary outcome assessment. Delayed hemolysis was detected in 5 children (7%), with 1 child reaching a nadir in hemoglobin of 2.8 g/dL. Patients with delayed hemolysis had higher parasite counts on admission (geometric mean parasite densities (GMPD) 306 968/µL vs 92 642/µL, P = .028) and were younger (median age: 24 months vs 43 months, P = .046) than the rest of the cohort. No correlation with sickle cell trait or glucose-6-phosphate-dehydrogenase deficiency was observed.CONCLUSIONS: Delayed hemolysis is a frequent and relevant complication in hyperparasitemic African children treated with parenteral artesunate for severe malaria. Physicians should be aware of this complication and consider prolonged follow-up.CLINICAL TRIALS REGISTRATION: Pan-African Clinical Trials Registry: PACTR201102000277177 (www.pactr.org).",
author = "Thierry Rolling and Tsiri Agbenyega and Saadou Issifou and Adegnika, {Ayola Akim} and Justice Sylverken and Dorothee Spahlinger and Daniel Ansong and L{\"o}hr, {Sascha J Z} and Gerd-Dieter Burchard and J{\"u}rgen May and Benjamin Mordm{\"u}ller and Sanjeev Krishna and Kremsner, {Peter G} and Cramer, {Jakob P}",
note = "{\textcopyright} The Author 2013. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.",
year = "2014",
month = jun,
day = "15",
doi = "10.1093/infdis/jit841",
language = "English",
volume = "209",
pages = "1921--8",
journal = "J INFECT DIS",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "12",

}

RIS

TY - JOUR

T1 - Delayed Hemolysis After Treatment With Parenteral Artesunate in African Children With Severe Malaria-A Double-center Prospective Study

AU - Rolling, Thierry

AU - Agbenyega, Tsiri

AU - Issifou, Saadou

AU - Adegnika, Ayola Akim

AU - Sylverken, Justice

AU - Spahlinger, Dorothee

AU - Ansong, Daniel

AU - Löhr, Sascha J Z

AU - Burchard, Gerd-Dieter

AU - May, Jürgen

AU - Mordmüller, Benjamin

AU - Krishna, Sanjeev

AU - Kremsner, Peter G

AU - Cramer, Jakob P

N1 - © The Author 2013. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

PY - 2014/6/15

Y1 - 2014/6/15

N2 - BACKGROUND: Parenteral artesunate is recommended as first-line therapy for severe malaria. While its efficacy is firmly established, data on safety are still incomplete. Delayed hemolysis has been described in hyperparasitemic nonimmune travelers, but it is unknown if African children are equally at risk.METHODS: Children aged 6 to 120 months with severe malaria were followed up after treatment with parenteral artesunate in Lambaréné, Gabon, and Kumasi, Ghana. The primary outcome was incidence of delayed hemolysis on day 14.RESULTS: In total, 72 children contributed complete data sets necessary for primary outcome assessment. Delayed hemolysis was detected in 5 children (7%), with 1 child reaching a nadir in hemoglobin of 2.8 g/dL. Patients with delayed hemolysis had higher parasite counts on admission (geometric mean parasite densities (GMPD) 306 968/µL vs 92 642/µL, P = .028) and were younger (median age: 24 months vs 43 months, P = .046) than the rest of the cohort. No correlation with sickle cell trait or glucose-6-phosphate-dehydrogenase deficiency was observed.CONCLUSIONS: Delayed hemolysis is a frequent and relevant complication in hyperparasitemic African children treated with parenteral artesunate for severe malaria. Physicians should be aware of this complication and consider prolonged follow-up.CLINICAL TRIALS REGISTRATION: Pan-African Clinical Trials Registry: PACTR201102000277177 (www.pactr.org).

AB - BACKGROUND: Parenteral artesunate is recommended as first-line therapy for severe malaria. While its efficacy is firmly established, data on safety are still incomplete. Delayed hemolysis has been described in hyperparasitemic nonimmune travelers, but it is unknown if African children are equally at risk.METHODS: Children aged 6 to 120 months with severe malaria were followed up after treatment with parenteral artesunate in Lambaréné, Gabon, and Kumasi, Ghana. The primary outcome was incidence of delayed hemolysis on day 14.RESULTS: In total, 72 children contributed complete data sets necessary for primary outcome assessment. Delayed hemolysis was detected in 5 children (7%), with 1 child reaching a nadir in hemoglobin of 2.8 g/dL. Patients with delayed hemolysis had higher parasite counts on admission (geometric mean parasite densities (GMPD) 306 968/µL vs 92 642/µL, P = .028) and were younger (median age: 24 months vs 43 months, P = .046) than the rest of the cohort. No correlation with sickle cell trait or glucose-6-phosphate-dehydrogenase deficiency was observed.CONCLUSIONS: Delayed hemolysis is a frequent and relevant complication in hyperparasitemic African children treated with parenteral artesunate for severe malaria. Physicians should be aware of this complication and consider prolonged follow-up.CLINICAL TRIALS REGISTRATION: Pan-African Clinical Trials Registry: PACTR201102000277177 (www.pactr.org).

U2 - 10.1093/infdis/jit841

DO - 10.1093/infdis/jit841

M3 - SCORING: Journal article

C2 - 24376273

VL - 209

SP - 1921

EP - 1928

JO - J INFECT DIS

JF - J INFECT DIS

SN - 0022-1899

IS - 12

ER -