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DEGRO practical guideline for central nervous system radiation necrosis part 2

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DEGRO practical guideline for central nervous system radiation necrosis part 2 : treatment. / Bernhardt, Denise; König, Laila; Grosu, Anca-L; Rieken, Stefan; Krieg, Sandro M; Wick, Wolfgang; Wiestler, Benedikt; Schmidt-Graf, Friederike; Sahm, Felix; Gempt, Jens; Meyer, Bernhard; Krause, Bernd J; Petersen, Cordula; Fietkau, Rainer; Thomas, Michael; Giordano, Frank; Wittig-Sauerwein, Andrea; Debus, Jürgen; Tabatabai, Ghazaleh; Hau, Peter; Steinbach, Joachim; Combs, Stephanie E; Expert Panel of the German Society of Radiation Oncology (DEGRO).

In: STRAHLENTHER ONKOL, Vol. 198, No. 11, 11.2022, p. 971-980.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Bernhardt, D, König, L, Grosu, A-L, Rieken, S, Krieg, SM, Wick, W, Wiestler, B, Schmidt-Graf, F, Sahm, F, Gempt, J, Meyer, B, Krause, BJ, Petersen, C, Fietkau, R, Thomas, M, Giordano, F, Wittig-Sauerwein, A, Debus, J, Tabatabai, G, Hau, P, Steinbach, J, Combs, SE & Expert Panel of the German Society of Radiation Oncology (DEGRO) 2022, 'DEGRO practical guideline for central nervous system radiation necrosis part 2: treatment', STRAHLENTHER ONKOL, vol. 198, no. 11, pp. 971-980. https://doi.org/10.1007/s00066-022-01973-8

APA

Bernhardt, D., König, L., Grosu, A-L., Rieken, S., Krieg, S. M., Wick, W., Wiestler, B., Schmidt-Graf, F., Sahm, F., Gempt, J., Meyer, B., Krause, B. J., Petersen, C., Fietkau, R., Thomas, M., Giordano, F., Wittig-Sauerwein, A., Debus, J., Tabatabai, G., ... Expert Panel of the German Society of Radiation Oncology (DEGRO) (2022). DEGRO practical guideline for central nervous system radiation necrosis part 2: treatment. STRAHLENTHER ONKOL, 198(11), 971-980. https://doi.org/10.1007/s00066-022-01973-8

Vancouver

Bernhardt D, König L, Grosu A-L, Rieken S, Krieg SM, Wick W et al. DEGRO practical guideline for central nervous system radiation necrosis part 2: treatment. STRAHLENTHER ONKOL. 2022 Nov;198(11):971-980. https://doi.org/10.1007/s00066-022-01973-8

Bibtex

@article{60aff48a642e442cab4fa738e0866b27,
title = "DEGRO practical guideline for central nervous system radiation necrosis part 2: treatment",
abstract = "PURPOSE: The Working Group for Neurooncology of the German Society for Radiation Oncology (DEGRO; AG NRO) in cooperation with members of the Neurooncological Working Group of the German Cancer Society (DKG-NOA) aimed to define a practical guideline for the diagnosis and treatment of radiation-induced necrosis (RN) of the central nervous system (CNS).METHODS: Panel members of the DEGRO working group invited experts, participated in a series of conferences, supplemented their clinical experience, performed a literature review, and formulated recommendations for medical treatment of RN, including bevacizumab, in clinical routine.CONCLUSION: Diagnosis and treatment of RN requires multidisciplinary structures of care and defined processes. Diagnosis has to be made on an interdisciplinary level with the joint knowledge of a neuroradiologist, radiation oncologist, neurosurgeon, neuropathologist, and neurooncologist. If the diagnosis of blood-brain barrier disruptions (BBD) or RN is likely, treatment should be initiated depending on the symptoms, location, and dynamic of the lesion. Multiple treatment options are available (such as observation, surgery, steroids, and bevacizumab) and the optimal approach should be discussed in an interdisciplinary setting. In this practice guideline, we offer detailed treatment strategies for various scenarios.",
keywords = "Humans, Radiosurgery, Bevacizumab/therapeutic use, Radiation Injuries/etiology, Central Nervous System, Necrosis",
author = "Denise Bernhardt and Laila K{\"o}nig and Anca-L Grosu and Stefan Rieken and Krieg, {Sandro M} and Wolfgang Wick and Benedikt Wiestler and Friederike Schmidt-Graf and Felix Sahm and Jens Gempt and Bernhard Meyer and Krause, {Bernd J} and Cordula Petersen and Rainer Fietkau and Michael Thomas and Frank Giordano and Andrea Wittig-Sauerwein and J{\"u}rgen Debus and Ghazaleh Tabatabai and Peter Hau and Joachim Steinbach and Combs, {Stephanie E} and {Expert Panel of the German Society of Radiation Oncology (DEGRO)}",
note = "{\textcopyright} 2022. The Author(s).",
year = "2022",
month = nov,
doi = "10.1007/s00066-022-01973-8",
language = "English",
volume = "198",
pages = "971--980",
journal = "STRAHLENTHER ONKOL",
issn = "0179-7158",
publisher = "Urban und Vogel",
number = "11",

}

RIS

TY - JOUR

T1 - DEGRO practical guideline for central nervous system radiation necrosis part 2

T2 - treatment

AU - Bernhardt, Denise

AU - König, Laila

AU - Grosu, Anca-L

AU - Rieken, Stefan

AU - Krieg, Sandro M

AU - Wick, Wolfgang

AU - Wiestler, Benedikt

AU - Schmidt-Graf, Friederike

AU - Sahm, Felix

AU - Gempt, Jens

AU - Meyer, Bernhard

AU - Krause, Bernd J

AU - Petersen, Cordula

AU - Fietkau, Rainer

AU - Thomas, Michael

AU - Giordano, Frank

AU - Wittig-Sauerwein, Andrea

AU - Debus, Jürgen

AU - Tabatabai, Ghazaleh

AU - Hau, Peter

AU - Steinbach, Joachim

AU - Combs, Stephanie E

AU - Expert Panel of the German Society of Radiation Oncology (DEGRO)

N1 - © 2022. The Author(s).

PY - 2022/11

Y1 - 2022/11

N2 - PURPOSE: The Working Group for Neurooncology of the German Society for Radiation Oncology (DEGRO; AG NRO) in cooperation with members of the Neurooncological Working Group of the German Cancer Society (DKG-NOA) aimed to define a practical guideline for the diagnosis and treatment of radiation-induced necrosis (RN) of the central nervous system (CNS).METHODS: Panel members of the DEGRO working group invited experts, participated in a series of conferences, supplemented their clinical experience, performed a literature review, and formulated recommendations for medical treatment of RN, including bevacizumab, in clinical routine.CONCLUSION: Diagnosis and treatment of RN requires multidisciplinary structures of care and defined processes. Diagnosis has to be made on an interdisciplinary level with the joint knowledge of a neuroradiologist, radiation oncologist, neurosurgeon, neuropathologist, and neurooncologist. If the diagnosis of blood-brain barrier disruptions (BBD) or RN is likely, treatment should be initiated depending on the symptoms, location, and dynamic of the lesion. Multiple treatment options are available (such as observation, surgery, steroids, and bevacizumab) and the optimal approach should be discussed in an interdisciplinary setting. In this practice guideline, we offer detailed treatment strategies for various scenarios.

AB - PURPOSE: The Working Group for Neurooncology of the German Society for Radiation Oncology (DEGRO; AG NRO) in cooperation with members of the Neurooncological Working Group of the German Cancer Society (DKG-NOA) aimed to define a practical guideline for the diagnosis and treatment of radiation-induced necrosis (RN) of the central nervous system (CNS).METHODS: Panel members of the DEGRO working group invited experts, participated in a series of conferences, supplemented their clinical experience, performed a literature review, and formulated recommendations for medical treatment of RN, including bevacizumab, in clinical routine.CONCLUSION: Diagnosis and treatment of RN requires multidisciplinary structures of care and defined processes. Diagnosis has to be made on an interdisciplinary level with the joint knowledge of a neuroradiologist, radiation oncologist, neurosurgeon, neuropathologist, and neurooncologist. If the diagnosis of blood-brain barrier disruptions (BBD) or RN is likely, treatment should be initiated depending on the symptoms, location, and dynamic of the lesion. Multiple treatment options are available (such as observation, surgery, steroids, and bevacizumab) and the optimal approach should be discussed in an interdisciplinary setting. In this practice guideline, we offer detailed treatment strategies for various scenarios.

KW - Humans

KW - Radiosurgery

KW - Bevacizumab/therapeutic use

KW - Radiation Injuries/etiology

KW - Central Nervous System

KW - Necrosis

U2 - 10.1007/s00066-022-01973-8

DO - 10.1007/s00066-022-01973-8

M3 - SCORING: Review article

C2 - 36038670

VL - 198

SP - 971

EP - 980

JO - STRAHLENTHER ONKOL

JF - STRAHLENTHER ONKOL

SN - 0179-7158

IS - 11

ER -