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DEGRO practical guideline for central nervous system radiation necrosis part 1: classification and a multistep approach for diagnosis

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DEGRO practical guideline for central nervous system radiation necrosis part 1: classification and a multistep approach for diagnosis. / Bernhardt, Denise; König, Laila; Grosu, Anca; Wiestler, Benedikt; Rieken, Stefan; Wick, Wolfgang; Gempt, Jens; Krieg, Sandro M; Schmidt-Graf, Friederike; Sahm, Felix; Meyer, Bernhard; Krause, Bernd J; Petersen, Cordula; Fietkau, Rainer; Thomas, Michael; Giordano, Frank; Wittig-Sauerwein, Andrea; Debus, Jürgen; Tabatabai, Ghazaleh; Hau, Peter; Steinbach, Joachim; Combs, Stephanie E; Expert Panel of the German Society of Radiation Oncology (DEGRO).

In: STRAHLENTHER ONKOL, Vol. 198, No. 10, 10.2022, p. 873-883.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Bernhardt, D, König, L, Grosu, A, Wiestler, B, Rieken, S, Wick, W, Gempt, J, Krieg, SM, Schmidt-Graf, F, Sahm, F, Meyer, B, Krause, BJ, Petersen, C, Fietkau, R, Thomas, M, Giordano, F, Wittig-Sauerwein, A, Debus, J, Tabatabai, G, Hau, P, Steinbach, J, Combs, SE & Expert Panel of the German Society of Radiation Oncology (DEGRO) 2022, 'DEGRO practical guideline for central nervous system radiation necrosis part 1: classification and a multistep approach for diagnosis', STRAHLENTHER ONKOL, vol. 198, no. 10, pp. 873-883. https://doi.org/10.1007/s00066-022-01994-3

APA

Bernhardt, D., König, L., Grosu, A., Wiestler, B., Rieken, S., Wick, W., Gempt, J., Krieg, S. M., Schmidt-Graf, F., Sahm, F., Meyer, B., Krause, B. J., Petersen, C., Fietkau, R., Thomas, M., Giordano, F., Wittig-Sauerwein, A., Debus, J., Tabatabai, G., ... Expert Panel of the German Society of Radiation Oncology (DEGRO) (2022). DEGRO practical guideline for central nervous system radiation necrosis part 1: classification and a multistep approach for diagnosis. STRAHLENTHER ONKOL, 198(10), 873-883. https://doi.org/10.1007/s00066-022-01994-3

Vancouver

Bernhardt D, König L, Grosu A, Wiestler B, Rieken S, Wick W et al. DEGRO practical guideline for central nervous system radiation necrosis part 1: classification and a multistep approach for diagnosis. STRAHLENTHER ONKOL. 2022 Oct;198(10):873-883. https://doi.org/10.1007/s00066-022-01994-3

Bibtex

@article{335bed6f1ffe4b42b81ae75d1744d593,
title = "DEGRO practical guideline for central nervous system radiation necrosis part 1: classification and a multistep approach for diagnosis",
abstract = "PURPOSE: The Working Group for Neuro-Oncology of the German Society for Radiation Oncology in cooperation with members of the Neuro-Oncology Working Group of the German Cancer Society aimed to define a practical guideline for the diagnosis and treatment of radiation-induced necrosis (RN) of the central nervous system (CNS).METHODS: Panel members of the DEGRO working group invited experts, participated in a series of conferences, supplemented their clinical experience, performed a literature review, and formulated recommendations for medical treatment of RN including bevacizumab in clinical routine.CONCLUSION: Diagnosis and treatment of RN requires multidisciplinary structures of care and defined processes. Diagnosis has to be made on an interdisciplinary level with the joint knowledge of a neuroradiologist, radiation oncologist, neurosurgeon, neuropathologist, and neuro-oncologist. A multistep approach as an opportunity to review as many characteristics as possible to improve diagnostic confidence is recommended. Additional information about radiotherapy (RT) techniques is crucial for the diagnosis of RN. Misdiagnosis of untreated and progressive RN can lead to severe neurological deficits. In this practice guideline, we propose a detailed nomenclature of treatment-related changes and a multistep approach for their diagnosis.",
keywords = "Bevacizumab, Central Nervous System, Humans, Necrosis, Radiation Injuries/diagnosis, Radiation Oncology",
author = "Denise Bernhardt and Laila K{\"o}nig and Anca Grosu and Benedikt Wiestler and Stefan Rieken and Wolfgang Wick and Jens Gempt and Krieg, {Sandro M} and Friederike Schmidt-Graf and Felix Sahm and Bernhard Meyer and Krause, {Bernd J} and Cordula Petersen and Rainer Fietkau and Michael Thomas and Frank Giordano and Andrea Wittig-Sauerwein and J{\"u}rgen Debus and Ghazaleh Tabatabai and Peter Hau and Joachim Steinbach and Combs, {Stephanie E} and {Expert Panel of the German Society of Radiation Oncology (DEGRO)}",
note = "{\textcopyright} 2022. The Author(s).",
year = "2022",
month = oct,
doi = "10.1007/s00066-022-01994-3",
language = "English",
volume = "198",
pages = "873--883",
journal = "STRAHLENTHER ONKOL",
issn = "0179-7158",
publisher = "Urban und Vogel",
number = "10",

}

RIS

TY - JOUR

T1 - DEGRO practical guideline for central nervous system radiation necrosis part 1: classification and a multistep approach for diagnosis

AU - Bernhardt, Denise

AU - König, Laila

AU - Grosu, Anca

AU - Wiestler, Benedikt

AU - Rieken, Stefan

AU - Wick, Wolfgang

AU - Gempt, Jens

AU - Krieg, Sandro M

AU - Schmidt-Graf, Friederike

AU - Sahm, Felix

AU - Meyer, Bernhard

AU - Krause, Bernd J

AU - Petersen, Cordula

AU - Fietkau, Rainer

AU - Thomas, Michael

AU - Giordano, Frank

AU - Wittig-Sauerwein, Andrea

AU - Debus, Jürgen

AU - Tabatabai, Ghazaleh

AU - Hau, Peter

AU - Steinbach, Joachim

AU - Combs, Stephanie E

AU - Expert Panel of the German Society of Radiation Oncology (DEGRO)

N1 - © 2022. The Author(s).

PY - 2022/10

Y1 - 2022/10

N2 - PURPOSE: The Working Group for Neuro-Oncology of the German Society for Radiation Oncology in cooperation with members of the Neuro-Oncology Working Group of the German Cancer Society aimed to define a practical guideline for the diagnosis and treatment of radiation-induced necrosis (RN) of the central nervous system (CNS).METHODS: Panel members of the DEGRO working group invited experts, participated in a series of conferences, supplemented their clinical experience, performed a literature review, and formulated recommendations for medical treatment of RN including bevacizumab in clinical routine.CONCLUSION: Diagnosis and treatment of RN requires multidisciplinary structures of care and defined processes. Diagnosis has to be made on an interdisciplinary level with the joint knowledge of a neuroradiologist, radiation oncologist, neurosurgeon, neuropathologist, and neuro-oncologist. A multistep approach as an opportunity to review as many characteristics as possible to improve diagnostic confidence is recommended. Additional information about radiotherapy (RT) techniques is crucial for the diagnosis of RN. Misdiagnosis of untreated and progressive RN can lead to severe neurological deficits. In this practice guideline, we propose a detailed nomenclature of treatment-related changes and a multistep approach for their diagnosis.

AB - PURPOSE: The Working Group for Neuro-Oncology of the German Society for Radiation Oncology in cooperation with members of the Neuro-Oncology Working Group of the German Cancer Society aimed to define a practical guideline for the diagnosis and treatment of radiation-induced necrosis (RN) of the central nervous system (CNS).METHODS: Panel members of the DEGRO working group invited experts, participated in a series of conferences, supplemented their clinical experience, performed a literature review, and formulated recommendations for medical treatment of RN including bevacizumab in clinical routine.CONCLUSION: Diagnosis and treatment of RN requires multidisciplinary structures of care and defined processes. Diagnosis has to be made on an interdisciplinary level with the joint knowledge of a neuroradiologist, radiation oncologist, neurosurgeon, neuropathologist, and neuro-oncologist. A multistep approach as an opportunity to review as many characteristics as possible to improve diagnostic confidence is recommended. Additional information about radiotherapy (RT) techniques is crucial for the diagnosis of RN. Misdiagnosis of untreated and progressive RN can lead to severe neurological deficits. In this practice guideline, we propose a detailed nomenclature of treatment-related changes and a multistep approach for their diagnosis.

KW - Bevacizumab

KW - Central Nervous System

KW - Humans

KW - Necrosis

KW - Radiation Injuries/diagnosis

KW - Radiation Oncology

U2 - 10.1007/s00066-022-01994-3

DO - 10.1007/s00066-022-01994-3

M3 - SCORING: Review article

C2 - 36038669

VL - 198

SP - 873

EP - 883

JO - STRAHLENTHER ONKOL

JF - STRAHLENTHER ONKOL

SN - 0179-7158

IS - 10

ER -