Defining the Optimal Dose of Stereotactic Radiosurgery for Treating Cerebral Metastases in Elderly Patients

Dirk Rades; Markus Dahlke; Liesa Dziggel; Stefan Janssen; Amira Bajrovic; Ngo Thuy Trang; Mai Trong Khoa; Steven E Schild

Defining the Optimal Dose of Stereotactic Radiosurgery for Treating Cerebral Metastases in Elderly Patients

Standard

Defining the Optimal Dose of Stereotactic Radiosurgery for Treating Cerebral Metastases in Elderly Patients. / Rades, Dirk; Dahlke, Markus; Dziggel, Liesa; Janssen, Stefan; Bajrovic, Amira; Trang, Ngo Thuy; Khoa, Mai Trong; Schild, Steven E.

In: ANTICANCER RES, Vol. 35, No. 10, 10.2015, p. 5701-4.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Rades, D, Dahlke, M, Dziggel, L, Janssen, S, Bajrovic, A, Trang, NT, Khoa, MT & Schild, SE 2015, 'Defining the Optimal Dose of Stereotactic Radiosurgery for Treating Cerebral Metastases in Elderly Patients', ANTICANCER RES, vol. 35, no. 10, pp. 5701-4.

APA

Rades, D., Dahlke, M., Dziggel, L., Janssen, S., Bajrovic, A., Trang, N. T., Khoa, M. T., & Schild, S. E. (2015). Defining the Optimal Dose of Stereotactic Radiosurgery for Treating Cerebral Metastases in Elderly Patients. ANTICANCER RES, 35(10), 5701-4.

Vancouver

Rades D, Dahlke M, Dziggel L, Janssen S, Bajrovic A, Trang NT et al. Defining the Optimal Dose of Stereotactic Radiosurgery for Treating Cerebral Metastases in Elderly Patients. ANTICANCER RES. 2015 Oct;35(10):5701-4.

Bibtex

@article{cdd6844d299a447ea37ef59e073f4555,

title = "Defining the Optimal Dose of Stereotactic Radiosurgery for Treating Cerebral Metastases in Elderly Patients",

abstract = "BACKGROUND/AIM: In oncology, elderly people are a separate group of patients requiring special consideration. This applies to the treatment of cerebral metastases as well. The present study focused on elderly patients receiving stereotactic radiosurgery (SRS) for few cerebral lesions.PATIENTS AND METHODS: In 95 patients aged ≥65 years, two SRS doses, 16-18 Gy (n=44) and 20 Gy (n=51), were compared regarding outcomes of SRS.RESULTS: The overall intracerebral control rates at 12 months were 30% after 16-18 Gy and 45% after 20 Gy (p=0.53). Twelve-month rates of freedom from new intracerebral lesions were 41% and 52%, respectively (p=0.63). Twelve-month local control rates of the irradiated lesions were 55% and 81%, respectively (p=0.069). Overall survival rates at 12 months were 29% and 31%, respectively (p=0.67).CONCLUSION: SRS with 16-18 Gy was not significantly inferior to SRS with 20 Gy in elderly patients with few cerebral metastases.",

keywords = "Aged, Brain Neoplasms, Dose Fractionation, Female, Follow-Up Studies, Humans, Male, Neoplasm Staging, Neoplasms, Prognosis, Radiosurgery, Retrospective Studies, Survival Rate",

author = "Dirk Rades and Markus Dahlke and Liesa Dziggel and Stefan Janssen and Amira Bajrovic and Trang, {Ngo Thuy} and Khoa, {Mai Trong} and Schild, {Steven E}",

year = "2015",

month = oct,

language = "English",

volume = "35",

pages = "5701--4",

journal = "ANTICANCER RES",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

number = "10",

}

RIS

TY - JOUR

T1 - Defining the Optimal Dose of Stereotactic Radiosurgery for Treating Cerebral Metastases in Elderly Patients

AU - Rades, Dirk

AU - Dahlke, Markus

AU - Dziggel, Liesa

AU - Janssen, Stefan

AU - Bajrovic, Amira

AU - Trang, Ngo Thuy

AU - Khoa, Mai Trong

AU - Schild, Steven E

PY - 2015/10

Y1 - 2015/10

N2 - BACKGROUND/AIM: In oncology, elderly people are a separate group of patients requiring special consideration. This applies to the treatment of cerebral metastases as well. The present study focused on elderly patients receiving stereotactic radiosurgery (SRS) for few cerebral lesions.PATIENTS AND METHODS: In 95 patients aged ≥65 years, two SRS doses, 16-18 Gy (n=44) and 20 Gy (n=51), were compared regarding outcomes of SRS.RESULTS: The overall intracerebral control rates at 12 months were 30% after 16-18 Gy and 45% after 20 Gy (p=0.53). Twelve-month rates of freedom from new intracerebral lesions were 41% and 52%, respectively (p=0.63). Twelve-month local control rates of the irradiated lesions were 55% and 81%, respectively (p=0.069). Overall survival rates at 12 months were 29% and 31%, respectively (p=0.67).CONCLUSION: SRS with 16-18 Gy was not significantly inferior to SRS with 20 Gy in elderly patients with few cerebral metastases.

AB - BACKGROUND/AIM: In oncology, elderly people are a separate group of patients requiring special consideration. This applies to the treatment of cerebral metastases as well. The present study focused on elderly patients receiving stereotactic radiosurgery (SRS) for few cerebral lesions.PATIENTS AND METHODS: In 95 patients aged ≥65 years, two SRS doses, 16-18 Gy (n=44) and 20 Gy (n=51), were compared regarding outcomes of SRS.RESULTS: The overall intracerebral control rates at 12 months were 30% after 16-18 Gy and 45% after 20 Gy (p=0.53). Twelve-month rates of freedom from new intracerebral lesions were 41% and 52%, respectively (p=0.63). Twelve-month local control rates of the irradiated lesions were 55% and 81%, respectively (p=0.069). Overall survival rates at 12 months were 29% and 31%, respectively (p=0.67).CONCLUSION: SRS with 16-18 Gy was not significantly inferior to SRS with 20 Gy in elderly patients with few cerebral metastases.

KW - Aged

KW - Brain Neoplasms

KW - Dose Fractionation

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Male

KW - Neoplasm Staging

KW - Neoplasms

KW - Prognosis

KW - Radiosurgery

KW - Retrospective Studies

KW - Survival Rate

M3 - SCORING: Journal article

C2 - 26408746

VL - 35

SP - 5701

EP - 5704

JO - ANTICANCER RES

JF - ANTICANCER RES

SN - 0250-7005

IS - 10

ER -