Defäkationsverhalten nach koloanaler Rekonstruktion im Schweinemodell
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Defäkationsverhalten nach koloanaler Rekonstruktion im Schweinemodell. / Debus, E S; Sailer, M; Thiede, A.
In: ZBL CHIR, Vol. 126 Suppl 1, 2001, p. 67-70.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Defäkationsverhalten nach koloanaler Rekonstruktion im Schweinemodell
AU - Debus, E S
AU - Sailer, M
AU - Thiede, A
PY - 2001
Y1 - 2001
N2 - UNLABELLED: Defecation properties after coloanal reconstruction in the pig model.OBJECTIVE: Functional aspects after low anterior resection are of major interest. While patients with straight coloanal anastomoses may suffer from disabling stool frequency and incontinence, evacuation difficulties can be a problem in coloanal pouch anastomoses. The aim of the study was to investigate functional results by establishing a standardized defecation protocol after low anterior resection of the rectum in the pig model.METHOD: 24 adult Göttinger mini pigs were studied. They were randomly assigned to three groups: 8 animals served as control animals (group 1), the remaining 16 underwent low anterior resection with small colon-J-pouch (4-5 cm) reconstruction (n = 8) and large pouch design of 8-9 cm length (n = 8). The animals were investigated after 12 weeks postoperatively. Defecation properties we studied using a Ceruletide-induced defecography (0.3 microgram kgKG) with a 100 ml barium sulfate bolus, placed just above the anastomosis.RESULTS: Evacuation was significantly impaired in the large pouch (45 min.). However, the small pouches evacuated completely after 14 min. which was comparable to the unoperated controls (17.3 min.).CONCLUSION: Ceruletide-induced defecation reveals reproducible results in pigs. Evacualtion properties are highly depending upon the coloanal reconstruction. A small colon-J-pouch design reveals nearly physiologic results 3 months after surgery.
AB - UNLABELLED: Defecation properties after coloanal reconstruction in the pig model.OBJECTIVE: Functional aspects after low anterior resection are of major interest. While patients with straight coloanal anastomoses may suffer from disabling stool frequency and incontinence, evacuation difficulties can be a problem in coloanal pouch anastomoses. The aim of the study was to investigate functional results by establishing a standardized defecation protocol after low anterior resection of the rectum in the pig model.METHOD: 24 adult Göttinger mini pigs were studied. They were randomly assigned to three groups: 8 animals served as control animals (group 1), the remaining 16 underwent low anterior resection with small colon-J-pouch (4-5 cm) reconstruction (n = 8) and large pouch design of 8-9 cm length (n = 8). The animals were investigated after 12 weeks postoperatively. Defecation properties we studied using a Ceruletide-induced defecography (0.3 microgram kgKG) with a 100 ml barium sulfate bolus, placed just above the anastomosis.RESULTS: Evacuation was significantly impaired in the large pouch (45 min.). However, the small pouches evacuated completely after 14 min. which was comparable to the unoperated controls (17.3 min.).CONCLUSION: Ceruletide-induced defecation reveals reproducible results in pigs. Evacualtion properties are highly depending upon the coloanal reconstruction. A small colon-J-pouch design reveals nearly physiologic results 3 months after surgery.
KW - Anal Canal/surgery
KW - Anastomosis, Surgical
KW - Animals
KW - Ceruletide
KW - Colon/surgery
KW - Defecation
KW - Follow-Up Studies
KW - Proctocolectomy, Restorative/methods
KW - Swine
KW - Swine, Miniature/surgery
KW - Time Factors
U2 - 10.1055/s-2001-19204
DO - 10.1055/s-2001-19204
M3 - SCORING: Zeitschriftenaufsatz
C2 - 11819177
VL - 126 Suppl 1
SP - 67
EP - 70
JO - ZBL CHIR
JF - ZBL CHIR
SN - 0044-409X
ER -
