Deep brain stimulation via segmented leads in the subthalamic nucleus in Parkinson's disease-impact on axial symptoms
Related Research units
Abstract
Target: To compare omnidirectional and directed STN-DBS (anterior, postero-medial or postero-lateral) in PD patients.
Methods: The primary outcomes of the prospective, randomised, double-blind, clinical trial were acute changes of spatial-temporal gait parameters at different walking conditions, i.e. preferred speed, maximal speed and during adapted gait. These parameters were captured by the GAITRITEÒ system with different stimulation modes, i.e. ring-mode stimulation, stimulation of single segments (anterior, postero-medial, postero-lateral) and with the stimulator turned off on a single day in the medication off-state. Secondary
outcomes were changes of freezing of gait (Ziegler Course), motor- symptoms (MDS-UPDRS motor part III, with focus on axial PIGD subitems), static and dynamic balance abilities (Berg Balance score— short-version).
Results: Preliminary results determine the effect of DBS in the STN on spatial gait parameters, freezing of gait, balance abilities and motor symptoms. The difference of conventional ring-mode DBS compared to each single segment (anterior, postero-medial, postero-lateral) seems to vary between outcome measurements with prefer- able findings for stimulation in the antero-medial direction. Conclusion: Preliminary results support the positive impact of STN- DBS on axial symptoms in PD patients. It is proposed that uniseg-mental stimulation might take advantage of the somatotopic organisation of STN sub territories for further improvement of gait and postural stability.
Bibliographical data
Translated title of the contribution | THS durch segmentale Elektroden im STN bei Personen mit Morbus Parkinson—Auswirkungen auf axiale Symptome |
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Original language | English |
Article number | Vol. 126. No. 5. |
ISSN | 0300-9564 |
Publication status | Published - 01.05.2019 |
Event | Deutscher Kongress für Parkinson und Bewegungsstörungen - Düsseldorf, Germany Duration: 07.03.2019 → 09.03.2019 Conference number: 11 |