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Deep brain stimulation of the nucleus ventralis intermedius: a thalamic site of graviceptive modulation

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Deep brain stimulation of the nucleus ventralis intermedius: a thalamic site of graviceptive modulation. / Baier, Bernhard; Vogt, Thomas; Rhode, Franziska; Cuvenhaus, Hannah; Conrad, Julian; Dieterich, Marianne.

In: BRAIN STRUCT FUNCT, 09.12.2015.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Baier, B, Vogt, T, Rhode, F, Cuvenhaus, H, Conrad, J & Dieterich, M 2015, 'Deep brain stimulation of the nucleus ventralis intermedius: a thalamic site of graviceptive modulation', BRAIN STRUCT FUNCT. https://doi.org/10.1007/s00429-015-1157-x

APA

Baier, B., Vogt, T., Rhode, F., Cuvenhaus, H., Conrad, J., & Dieterich, M. (2015). Deep brain stimulation of the nucleus ventralis intermedius: a thalamic site of graviceptive modulation. BRAIN STRUCT FUNCT. https://doi.org/10.1007/s00429-015-1157-x

Vancouver

Baier B, Vogt T, Rhode F, Cuvenhaus H, Conrad J, Dieterich M. Deep brain stimulation of the nucleus ventralis intermedius: a thalamic site of graviceptive modulation. BRAIN STRUCT FUNCT. 2015 Dec 9. https://doi.org/10.1007/s00429-015-1157-x

Bibtex

@article{a8d3539d70a946cd931b98bdaf14668f,
title = "Deep brain stimulation of the nucleus ventralis intermedius: a thalamic site of graviceptive modulation",
abstract = "Based on animal studies, it has been shown that the nucleus ventralis intermedius (VIM) of the thalamus plays an important role within the vestibular system. A few human studies support the vestibular role of the VIM. In this study, we aimed to test the hypothesis whether changing the stimulation status in patients with unilateral deep brain stimulation in the VIM causally modulates the vestibular system, i.e., the graviceptive vertical perception. We tested six tremor patients for tilt of subjective visual vertical (SVV) with unilateral DBS in the VIM (mean age 67 years; mean time since electrode implantation 55 months). The mean tilt of the patients during the stimulator {"}on{"} condition was 1.4° to the contraversive side [standard deviation (SD) ± 0.4°] whereas during the {"}off{"} period a mean contraversive tilt of 4.4° (SD ± 3.0°) was obtained (p = 0.02). Thus, we were able to show that otolith-dominated graviceptive vertical perception can be directly modulated by changing the status of DBS VIM stimulation, indicating that the VIM is directly involved in (contraversive) vertical perception and its thalamic pathways.",
author = "Bernhard Baier and Thomas Vogt and Franziska Rhode and Hannah Cuvenhaus and Julian Conrad and Marianne Dieterich",
year = "2015",
month = dec,
day = "9",
doi = "10.1007/s00429-015-1157-x",
language = "English",
journal = "BRAIN STRUCT FUNCT",
issn = "1863-2653",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - Deep brain stimulation of the nucleus ventralis intermedius: a thalamic site of graviceptive modulation

AU - Baier, Bernhard

AU - Vogt, Thomas

AU - Rhode, Franziska

AU - Cuvenhaus, Hannah

AU - Conrad, Julian

AU - Dieterich, Marianne

PY - 2015/12/9

Y1 - 2015/12/9

N2 - Based on animal studies, it has been shown that the nucleus ventralis intermedius (VIM) of the thalamus plays an important role within the vestibular system. A few human studies support the vestibular role of the VIM. In this study, we aimed to test the hypothesis whether changing the stimulation status in patients with unilateral deep brain stimulation in the VIM causally modulates the vestibular system, i.e., the graviceptive vertical perception. We tested six tremor patients for tilt of subjective visual vertical (SVV) with unilateral DBS in the VIM (mean age 67 years; mean time since electrode implantation 55 months). The mean tilt of the patients during the stimulator "on" condition was 1.4° to the contraversive side [standard deviation (SD) ± 0.4°] whereas during the "off" period a mean contraversive tilt of 4.4° (SD ± 3.0°) was obtained (p = 0.02). Thus, we were able to show that otolith-dominated graviceptive vertical perception can be directly modulated by changing the status of DBS VIM stimulation, indicating that the VIM is directly involved in (contraversive) vertical perception and its thalamic pathways.

AB - Based on animal studies, it has been shown that the nucleus ventralis intermedius (VIM) of the thalamus plays an important role within the vestibular system. A few human studies support the vestibular role of the VIM. In this study, we aimed to test the hypothesis whether changing the stimulation status in patients with unilateral deep brain stimulation in the VIM causally modulates the vestibular system, i.e., the graviceptive vertical perception. We tested six tremor patients for tilt of subjective visual vertical (SVV) with unilateral DBS in the VIM (mean age 67 years; mean time since electrode implantation 55 months). The mean tilt of the patients during the stimulator "on" condition was 1.4° to the contraversive side [standard deviation (SD) ± 0.4°] whereas during the "off" period a mean contraversive tilt of 4.4° (SD ± 3.0°) was obtained (p = 0.02). Thus, we were able to show that otolith-dominated graviceptive vertical perception can be directly modulated by changing the status of DBS VIM stimulation, indicating that the VIM is directly involved in (contraversive) vertical perception and its thalamic pathways.

U2 - 10.1007/s00429-015-1157-x

DO - 10.1007/s00429-015-1157-x

M3 - SCORING: Journal article

C2 - 26650047

JO - BRAIN STRUCT FUNCT

JF - BRAIN STRUCT FUNCT

SN - 1863-2653

ER -