Research ExplorerPublicationsDecreased mebrofenin uptake in patients with non-colorectal ...

Decreased mebrofenin uptake in patients with non-colorectal liver tumors requiring liver volume augmentation-a single-center analysis

Standard

Decreased mebrofenin uptake in patients with non-colorectal liver tumors requiring liver volume augmentation-a single-center analysis. / Fard-Aghaie, M H; Stern, L; Ghadban, T; Apostolova, I; Lehnert, W; Klutmann, S; Hackert, T; Izbicki, J R; Li, J; von Kroge, P H; Heumann, A.

In: LANGENBECK ARCH SURG, Vol. 409, No. 1, 11.03.2024, p. 92.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Fard-Aghaie, MH, Stern, L, Ghadban, T, Apostolova, I, Lehnert, W, Klutmann, S, Hackert, T, Izbicki, JR, Li, J, von Kroge, PH & Heumann, A 2024, 'Decreased mebrofenin uptake in patients with non-colorectal liver tumors requiring liver volume augmentation-a single-center analysis', LANGENBECK ARCH SURG, vol. 409, no. 1, pp. 92. https://doi.org/10.1007/s00423-024-03280-5

APA

Fard-Aghaie, M. H., Stern, L., Ghadban, T., Apostolova, I., Lehnert, W., Klutmann, S., Hackert, T., Izbicki, J. R., Li, J., von Kroge, P. H., & Heumann, A. (2024). Decreased mebrofenin uptake in patients with non-colorectal liver tumors requiring liver volume augmentation-a single-center analysis. LANGENBECK ARCH SURG, 409(1), 92. https://doi.org/10.1007/s00423-024-03280-5

Vancouver

Fard-Aghaie MH, Stern L, Ghadban T, Apostolova I, Lehnert W, Klutmann S et al. Decreased mebrofenin uptake in patients with non-colorectal liver tumors requiring liver volume augmentation-a single-center analysis. LANGENBECK ARCH SURG. 2024 Mar 11;409(1):92. https://doi.org/10.1007/s00423-024-03280-5

Bibtex

@article{2bc678c7f4934e8590412c7ad37cef90,
title = "Decreased mebrofenin uptake in patients with non-colorectal liver tumors requiring liver volume augmentation-a single-center analysis",
abstract = "BACKGROUND: Posthepatectomy liver failure (PHLF) remains a life-threatening complication after hepatectomy. To reduce PHLF, a preoperative assessment of liver function is indispensable. For this purpose, 99mTc-mebrofenin hepatobiliary scintigraphy with SPECT (MSPECT) can be used. The aim of the current study was to evaluate the predictive value of MSPECT for PHLF in patients with non-colorectal liver tumors (NCRLT) compared to patients with colorectal liver metastasis (CRLM) undergoing extended liver resection.METHODS: We included all patients undergoing extended liver resections via two-stage procedures between January 2019 and December 2021 at the University Medical Center Hamburg-Eppendorf, Germany. All patients received a preoperative MSPECT.RESULTS: Twenty patients were included. In every fourth patient, PHLF was observed. Four patients had PHLF grade C. There were no differences between patients with CRLM and NCRLT regarding PHLF rate and future liver remnant (FLR) volume. Patients with CRLM had higher mebrofenin uptake in the FLR compared to those with NCRLT (2.49%/min/m2 vs. 1.51%/min/m2; p = 0.004).CONCLUSION: Mebrofenin uptake in patients with NCRLT was lower compared to those patients with CRLM. However, there was no difference in the PHLF rate and FLR volume. Cut-off values for the mebrofenin uptake might need adjustments for different surgical indications, surgical procedures, and underlying diseases.",
keywords = "Humans, Radiopharmaceuticals, Liver/diagnostic imaging, Liver Neoplasms/diagnostic imaging, Hepatectomy/adverse effects, Liver Failure/etiology, Colorectal Neoplasms/diagnostic imaging, Retrospective Studies, Postoperative Complications, Aniline Compounds, Glycine",
author = "Fard-Aghaie, {M H} and L Stern and T Ghadban and I Apostolova and W Lehnert and S Klutmann and T Hackert and Izbicki, {J R} and J Li and {von Kroge}, {P H} and A Heumann",
note = "{\textcopyright} 2024. The Author(s).",
year = "2024",
month = mar,
day = "11",
doi = "10.1007/s00423-024-03280-5",
language = "English",
volume = "409",
pages = "92",
journal = "LANGENBECK ARCH SURG",
issn = "1435-2443",
publisher = "Springer",
number = "1",

}

RIS

TY - JOUR

T1 - Decreased mebrofenin uptake in patients with non-colorectal liver tumors requiring liver volume augmentation-a single-center analysis

AU - Fard-Aghaie, M H

AU - Stern, L

AU - Ghadban, T

AU - Apostolova, I

AU - Lehnert, W

AU - Klutmann, S

AU - Hackert, T

AU - Izbicki, J R

AU - Li, J

AU - von Kroge, P H

AU - Heumann, A

N1 - © 2024. The Author(s).

PY - 2024/3/11

Y1 - 2024/3/11

N2 - BACKGROUND: Posthepatectomy liver failure (PHLF) remains a life-threatening complication after hepatectomy. To reduce PHLF, a preoperative assessment of liver function is indispensable. For this purpose, 99mTc-mebrofenin hepatobiliary scintigraphy with SPECT (MSPECT) can be used. The aim of the current study was to evaluate the predictive value of MSPECT for PHLF in patients with non-colorectal liver tumors (NCRLT) compared to patients with colorectal liver metastasis (CRLM) undergoing extended liver resection.METHODS: We included all patients undergoing extended liver resections via two-stage procedures between January 2019 and December 2021 at the University Medical Center Hamburg-Eppendorf, Germany. All patients received a preoperative MSPECT.RESULTS: Twenty patients were included. In every fourth patient, PHLF was observed. Four patients had PHLF grade C. There were no differences between patients with CRLM and NCRLT regarding PHLF rate and future liver remnant (FLR) volume. Patients with CRLM had higher mebrofenin uptake in the FLR compared to those with NCRLT (2.49%/min/m2 vs. 1.51%/min/m2; p = 0.004).CONCLUSION: Mebrofenin uptake in patients with NCRLT was lower compared to those patients with CRLM. However, there was no difference in the PHLF rate and FLR volume. Cut-off values for the mebrofenin uptake might need adjustments for different surgical indications, surgical procedures, and underlying diseases.

AB - BACKGROUND: Posthepatectomy liver failure (PHLF) remains a life-threatening complication after hepatectomy. To reduce PHLF, a preoperative assessment of liver function is indispensable. For this purpose, 99mTc-mebrofenin hepatobiliary scintigraphy with SPECT (MSPECT) can be used. The aim of the current study was to evaluate the predictive value of MSPECT for PHLF in patients with non-colorectal liver tumors (NCRLT) compared to patients with colorectal liver metastasis (CRLM) undergoing extended liver resection.METHODS: We included all patients undergoing extended liver resections via two-stage procedures between January 2019 and December 2021 at the University Medical Center Hamburg-Eppendorf, Germany. All patients received a preoperative MSPECT.RESULTS: Twenty patients were included. In every fourth patient, PHLF was observed. Four patients had PHLF grade C. There were no differences between patients with CRLM and NCRLT regarding PHLF rate and future liver remnant (FLR) volume. Patients with CRLM had higher mebrofenin uptake in the FLR compared to those with NCRLT (2.49%/min/m2 vs. 1.51%/min/m2; p = 0.004).CONCLUSION: Mebrofenin uptake in patients with NCRLT was lower compared to those patients with CRLM. However, there was no difference in the PHLF rate and FLR volume. Cut-off values for the mebrofenin uptake might need adjustments for different surgical indications, surgical procedures, and underlying diseases.

KW - Humans

KW - Radiopharmaceuticals

KW - Liver/diagnostic imaging

KW - Liver Neoplasms/diagnostic imaging

KW - Hepatectomy/adverse effects

KW - Liver Failure/etiology

KW - Colorectal Neoplasms/diagnostic imaging

KW - Retrospective Studies

KW - Postoperative Complications

KW - Aniline Compounds

KW - Glycine

U2 - 10.1007/s00423-024-03280-5

DO - 10.1007/s00423-024-03280-5

M3 - SCORING: Journal article

C2 - 38467934

VL - 409

SP - 92

JO - LANGENBECK ARCH SURG

JF - LANGENBECK ARCH SURG

SN - 1435-2443

IS - 1

ER -