Decreased interferon-gamma response in respiratory syncytial virus compared to other respiratory viral infections in infants.
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Decreased interferon-gamma response in respiratory syncytial virus compared to other respiratory viral infections in infants. / Aberle, Jens; Aberle, S W; Rebhandl, W; Pracher, E; Kundi, M; Popow-Kraupp, T.
In: CLIN EXP IMMUNOL, Vol. 137, No. 1, 1, 2004, p. 146-150.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Decreased interferon-gamma response in respiratory syncytial virus compared to other respiratory viral infections in infants.
AU - Aberle, Jens
AU - Aberle, S W
AU - Rebhandl, W
AU - Pracher, E
AU - Kundi, M
AU - Popow-Kraupp, T
PY - 2004
Y1 - 2004
N2 - An inappropriate interferon-gamma response has been implicated in the pathogenesis of severe respiratory syncytial virus (RSV) lower respiratory tract illness (LRTI). To assess whether this is unique for RSV primary LRTI compared to a first non-RSV LRTI, intracellular interferon-gamma was determined by flow cytometry in peripheral blood mononuclear cells from 32 infants with a primary RSV infection, 28 with a first non-RSV LRTI due to adenoviral, parainfluenzaviral and rhinoviral infection and 13 healthy infants. Interferon-gamma responses were increased significantly during adenoviral, parainfluenzaviral and the majority of the rhinoviral infections, but remained low during RSV and severe rhinoviral infection. Low interferon-gamma responses were associated with a more severe clinical course of LRTI. This indicates that depending on the nature of the viral pathogen, respiratory virus infections in infants differ significantly with regard to the quantity of the interferon-gamma production and that this may contribute to the clinical course of the disease.
AB - An inappropriate interferon-gamma response has been implicated in the pathogenesis of severe respiratory syncytial virus (RSV) lower respiratory tract illness (LRTI). To assess whether this is unique for RSV primary LRTI compared to a first non-RSV LRTI, intracellular interferon-gamma was determined by flow cytometry in peripheral blood mononuclear cells from 32 infants with a primary RSV infection, 28 with a first non-RSV LRTI due to adenoviral, parainfluenzaviral and rhinoviral infection and 13 healthy infants. Interferon-gamma responses were increased significantly during adenoviral, parainfluenzaviral and the majority of the rhinoviral infections, but remained low during RSV and severe rhinoviral infection. Low interferon-gamma responses were associated with a more severe clinical course of LRTI. This indicates that depending on the nature of the viral pathogen, respiratory virus infections in infants differ significantly with regard to the quantity of the interferon-gamma production and that this may contribute to the clinical course of the disease.
M3 - SCORING: Zeitschriftenaufsatz
VL - 137
SP - 146
EP - 150
JO - CLIN EXP IMMUNOL
JF - CLIN EXP IMMUNOL
SN - 0009-9104
IS - 1
M1 - 1
ER -
