Decreased active von Willebrand factor level owing to shear stress in aortic stenosis patients.
Standard
Decreased active von Willebrand factor level owing to shear stress in aortic stenosis patients. / Hollestelle, M J; Loots, C M; Squizzato, A; Renné, Thomas; Bouma, B J; de Groot, P G; Lenting, P J; Meijers, J C M; Gerdes, V E A.
In: J THROMB HAEMOST, Vol. 9, No. 5, 5, 2011, p. 953-958.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Decreased active von Willebrand factor level owing to shear stress in aortic stenosis patients.
AU - Hollestelle, M J
AU - Loots, C M
AU - Squizzato, A
AU - Renné, Thomas
AU - Bouma, B J
AU - de Groot, P G
AU - Lenting, P J
AU - Meijers, J C M
AU - Gerdes, V E A
PY - 2011
Y1 - 2011
N2 - Aortic stenosis patients often show bleeding complications. Previously, a prolonged platelet function analyzer (PFA-100) closure time was observed with plasma of severe aortic stenosis patients. To elucidate a possible role of circulating preactivated von Willebrand factor (VWF), we determined the level of VWF in its active, platelet-binding conformation in plasma of patients with aortic stenosis.
AB - Aortic stenosis patients often show bleeding complications. Previously, a prolonged platelet function analyzer (PFA-100) closure time was observed with plasma of severe aortic stenosis patients. To elucidate a possible role of circulating preactivated von Willebrand factor (VWF), we determined the level of VWF in its active, platelet-binding conformation in plasma of patients with aortic stenosis.
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Questionnaires
KW - Stress, Mechanical
KW - ADAM Proteins/blood
KW - Aortic Valve Stenosis/blood/pathology
KW - Hemorrhage
KW - Hemostasis
KW - Peptides/chemistry
KW - Platelet Function Tests
KW - Shear Strength
KW - von Willebrand Factor/biosynthesis
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Questionnaires
KW - Stress, Mechanical
KW - ADAM Proteins/blood
KW - Aortic Valve Stenosis/blood/pathology
KW - Hemorrhage
KW - Hemostasis
KW - Peptides/chemistry
KW - Platelet Function Tests
KW - Shear Strength
KW - von Willebrand Factor/biosynthesis
M3 - SCORING: Journal article
VL - 9
SP - 953
EP - 958
JO - J THROMB HAEMOST
JF - J THROMB HAEMOST
SN - 1538-7933
IS - 5
M1 - 5
ER -