Decidual immune cells: Guardians of human pregnancies

Maria Emilia Solano

doi:10.1016/j.bpobgyn.2019.05.009

Decidual immune cells: Guardians of human pregnancies

Standard

Decidual immune cells: Guardians of human pregnancies. / Solano, Maria Emilia.

In: BEST PRACT RES CL OB, Vol. 60, 10.2019, p. 3-16.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Solano, ME 2019, 'Decidual immune cells: Guardians of human pregnancies', BEST PRACT RES CL OB, vol. 60, pp. 3-16. https://doi.org/10.1016/j.bpobgyn.2019.05.009

APA

Solano, M. E. (2019). Decidual immune cells: Guardians of human pregnancies. BEST PRACT RES CL OB, 60, 3-16. https://doi.org/10.1016/j.bpobgyn.2019.05.009

Vancouver

Solano ME. Decidual immune cells: Guardians of human pregnancies. BEST PRACT RES CL OB. 2019 Oct;60:3-16. https://doi.org/10.1016/j.bpobgyn.2019.05.009

Bibtex

@article{94d4fd02f1224735be51f1521f62072c,

title = "Decidual immune cells: Guardians of human pregnancies",

abstract = "During human pregnancy, trophoblast cells, the main cellular component of the placenta, invade deeply into uterine blood vessels and the modified endometrium (decidua). Hence, the maternal immune system must adapt to it. A successful pregnancy requires the tolerance of genetically different (allogenic) cells while the mother's immune competence is maintained. This tolerance is ensured through multiple overlapping and occasionally redundant innate and adaptive immune mechanisms. The present article aims to provide a broad overview on uterine immune cell components and the phenotypical and functional changes that they experience during pregnancy. Particularly, we seek to highlight very recent findings in functional adaptations to pregnancy in immune cell populations encountered in the decidua. These adaptations not only ensure tolerance to allogenic trophoblast cells but also promote optimal placental and fetal growth, simultaneously endeavoring to maintain immune surveillance to provide defense against infections.",

author = "Solano, {Maria Emilia}",

year = "2019",

month = oct,

doi = "10.1016/j.bpobgyn.2019.05.009",

language = "English",

volume = "60",

pages = "3--16",

journal = "BEST PRACT RES CL OB",

issn = "1521-6934",

publisher = "Bailliere Tindall Ltd",

}

RIS

TY - JOUR

T1 - Decidual immune cells: Guardians of human pregnancies

AU - Solano, Maria Emilia

PY - 2019/10

Y1 - 2019/10

N2 - During human pregnancy, trophoblast cells, the main cellular component of the placenta, invade deeply into uterine blood vessels and the modified endometrium (decidua). Hence, the maternal immune system must adapt to it. A successful pregnancy requires the tolerance of genetically different (allogenic) cells while the mother's immune competence is maintained. This tolerance is ensured through multiple overlapping and occasionally redundant innate and adaptive immune mechanisms. The present article aims to provide a broad overview on uterine immune cell components and the phenotypical and functional changes that they experience during pregnancy. Particularly, we seek to highlight very recent findings in functional adaptations to pregnancy in immune cell populations encountered in the decidua. These adaptations not only ensure tolerance to allogenic trophoblast cells but also promote optimal placental and fetal growth, simultaneously endeavoring to maintain immune surveillance to provide defense against infections.

AB - During human pregnancy, trophoblast cells, the main cellular component of the placenta, invade deeply into uterine blood vessels and the modified endometrium (decidua). Hence, the maternal immune system must adapt to it. A successful pregnancy requires the tolerance of genetically different (allogenic) cells while the mother's immune competence is maintained. This tolerance is ensured through multiple overlapping and occasionally redundant innate and adaptive immune mechanisms. The present article aims to provide a broad overview on uterine immune cell components and the phenotypical and functional changes that they experience during pregnancy. Particularly, we seek to highlight very recent findings in functional adaptations to pregnancy in immune cell populations encountered in the decidua. These adaptations not only ensure tolerance to allogenic trophoblast cells but also promote optimal placental and fetal growth, simultaneously endeavoring to maintain immune surveillance to provide defense against infections.

U2 - 10.1016/j.bpobgyn.2019.05.009

DO - 10.1016/j.bpobgyn.2019.05.009

M3 - SCORING: Review article

C2 - 31285174

VL - 60

SP - 3

EP - 16

JO - BEST PRACT RES CL OB

JF - BEST PRACT RES CL OB

SN - 1521-6934

ER -