The risk-need-responsivity (RNR) model is proven to be an effective model in the treatment of people who became delinquent, in order to reduce the risk of reoffending. To ensure that individual treatment is planned with maximum efficacy, not only risk factors but also specific responsivity factors (SRF) should be thoroughly assessed. The specific responsivity principle calls for client-oriented flexibility in implementing treatment and managing individual treatment barriers. Nevertheless, the principle is often criticized for being under-researched and rarely considered in practice. This review aims to support clinicians in identifying a variety of SRF of their clients in order to adapt treatment accordingly or to address SRF directly. Once again, this paper underscores the importance but also the complexity of operationalizing SRF and managing them in treatment and research.