Das Darmmikrobiom in der Pathogenese und Therapie chronisch-entzündlicher Darmerkrankungen
Related Research units
Abstract
Inflammatory bowel diseases (IBD) are systemic diseases that mainly manifest in the gastrointestinal tract. Due to chronically impaired intestinal homeostasis, they often require permanent and in some cases systemic therapy. The exact causes of IBD are largely unknown. It is postulated that these complex diseases arise in genetically susceptible individuals through a misdirected immune response, promoted by barrier defects, environmental toxins, and the gut microbiome. In this regard, the importance of the microbiome and its pathogenic changes (dysbiosis) in the pathogenesis of IBD is increasingly coming into focus. This review article presents the current state of research on the role of the microbiome in the development of IBD. Therapeutic approaches aimed at correcting intestinal dysbiosis are also discussed.
Bibliographical data
Translated title of the contribution | Role of the gut microbiome in the pathogenesis and treatment of inflammatory bowel diseases |
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Original language | German |
ISSN | 2731-7080 |
DOIs | |
Publication status | Published - 10.2022 |
Comment Deanary
© 2022. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.
PubMed | 36044059 |
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