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Cytotoxic T Cell-Derived Granzyme B Is Increased in Severe Plasmodium Falciparum Malaria

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Cytotoxic T Cell-Derived Granzyme B Is Increased in Severe Plasmodium Falciparum Malaria. / Kaminski, Lea-Christina; Riehn, Mathias; Abel, Annemieke; Steeg, Christiane; Yar, Denis Dekugmen; Addai-Mensah, Otchere; Aminkiah, Francis; Owusu Dabo, Ellis; Jacobs, Thomas; Mackroth, Maria Sophia.

In: FRONT IMMUNOL, Vol. 10, 2019, p. 2917.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kaminski, L-C, Riehn, M, Abel, A, Steeg, C, Yar, DD, Addai-Mensah, O, Aminkiah, F, Owusu Dabo, E, Jacobs, T & Mackroth, MS 2019, 'Cytotoxic T Cell-Derived Granzyme B Is Increased in Severe Plasmodium Falciparum Malaria', FRONT IMMUNOL, vol. 10, pp. 2917. https://doi.org/10.3389/fimmu.2019.02917

APA

Kaminski, L-C., Riehn, M., Abel, A., Steeg, C., Yar, D. D., Addai-Mensah, O., Aminkiah, F., Owusu Dabo, E., Jacobs, T., & Mackroth, M. S. (2019). Cytotoxic T Cell-Derived Granzyme B Is Increased in Severe Plasmodium Falciparum Malaria. FRONT IMMUNOL, 10, 2917. https://doi.org/10.3389/fimmu.2019.02917

Vancouver

Kaminski L-C, Riehn M, Abel A, Steeg C, Yar DD, Addai-Mensah O et al. Cytotoxic T Cell-Derived Granzyme B Is Increased in Severe Plasmodium Falciparum Malaria. FRONT IMMUNOL. 2019;10:2917. https://doi.org/10.3389/fimmu.2019.02917

Bibtex

@article{c4b7b91b8ca647a1b4507c7433f59100,
title = "Cytotoxic T Cell-Derived Granzyme B Is Increased in Severe Plasmodium Falciparum Malaria",
abstract = "In Plasmodium falciparum malaria, CD8+ T cells play a double-edged role. Liver-stage specific CD8+ T cells can confer protection, as has been shown in several vaccine studies. Blood-stage specific CD8+ T cells, on the other hand, contribute to the development of cerebral malaria in murine models of malaria. The role of CD8+ T cells in humans during the blood-stage of P. falciparum remains unclear. As part of a cross-sectional malaria study in Ghana, granzyme B levels and CD8+ T cells phenotypes were compared in the peripheral blood of children with complicated malaria, uncomplicated malaria, afebrile but asymptomatically infected children and non-infected children. Granzyme B levels in the plasma were significantly higher in children with febrile malaria than in afebrile children. CD8+ T cells were the main T cell subset expressing granzyme B. The proportion of granzyme B+ CD8+ T cells was significantly higher in children with complicated malaria than in uncomplicated malaria, whereas the activation marker CD38 on CD8+ T cells showed similar expression levels. This suggests a pathogenic role of cytotoxic CD8+ T cells in the development of malaria complications in humans.",
author = "Lea-Christina Kaminski and Mathias Riehn and Annemieke Abel and Christiane Steeg and Yar, {Denis Dekugmen} and Otchere Addai-Mensah and Francis Aminkiah and {Owusu Dabo}, Ellis and Thomas Jacobs and Mackroth, {Maria Sophia}",
note = "Copyright {\textcopyright} 2019 Kaminski, Riehn, Abel, Steeg, Yar, Addai-Mensah, Aminkiah, Owusu Dabo, Jacobs and Mackroth.",
year = "2019",
doi = "10.3389/fimmu.2019.02917",
language = "English",
volume = "10",
pages = "2917",
journal = "FRONT IMMUNOL",
issn = "1664-3224",
publisher = "Lausanne : Frontiers Research Foundation",

}

RIS

TY - JOUR

T1 - Cytotoxic T Cell-Derived Granzyme B Is Increased in Severe Plasmodium Falciparum Malaria

AU - Kaminski, Lea-Christina

AU - Riehn, Mathias

AU - Abel, Annemieke

AU - Steeg, Christiane

AU - Yar, Denis Dekugmen

AU - Addai-Mensah, Otchere

AU - Aminkiah, Francis

AU - Owusu Dabo, Ellis

AU - Jacobs, Thomas

AU - Mackroth, Maria Sophia

N1 - Copyright © 2019 Kaminski, Riehn, Abel, Steeg, Yar, Addai-Mensah, Aminkiah, Owusu Dabo, Jacobs and Mackroth.

PY - 2019

Y1 - 2019

N2 - In Plasmodium falciparum malaria, CD8+ T cells play a double-edged role. Liver-stage specific CD8+ T cells can confer protection, as has been shown in several vaccine studies. Blood-stage specific CD8+ T cells, on the other hand, contribute to the development of cerebral malaria in murine models of malaria. The role of CD8+ T cells in humans during the blood-stage of P. falciparum remains unclear. As part of a cross-sectional malaria study in Ghana, granzyme B levels and CD8+ T cells phenotypes were compared in the peripheral blood of children with complicated malaria, uncomplicated malaria, afebrile but asymptomatically infected children and non-infected children. Granzyme B levels in the plasma were significantly higher in children with febrile malaria than in afebrile children. CD8+ T cells were the main T cell subset expressing granzyme B. The proportion of granzyme B+ CD8+ T cells was significantly higher in children with complicated malaria than in uncomplicated malaria, whereas the activation marker CD38 on CD8+ T cells showed similar expression levels. This suggests a pathogenic role of cytotoxic CD8+ T cells in the development of malaria complications in humans.

AB - In Plasmodium falciparum malaria, CD8+ T cells play a double-edged role. Liver-stage specific CD8+ T cells can confer protection, as has been shown in several vaccine studies. Blood-stage specific CD8+ T cells, on the other hand, contribute to the development of cerebral malaria in murine models of malaria. The role of CD8+ T cells in humans during the blood-stage of P. falciparum remains unclear. As part of a cross-sectional malaria study in Ghana, granzyme B levels and CD8+ T cells phenotypes were compared in the peripheral blood of children with complicated malaria, uncomplicated malaria, afebrile but asymptomatically infected children and non-infected children. Granzyme B levels in the plasma were significantly higher in children with febrile malaria than in afebrile children. CD8+ T cells were the main T cell subset expressing granzyme B. The proportion of granzyme B+ CD8+ T cells was significantly higher in children with complicated malaria than in uncomplicated malaria, whereas the activation marker CD38 on CD8+ T cells showed similar expression levels. This suggests a pathogenic role of cytotoxic CD8+ T cells in the development of malaria complications in humans.

U2 - 10.3389/fimmu.2019.02917

DO - 10.3389/fimmu.2019.02917

M3 - SCORING: Journal article

C2 - 31921176

VL - 10

SP - 2917

JO - FRONT IMMUNOL

JF - FRONT IMMUNOL

SN - 1664-3224

ER -