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Cytomegalovirus (CMV) Pneumonitis: Cell Tropism, Inflammation, and Immunity

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Cytomegalovirus (CMV) Pneumonitis: Cell Tropism, Inflammation, and Immunity. / Fonseca Brito, Luís; Brune, Wolfram; Stahl, Felix R.

In: INT J MOL SCI, Vol. 20, No. 16, 08.08.2019, p. 3865.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Fonseca Brito, L, Brune, W & Stahl, FR 2019, 'Cytomegalovirus (CMV) Pneumonitis: Cell Tropism, Inflammation, and Immunity', INT J MOL SCI, vol. 20, no. 16, pp. 3865. https://doi.org/10.3390/ijms20163865

APA

Fonseca Brito, L., Brune, W., & Stahl, F. R. (2019). Cytomegalovirus (CMV) Pneumonitis: Cell Tropism, Inflammation, and Immunity. INT J MOL SCI, 20(16), 3865. https://doi.org/10.3390/ijms20163865

Vancouver

Fonseca Brito L, Brune W, Stahl FR. Cytomegalovirus (CMV) Pneumonitis: Cell Tropism, Inflammation, and Immunity. INT J MOL SCI. 2019 Aug 8;20(16):3865. https://doi.org/10.3390/ijms20163865

Bibtex

@article{35a62f7c804843bf8903abbf0e8dc7a9,
title = "Cytomegalovirus (CMV) Pneumonitis: Cell Tropism, Inflammation, and Immunity",
abstract = "Human cytomegalovirus (HCMV) is an opportunistic pathogen causing disease mainly in immunocompromised patients or after congenital infection. HCMV infection of the respiratory tract leads to pneumonitis in the immunocompromised host, which is often associated with a bad clinical course. The related mouse cytomegalovirus (MCMV) likewise exhibits a distinct tropism for the lung and thus provides an elegant model to study host-pathogen interaction. Accordingly, fundamental features of cytomegalovirus (CMV) pneumonitis have been discovered in mice that correlate with clinical data obtained from humans. Recent studies have provided insight into MCMV cell tropism and localized inflammation after infection of the respiratory tract. Accordingly, the nodular inflammatory focus (NIF) has been identified as the anatomical correlate of immune control in lungs. Several hematopoietic cells involved in antiviral immunity reside in NIFs and their key effector molecules have been deciphered. Here, we review what has been learned from the mouse model with focus on the microanatomy of infection sites and antiviral immunity in MCMV pneumonitis.",
author = "{Fonseca Brito}, Lu{\'i}s and Wolfram Brune and Stahl, {Felix R}",
year = "2019",
month = aug,
day = "8",
doi = "10.3390/ijms20163865",
language = "English",
volume = "20",
pages = "3865",
journal = "INT J MOL SCI",
issn = "1661-6596",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "16",

}

RIS

TY - JOUR

T1 - Cytomegalovirus (CMV) Pneumonitis: Cell Tropism, Inflammation, and Immunity

AU - Fonseca Brito, Luís

AU - Brune, Wolfram

AU - Stahl, Felix R

PY - 2019/8/8

Y1 - 2019/8/8

N2 - Human cytomegalovirus (HCMV) is an opportunistic pathogen causing disease mainly in immunocompromised patients or after congenital infection. HCMV infection of the respiratory tract leads to pneumonitis in the immunocompromised host, which is often associated with a bad clinical course. The related mouse cytomegalovirus (MCMV) likewise exhibits a distinct tropism for the lung and thus provides an elegant model to study host-pathogen interaction. Accordingly, fundamental features of cytomegalovirus (CMV) pneumonitis have been discovered in mice that correlate with clinical data obtained from humans. Recent studies have provided insight into MCMV cell tropism and localized inflammation after infection of the respiratory tract. Accordingly, the nodular inflammatory focus (NIF) has been identified as the anatomical correlate of immune control in lungs. Several hematopoietic cells involved in antiviral immunity reside in NIFs and their key effector molecules have been deciphered. Here, we review what has been learned from the mouse model with focus on the microanatomy of infection sites and antiviral immunity in MCMV pneumonitis.

AB - Human cytomegalovirus (HCMV) is an opportunistic pathogen causing disease mainly in immunocompromised patients or after congenital infection. HCMV infection of the respiratory tract leads to pneumonitis in the immunocompromised host, which is often associated with a bad clinical course. The related mouse cytomegalovirus (MCMV) likewise exhibits a distinct tropism for the lung and thus provides an elegant model to study host-pathogen interaction. Accordingly, fundamental features of cytomegalovirus (CMV) pneumonitis have been discovered in mice that correlate with clinical data obtained from humans. Recent studies have provided insight into MCMV cell tropism and localized inflammation after infection of the respiratory tract. Accordingly, the nodular inflammatory focus (NIF) has been identified as the anatomical correlate of immune control in lungs. Several hematopoietic cells involved in antiviral immunity reside in NIFs and their key effector molecules have been deciphered. Here, we review what has been learned from the mouse model with focus on the microanatomy of infection sites and antiviral immunity in MCMV pneumonitis.

U2 - 10.3390/ijms20163865

DO - 10.3390/ijms20163865

M3 - SCORING: Review article

C2 - 31398860

VL - 20

SP - 3865

JO - INT J MOL SCI

JF - INT J MOL SCI

SN - 1661-6596

IS - 16

ER -