Cytokine expression in three mouse models of experimental hepatitis.
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Cytokine expression in three mouse models of experimental hepatitis. / Sass, Gabriele; Heinlein, Sonja; Agli, Andrea; Bang, Renate; Schümann, Jens; Tiegs, Gisa.
In: CYTOKINE, Vol. 19, No. 3, 3, 2002, p. 115-120.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Cytokine expression in three mouse models of experimental hepatitis.
AU - Sass, Gabriele
AU - Heinlein, Sonja
AU - Agli, Andrea
AU - Bang, Renate
AU - Schümann, Jens
AU - Tiegs, Gisa
PY - 2002
Y1 - 2002
N2 - The activation of T-cells and macrophages and subsequent induction of cytokines are critical factors in the development of hepatitis. Up-regulation of pro-inflammatory cytokines, e.g. TNF has been shown to induce liver injury while counter regulation by anti-inflammatory cytokines, e.g. IL-10 is protective. We compared the induction of liver injury and the expression pattern of a variety of cytokines in T-cell- versus non-T-cell-dependent mouse models of liver injury. TNF, IFNgamma, IL-2, IL-4, IL-6, IL-10 and IL-12 were measured in plasma and liver tissue after either Concanavalin A (Con A), D-galactosamine/lipopolysaccharide (GalN/LPS) or high dose LPS induced liver injury. Additionally, the intra-hepatic expression of the putative pathogenicity factor high mobility group 1 protein (HMG-1) was compared in all three models.
AB - The activation of T-cells and macrophages and subsequent induction of cytokines are critical factors in the development of hepatitis. Up-regulation of pro-inflammatory cytokines, e.g. TNF has been shown to induce liver injury while counter regulation by anti-inflammatory cytokines, e.g. IL-10 is protective. We compared the induction of liver injury and the expression pattern of a variety of cytokines in T-cell- versus non-T-cell-dependent mouse models of liver injury. TNF, IFNgamma, IL-2, IL-4, IL-6, IL-10 and IL-12 were measured in plasma and liver tissue after either Concanavalin A (Con A), D-galactosamine/lipopolysaccharide (GalN/LPS) or high dose LPS induced liver injury. Additionally, the intra-hepatic expression of the putative pathogenicity factor high mobility group 1 protein (HMG-1) was compared in all three models.
KW - Animals
KW - Time Factors
KW - Disease Models, Animal
KW - Mice
KW - Mice, Inbred BALB C
KW - Up-Regulation
KW - Kinetics
KW - Reverse Transcriptase Polymerase Chain Reaction
KW - Molecular Sequence Data
KW - Enzyme-Linked Immunosorbent Assay
KW - Interferon-gamma/biosynthesis
KW - Galactosamine/pharmacology
KW - Concanavalin A/pharmacology
KW - Interleukin-6/biosynthesis
KW - Tumor Necrosis Factor-alpha/biosynthesis
KW - Interleukin-10/biosynthesis
KW - Cytokines/biosynthesis/blood
KW - Hepatitis/blood
KW - Interleukin-12/biosynthesis
KW - Interleukin-2/biosynthesis
KW - Interleukin-4/biosynthesis
KW - Lipopolysaccharides/pharmacology
KW - Liver/injuries
KW - Animals
KW - Time Factors
KW - Disease Models, Animal
KW - Mice
KW - Mice, Inbred BALB C
KW - Up-Regulation
KW - Kinetics
KW - Reverse Transcriptase Polymerase Chain Reaction
KW - Molecular Sequence Data
KW - Enzyme-Linked Immunosorbent Assay
KW - Interferon-gamma/biosynthesis
KW - Galactosamine/pharmacology
KW - Concanavalin A/pharmacology
KW - Interleukin-6/biosynthesis
KW - Tumor Necrosis Factor-alpha/biosynthesis
KW - Interleukin-10/biosynthesis
KW - Cytokines/biosynthesis/blood
KW - Hepatitis/blood
KW - Interleukin-12/biosynthesis
KW - Interleukin-2/biosynthesis
KW - Interleukin-4/biosynthesis
KW - Lipopolysaccharides/pharmacology
KW - Liver/injuries
M3 - SCORING: Journal article
VL - 19
SP - 115
EP - 120
JO - CYTOKINE
JF - CYTOKINE
SN - 1043-4666
IS - 3
M1 - 3
ER -
