Cytogenetic aberrations and their prognostic value in a series of 330 splenic marginal zone B-cell lymphomas: a multicenter study of the Splenic B-Cell Lymphoma Group.

TY - JOUR

T1 - Cytogenetic aberrations and their prognostic value in a series of 330 splenic marginal zone B-cell lymphomas: a multicenter study of the Splenic B-Cell Lymphoma Group.

AU - Salido, Marta

AU - Baró, Cristina

AU - Oscier, David

AU - Stamatopoulos, Kostas

AU - Dierlamm, Judith

AU - Matutes, Estela

AU - Traverse-Glehen, Alexandra

AU - Berger, Francoise

AU - Felman, Pascale

AU - Thieblemont, Catherine

AU - Gesk, Stefan

AU - Athanasiadou, Anastasia

AU - Davis, Zadie

AU - Gardiner, Anne

AU - Milla, Fuensanta

AU - Ferrer, Ana

AU - Mollejo, Manuela

AU - Calasanz, Maria José

AU - Florensa, Lourdes

AU - Espinet, Blanca

AU - Luño, Elisa

AU - Wlodarska, Iwona

AU - Verhoef, Gregor

AU - García-Granero, Marta

AU - Salar, Antonio

AU - Papadaki, Theodora

AU - Serrano, Sergio

AU - Piris, Miguel A

AU - Solé, Francesc

PY - 2010

Y1 - 2010

N2 - We conducted a retrospective collaborative study to cytogenetically characterize splenic marginal zone lymphoma (SMZL) and ascertain the prognostic value of chromosomal aberrations. Of 330 cases, 72% displayed an aberrant karyotype, 53% were complex, and 29% had a single aberration. The predominant aberrations were gains of 3/3q and 12q, deletions of 7q and 6q and translocations involving 8q/1q/14q. CD5 expression was detected in 39 of 158 cases (25%). The cytogenetic makeup of the CD5(+) group differed significantly from that of the CD5(-) group. Cases with unmutated IGHV were significantly associated with deletions of 7q and TP53. A strong association was noted between usage of the IGVH1-2 and deletion 7q, 14q alterations, and abnormal karyotype. On univariate analysis, patients with more than or equal to 2 aberrations, 14q alterations, and TP53 deletions had the shortest survival; 7q deletion did not affect survival. On multivariate analysis, cytogenetic aberrations did not retain prognostic significance; the parameters negatively affecting survival were hemoglobin and age. In conclusion, the cytogenetic profile of SMZL is distinct from other B-cell lymphomas. Complexity of the karyotype, 14q aberrations, and TP53 deletions are poor prognostic indicators and may be considered together with other clinicobiologic parameters to ascertain the prognosis of SMZL.

AB - We conducted a retrospective collaborative study to cytogenetically characterize splenic marginal zone lymphoma (SMZL) and ascertain the prognostic value of chromosomal aberrations. Of 330 cases, 72% displayed an aberrant karyotype, 53% were complex, and 29% had a single aberration. The predominant aberrations were gains of 3/3q and 12q, deletions of 7q and 6q and translocations involving 8q/1q/14q. CD5 expression was detected in 39 of 158 cases (25%). The cytogenetic makeup of the CD5(+) group differed significantly from that of the CD5(-) group. Cases with unmutated IGHV were significantly associated with deletions of 7q and TP53. A strong association was noted between usage of the IGVH1-2 and deletion 7q, 14q alterations, and abnormal karyotype. On univariate analysis, patients with more than or equal to 2 aberrations, 14q alterations, and TP53 deletions had the shortest survival; 7q deletion did not affect survival. On multivariate analysis, cytogenetic aberrations did not retain prognostic significance; the parameters negatively affecting survival were hemoglobin and age. In conclusion, the cytogenetic profile of SMZL is distinct from other B-cell lymphomas. Complexity of the karyotype, 14q aberrations, and TP53 deletions are poor prognostic indicators and may be considered together with other clinicobiologic parameters to ascertain the prognosis of SMZL.

M3 - SCORING: Zeitschriftenaufsatz

VL - 116

SP - 1479

EP - 1488

JO - BLOOD

JF - BLOOD

SN - 0006-4971

IS - 9

M1 - 9

ER -