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Cysteine-Based Redox Sensing and Its Role in Signaling by Cyclic Nucleotide-Dependent Kinases in the Cardiovascular System

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Cysteine-Based Redox Sensing and Its Role in Signaling by Cyclic Nucleotide-Dependent Kinases in the Cardiovascular System. / Cuello, Friederike; Eaton, Philip.

In: ANNU REV PHYSIOL, Vol. 81, 10.02.2019, p. 63-87.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Cuello, F & Eaton, P 2019, 'Cysteine-Based Redox Sensing and Its Role in Signaling by Cyclic Nucleotide-Dependent Kinases in the Cardiovascular System', ANNU REV PHYSIOL, vol. 81, pp. 63-87. https://doi.org/10.1146/annurev-physiol-020518-114417

APA

Cuello, F., & Eaton, P. (2019). Cysteine-Based Redox Sensing and Its Role in Signaling by Cyclic Nucleotide-Dependent Kinases in the Cardiovascular System. ANNU REV PHYSIOL, 81, 63-87. https://doi.org/10.1146/annurev-physiol-020518-114417

Vancouver

Cuello F, Eaton P. Cysteine-Based Redox Sensing and Its Role in Signaling by Cyclic Nucleotide-Dependent Kinases in the Cardiovascular System. ANNU REV PHYSIOL. 2019 Feb 10;81:63-87. https://doi.org/10.1146/annurev-physiol-020518-114417

Bibtex

@article{ded652e4a47543ec853d0035f38886fa,
title = "Cysteine-Based Redox Sensing and Its Role in Signaling by Cyclic Nucleotide-Dependent Kinases in the Cardiovascular System",
abstract = "Oxidant molecules are produced in biological systems and historically have been considered causal mediators of damage and disease. While oxidants may contribute to the pathogenesis of disease, evidence continues to emerge that shows these species also play important regulatory roles in health. A major mechanism of oxidant sensing and signaling involves their reaction with reactive cysteine thiols within proteins, inducing oxidative posttranslational modifications that can couple to altered function to enable homeostatic regulation. Protein kinase A and protein kinase G are regulated by oxidants in this way, and this review focuses on our molecular-level understanding of these events and their role in regulating cardiovascular physiology during health and disease.",
keywords = "Journal Article",
author = "Friederike Cuello and Philip Eaton",
year = "2019",
month = feb,
day = "10",
doi = "10.1146/annurev-physiol-020518-114417",
language = "English",
volume = "81",
pages = "63--87",
journal = "ANNU REV PHYSIOL",
issn = "0066-4278",
publisher = "Annual Reviews Inc.",

}

RIS

TY - JOUR

T1 - Cysteine-Based Redox Sensing and Its Role in Signaling by Cyclic Nucleotide-Dependent Kinases in the Cardiovascular System

AU - Cuello, Friederike

AU - Eaton, Philip

PY - 2019/2/10

Y1 - 2019/2/10

N2 - Oxidant molecules are produced in biological systems and historically have been considered causal mediators of damage and disease. While oxidants may contribute to the pathogenesis of disease, evidence continues to emerge that shows these species also play important regulatory roles in health. A major mechanism of oxidant sensing and signaling involves their reaction with reactive cysteine thiols within proteins, inducing oxidative posttranslational modifications that can couple to altered function to enable homeostatic regulation. Protein kinase A and protein kinase G are regulated by oxidants in this way, and this review focuses on our molecular-level understanding of these events and their role in regulating cardiovascular physiology during health and disease.

AB - Oxidant molecules are produced in biological systems and historically have been considered causal mediators of damage and disease. While oxidants may contribute to the pathogenesis of disease, evidence continues to emerge that shows these species also play important regulatory roles in health. A major mechanism of oxidant sensing and signaling involves their reaction with reactive cysteine thiols within proteins, inducing oxidative posttranslational modifications that can couple to altered function to enable homeostatic regulation. Protein kinase A and protein kinase G are regulated by oxidants in this way, and this review focuses on our molecular-level understanding of these events and their role in regulating cardiovascular physiology during health and disease.

KW - Journal Article

U2 - 10.1146/annurev-physiol-020518-114417

DO - 10.1146/annurev-physiol-020518-114417

M3 - SCORING: Review article

C2 - 30216743

VL - 81

SP - 63

EP - 87

JO - ANNU REV PHYSIOL

JF - ANNU REV PHYSIOL

SN - 0066-4278

ER -