Cutting Edge: Regulatory T cells prevent efficient clearance of Mycobacterium tuberculosis.
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Cutting Edge: Regulatory T cells prevent efficient clearance of Mycobacterium tuberculosis. / Kursar, Mischo; Koch, Markus; Mittrücker, Hans Willi; Nouailles, Geraldine; Bonhagen, Kerstin; Kamradt, Thomas; Kaufmann, Stefan H E.
In: J IMMUNOL, Vol. 178, No. 5, 5, 2007, p. 2661-2665.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Cutting Edge: Regulatory T cells prevent efficient clearance of Mycobacterium tuberculosis.
AU - Kursar, Mischo
AU - Koch, Markus
AU - Mittrücker, Hans Willi
AU - Nouailles, Geraldine
AU - Bonhagen, Kerstin
AU - Kamradt, Thomas
AU - Kaufmann, Stefan H E
PY - 2007
Y1 - 2007
N2 - Mycobacterium tuberculosis remains one of the top microbial killers of humans causing approximately 2 million deaths annually. More than 90% of the 2 billion individuals infected never develop active disease, indicating that the immune system is able to generate mechanisms that control infection. However, the immune response generally fails to achieve sterile clearance of bacilli. Using adoptive cell transfer into C57BL/6J-Rag1(tm1Mom) mice (Rag1(-/-)), we show that regulatory T cells prevent eradication of tubercle bacilli by suppressing an otherwise efficient CD4+ T cell response. This protective CD4+ T cell response was not correlated with increased numbers of IFN-gamma- or TNF-alpha-expressing cells or general expression levels of IFN-gamma or inducible NO synthase in infected organs compared with wild-type C57BL/6 animals. Furthermore, suppression of protection by cotransferred regulatory T cells was neither accompanied by a general increase of IL-10 expression nor by higher numbers of IL-10-producing CD4+ T cells.
AB - Mycobacterium tuberculosis remains one of the top microbial killers of humans causing approximately 2 million deaths annually. More than 90% of the 2 billion individuals infected never develop active disease, indicating that the immune system is able to generate mechanisms that control infection. However, the immune response generally fails to achieve sterile clearance of bacilli. Using adoptive cell transfer into C57BL/6J-Rag1(tm1Mom) mice (Rag1(-/-)), we show that regulatory T cells prevent eradication of tubercle bacilli by suppressing an otherwise efficient CD4+ T cell response. This protective CD4+ T cell response was not correlated with increased numbers of IFN-gamma- or TNF-alpha-expressing cells or general expression levels of IFN-gamma or inducible NO synthase in infected organs compared with wild-type C57BL/6 animals. Furthermore, suppression of protection by cotransferred regulatory T cells was neither accompanied by a general increase of IL-10 expression nor by higher numbers of IL-10-producing CD4+ T cells.
M3 - SCORING: Zeitschriftenaufsatz
VL - 178
SP - 2661
EP - 2665
JO - J IMMUNOL
JF - J IMMUNOL
SN - 0022-1767
IS - 5
M1 - 5
ER -
