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Cutaneous na(+) storage strengthens the antimicrobial barrier function of the skin and boosts macrophage-driven host defense

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Cutaneous na(+) storage strengthens the antimicrobial barrier function of the skin and boosts macrophage-driven host defense. / Jantsch, Jonathan; Schatz, Valentin; Friedrich, Diana; Schröder, Agnes; Kopp, Christoph; Siegert, Isabel; Maronna, Andreas; Wendelborn, David; Linz, Peter; Binger, Katrina J; Gebhardt, Matthias; Heinig, Matthias; Neubert, Patrick; Fischer, Fabian; Teufel, Stefan; David, Jean-Pierre; Neufert, Clemens; Cavallaro, Alexander; Rakova, Natalia; Küper, Christoph; Beck, Franz-Xaver; Neuhofer, Wolfgang; Muller, Dominik N; Schuler, Gerold; Uder, Michael; Bogdan, Christian; Luft, Friedrich C; Titze, Jens.

In: CELL METAB, Vol. 21, No. 3, 03.03.2015, p. 493-501.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Jantsch, J, Schatz, V, Friedrich, D, Schröder, A, Kopp, C, Siegert, I, Maronna, A, Wendelborn, D, Linz, P, Binger, KJ, Gebhardt, M, Heinig, M, Neubert, P, Fischer, F, Teufel, S, David, J-P, Neufert, C, Cavallaro, A, Rakova, N, Küper, C, Beck, F-X, Neuhofer, W, Muller, DN, Schuler, G, Uder, M, Bogdan, C, Luft, FC & Titze, J 2015, 'Cutaneous na(+) storage strengthens the antimicrobial barrier function of the skin and boosts macrophage-driven host defense', CELL METAB, vol. 21, no. 3, pp. 493-501. https://doi.org/10.1016/j.cmet.2015.02.003

APA

Jantsch, J., Schatz, V., Friedrich, D., Schröder, A., Kopp, C., Siegert, I., Maronna, A., Wendelborn, D., Linz, P., Binger, K. J., Gebhardt, M., Heinig, M., Neubert, P., Fischer, F., Teufel, S., David, J-P., Neufert, C., Cavallaro, A., Rakova, N., ... Titze, J. (2015). Cutaneous na(+) storage strengthens the antimicrobial barrier function of the skin and boosts macrophage-driven host defense. CELL METAB, 21(3), 493-501. https://doi.org/10.1016/j.cmet.2015.02.003

Vancouver

Jantsch J, Schatz V, Friedrich D, Schröder A, Kopp C, Siegert I et al. Cutaneous na(+) storage strengthens the antimicrobial barrier function of the skin and boosts macrophage-driven host defense. CELL METAB. 2015 Mar 3;21(3):493-501. https://doi.org/10.1016/j.cmet.2015.02.003

Bibtex

@article{6cb52486b85d40cba9c8aaaac1239d94,
title = "Cutaneous na(+) storage strengthens the antimicrobial barrier function of the skin and boosts macrophage-driven host defense",
abstract = "Immune cells regulate a hypertonic microenvironment in the skin; however, the biological advantage of increased skin Na(+) concentrations is unknown. We found that Na(+) accumulated at the site of bacterial skin infections in humans and in mice. We used the protozoan parasite Leishmania major as a model of skin-prone macrophage infection to test the hypothesis that skin-Na(+) storage facilitates antimicrobial host defense. Activation of macrophages in the presence of high NaCl concentrations modified epigenetic markers and enhanced p38 mitogen-activated protein kinase (p38/MAPK)-dependent nuclear factor of activated T cells 5 (NFAT5) activation. This high-salt response resulted in elevated type-2 nitric oxide synthase (Nos2)-dependent NO production and improved Leishmania major control. Finally, we found that increasing Na(+) content in the skin by a high-salt diet boosted activation of macrophages in a Nfat5-dependent manner and promoted cutaneous antimicrobial defense. We suggest that the hypertonic microenvironment could serve as a barrier to infection.",
author = "Jonathan Jantsch and Valentin Schatz and Diana Friedrich and Agnes Schr{\"o}der and Christoph Kopp and Isabel Siegert and Andreas Maronna and David Wendelborn and Peter Linz and Binger, {Katrina J} and Matthias Gebhardt and Matthias Heinig and Patrick Neubert and Fabian Fischer and Stefan Teufel and Jean-Pierre David and Clemens Neufert and Alexander Cavallaro and Natalia Rakova and Christoph K{\"u}per and Franz-Xaver Beck and Wolfgang Neuhofer and Muller, {Dominik N} and Gerold Schuler and Michael Uder and Christian Bogdan and Luft, {Friedrich C} and Jens Titze",
note = "Copyright {\textcopyright} 2015 Elsevier Inc. All rights reserved.",
year = "2015",
month = mar,
day = "3",
doi = "10.1016/j.cmet.2015.02.003",
language = "English",
volume = "21",
pages = "493--501",
journal = "CELL METAB",
issn = "1550-4131",
publisher = "Cell Press",
number = "3",

}

RIS

TY - JOUR

T1 - Cutaneous na(+) storage strengthens the antimicrobial barrier function of the skin and boosts macrophage-driven host defense

AU - Jantsch, Jonathan

AU - Schatz, Valentin

AU - Friedrich, Diana

AU - Schröder, Agnes

AU - Kopp, Christoph

AU - Siegert, Isabel

AU - Maronna, Andreas

AU - Wendelborn, David

AU - Linz, Peter

AU - Binger, Katrina J

AU - Gebhardt, Matthias

AU - Heinig, Matthias

AU - Neubert, Patrick

AU - Fischer, Fabian

AU - Teufel, Stefan

AU - David, Jean-Pierre

AU - Neufert, Clemens

AU - Cavallaro, Alexander

AU - Rakova, Natalia

AU - Küper, Christoph

AU - Beck, Franz-Xaver

AU - Neuhofer, Wolfgang

AU - Muller, Dominik N

AU - Schuler, Gerold

AU - Uder, Michael

AU - Bogdan, Christian

AU - Luft, Friedrich C

AU - Titze, Jens

N1 - Copyright © 2015 Elsevier Inc. All rights reserved.

PY - 2015/3/3

Y1 - 2015/3/3

N2 - Immune cells regulate a hypertonic microenvironment in the skin; however, the biological advantage of increased skin Na(+) concentrations is unknown. We found that Na(+) accumulated at the site of bacterial skin infections in humans and in mice. We used the protozoan parasite Leishmania major as a model of skin-prone macrophage infection to test the hypothesis that skin-Na(+) storage facilitates antimicrobial host defense. Activation of macrophages in the presence of high NaCl concentrations modified epigenetic markers and enhanced p38 mitogen-activated protein kinase (p38/MAPK)-dependent nuclear factor of activated T cells 5 (NFAT5) activation. This high-salt response resulted in elevated type-2 nitric oxide synthase (Nos2)-dependent NO production and improved Leishmania major control. Finally, we found that increasing Na(+) content in the skin by a high-salt diet boosted activation of macrophages in a Nfat5-dependent manner and promoted cutaneous antimicrobial defense. We suggest that the hypertonic microenvironment could serve as a barrier to infection.

AB - Immune cells regulate a hypertonic microenvironment in the skin; however, the biological advantage of increased skin Na(+) concentrations is unknown. We found that Na(+) accumulated at the site of bacterial skin infections in humans and in mice. We used the protozoan parasite Leishmania major as a model of skin-prone macrophage infection to test the hypothesis that skin-Na(+) storage facilitates antimicrobial host defense. Activation of macrophages in the presence of high NaCl concentrations modified epigenetic markers and enhanced p38 mitogen-activated protein kinase (p38/MAPK)-dependent nuclear factor of activated T cells 5 (NFAT5) activation. This high-salt response resulted in elevated type-2 nitric oxide synthase (Nos2)-dependent NO production and improved Leishmania major control. Finally, we found that increasing Na(+) content in the skin by a high-salt diet boosted activation of macrophages in a Nfat5-dependent manner and promoted cutaneous antimicrobial defense. We suggest that the hypertonic microenvironment could serve as a barrier to infection.

U2 - 10.1016/j.cmet.2015.02.003

DO - 10.1016/j.cmet.2015.02.003

M3 - SCORING: Journal article

C2 - 25738463

VL - 21

SP - 493

EP - 501

JO - CELL METAB

JF - CELL METAB

SN - 1550-4131

IS - 3

ER -