Customised reference ranges for umbilical artery Doppler fluximetry according to estimated fetal weight: a prospective longitudinal study
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Customised reference ranges for umbilical artery Doppler fluximetry according to estimated fetal weight: a prospective longitudinal study. / Sirico, A.; Hecher, K.; Schön, G.; Goletzke, J.; Diemert, A.
In: ULTRASOUND OBST GYN, Vol. 54, No. S1, 2019, p. 360-360.Research output: SCORING: Contribution to journal › Conference abstract in journal › Research › peer-review
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TY - JOUR
T1 - Customised reference ranges for umbilical artery Doppler fluximetry according to estimated fetal weight: a prospective longitudinal study
AU - Sirico, A.
AU - Hecher, K.
AU - Schön, G.
AU - Goletzke, J.
AU - Diemert, A.
N1 - doi: 10.1002/uog.21530
PY - 2019
Y1 - 2019
N2 - Objectives: The aim of our study was to establish reference ranges for umbilical artery (UA) Doppler parameters according to estimated fetal weight (EFW). Methods: Data from 549 women participating in the PRINCE study, a prospective low-risk population-based cohort study, were used. UA pulsatility index (PI) and resistance index (RI) values were allocated according to EFW centiles into three groups: small for gestational age (SGA) <10th centile; appropriate for gestational age (AGA) and large for gestational age (LGA) > 90th centile. Fitted regression modeling was performed to evaluate the different distribution of UA Doppler parameters according to the ultrasound gestation week, different EFW groups, fetal sex, week at delivery, the interaction effect of EFW group and ultrasound gestation week and the cluster effect due to repeated measurements in the same patient. Results: We included in our analysis data on 1575 scans performed between 2011 and 2018. Mean UA-PI and UA-RI values in the LGA group were lower than in the AGA and SGA groups (p < 0.001). Longitudinally established percentiles of Doppler indices to EFW groups were calculated. Conclusions: Different reference ranges for UA Doppler parameters according to EFW groups may be useful to not overestimate the risk of fetal distress in constitutionally small fetuses and to highlight increased Doppler resistances in LGA fetuses at values that are considered normal for current published reference ranges.
AB - Objectives: The aim of our study was to establish reference ranges for umbilical artery (UA) Doppler parameters according to estimated fetal weight (EFW). Methods: Data from 549 women participating in the PRINCE study, a prospective low-risk population-based cohort study, were used. UA pulsatility index (PI) and resistance index (RI) values were allocated according to EFW centiles into three groups: small for gestational age (SGA) <10th centile; appropriate for gestational age (AGA) and large for gestational age (LGA) > 90th centile. Fitted regression modeling was performed to evaluate the different distribution of UA Doppler parameters according to the ultrasound gestation week, different EFW groups, fetal sex, week at delivery, the interaction effect of EFW group and ultrasound gestation week and the cluster effect due to repeated measurements in the same patient. Results: We included in our analysis data on 1575 scans performed between 2011 and 2018. Mean UA-PI and UA-RI values in the LGA group were lower than in the AGA and SGA groups (p < 0.001). Longitudinally established percentiles of Doppler indices to EFW groups were calculated. Conclusions: Different reference ranges for UA Doppler parameters according to EFW groups may be useful to not overestimate the risk of fetal distress in constitutionally small fetuses and to highlight increased Doppler resistances in LGA fetuses at values that are considered normal for current published reference ranges.
U2 - 10.1002/uog.21530
DO - 10.1002/uog.21530
M3 - Conference abstract in journal
VL - 54
SP - 360
EP - 360
JO - ULTRASOUND OBST GYN
JF - ULTRASOUND OBST GYN
SN - 0960-7692
IS - S1
ER -
