Current trends and future perspectives of bone substitute materials - from space holders to innovative biomaterials.
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Current trends and future perspectives of bone substitute materials - from space holders to innovative biomaterials. / Kolk, Andreas; Handschel, Jörg; Drescher, Wolf; Rothamel, Daniel; Kloss, Frank; Blessmann, Marco; Heiland, Max; Wolff, Klaus-Dietrich; Smeets, Ralf.
In: J CRANIO MAXILL SURG, Vol. 40, No. 8, 8, 2012, p. 706-718.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Current trends and future perspectives of bone substitute materials - from space holders to innovative biomaterials.
AU - Kolk, Andreas
AU - Handschel, Jörg
AU - Drescher, Wolf
AU - Rothamel, Daniel
AU - Kloss, Frank
AU - Blessmann, Marco
AU - Heiland, Max
AU - Wolff, Klaus-Dietrich
AU - Smeets, Ralf
PY - 2012
Y1 - 2012
N2 - An autologous bone graft is still the ideal material for the repair of craniofacial defects, but its availability is limited and harvesting can be associated with complications. Bone replacement materials as an alternative have a long history of success. With increasing technological advances the spectrum of grafting materials has broadened to allografts, xenografts, and synthetic materials, providing material specific advantages. A large number of bone-graft substitutes are available including allograft bone preparations such as demineralized bone matrix and calcium-based materials. More and more replacement materials consist of one or more components: an osteoconductive matrix, which supports the ingrowth of new bone; and osteoinductive proteins, which sustain mitogenesis of undifferentiated cells; and osteogenic cells (osteoblasts or osteoblast precursors), which are capable of forming bone in the proper environment. All substitutes can either replace autologous bone or expand an existing amount of autologous bone graft. Because an understanding of the properties of each material enables individual treatment concepts this review presents an overview of the principles of bone replacement, the types of graft materials available, and considers future perspectives. Bone substitutes are undergoing a change from a simple replacement material to an individually created composite biomaterial with osteoinductive properties to enable enhanced defect bridging.
AB - An autologous bone graft is still the ideal material for the repair of craniofacial defects, but its availability is limited and harvesting can be associated with complications. Bone replacement materials as an alternative have a long history of success. With increasing technological advances the spectrum of grafting materials has broadened to allografts, xenografts, and synthetic materials, providing material specific advantages. A large number of bone-graft substitutes are available including allograft bone preparations such as demineralized bone matrix and calcium-based materials. More and more replacement materials consist of one or more components: an osteoconductive matrix, which supports the ingrowth of new bone; and osteoinductive proteins, which sustain mitogenesis of undifferentiated cells; and osteogenic cells (osteoblasts or osteoblast precursors), which are capable of forming bone in the proper environment. All substitutes can either replace autologous bone or expand an existing amount of autologous bone graft. Because an understanding of the properties of each material enables individual treatment concepts this review presents an overview of the principles of bone replacement, the types of graft materials available, and considers future perspectives. Bone substitutes are undergoing a change from a simple replacement material to an individually created composite biomaterial with osteoinductive properties to enable enhanced defect bridging.
KW - Humans
KW - Forecasting
KW - Transplantation, Homologous
KW - Ceramics/chemistry
KW - Biocompatible Materials/chemistry/therapeutic use
KW - Biopolymers/chemistry
KW - Bone Matrix/chemistry
KW - Bone Substitutes/chemistry/therapeutic use
KW - Calcium Compounds/chemistry
KW - Tissue Scaffolds/chemistry
KW - Humans
KW - Forecasting
KW - Transplantation, Homologous
KW - Ceramics/chemistry
KW - Biocompatible Materials/chemistry/therapeutic use
KW - Biopolymers/chemistry
KW - Bone Matrix/chemistry
KW - Bone Substitutes/chemistry/therapeutic use
KW - Calcium Compounds/chemistry
KW - Tissue Scaffolds/chemistry
M3 - SCORING: Journal article
VL - 40
SP - 706
EP - 718
JO - J CRANIO MAXILL SURG
JF - J CRANIO MAXILL SURG
SN - 1010-5182
IS - 8
M1 - 8
ER -
