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Current Status of Endovascular Treatment for Acute Large Vessel Occlusion in China: A Real-World Nationwide Registry

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Current Status of Endovascular Treatment for Acute Large Vessel Occlusion in China: A Real-World Nationwide Registry. / Jia, Baixue; Ren, Zeguang; Mokin, Maxim; Burgin, W Scott; Bauer, Clayton T; Fiehler, Jens; Mo, Dapeng; Ma, Ning; Gao, Feng; Huo, Xiaochuan; Luo, Gang; Wang, Anxin; Pan, Yuesong; Song, Ligang; Sun, Xuan; Zhang, Xuelei; Gui, Liqiang; Song, Cunfeng; Peng, Ya; Wu, Jin; Zhao, Shijun; Zhao, Junfeng; Zhou, Zhiming; Li, Yongli; Jing, Ping; Yang, Lei; Liu, Yajie; Zhao, Qingshi; Liu, Yan; Peng, Xiaoxiang; Gao, Qingchun; Guo, Zaiyu; Chen, Wenhuo; Li, Weirong; Cheng, Xiaojiang; Xu, Yun; Zhang, Yongqiang; Zhang, Guilian; Lu, Yijiu; Lu, Xinyu; Wang, Dengxiang; Wang, Yan; Li, Hao; Ling, Li; Peng, Guangge; Zhang, Jingyu; Zhang, Kai; Li, Shuo; Qi, Zhongqi; Xu, Haifeng; Tong, Xu; Ma, Gaoting; Liu, Raynald; Guo, Xu; Deng, Yiming; Leng, Xinyi; Leung, Thomas W; Liebeskind, David S; Wang, Yilong; Wang, Yongjun; Miao, Zhongrong; ANGEL-ACT Study Group†.

In: STROKE, Vol. 52, No. 4, 04.2021, p. 1203-1212.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Jia, B, Ren, Z, Mokin, M, Burgin, WS, Bauer, CT, Fiehler, J, Mo, D, Ma, N, Gao, F, Huo, X, Luo, G, Wang, A, Pan, Y, Song, L, Sun, X, Zhang, X, Gui, L, Song, C, Peng, Y, Wu, J, Zhao, S, Zhao, J, Zhou, Z, Li, Y, Jing, P, Yang, L, Liu, Y, Zhao, Q, Liu, Y, Peng, X, Gao, Q, Guo, Z, Chen, W, Li, W, Cheng, X, Xu, Y, Zhang, Y, Zhang, G, Lu, Y, Lu, X, Wang, D, Wang, Y, Li, H, Ling, L, Peng, G, Zhang, J, Zhang, K, Li, S, Qi, Z, Xu, H, Tong, X, Ma, G, Liu, R, Guo, X, Deng, Y, Leng, X, Leung, TW, Liebeskind, DS, Wang, Y, Wang, Y, Miao, Z & ANGEL-ACT Study Group† 2021, 'Current Status of Endovascular Treatment for Acute Large Vessel Occlusion in China: A Real-World Nationwide Registry', STROKE, vol. 52, no. 4, pp. 1203-1212. https://doi.org/10.1161/STROKEAHA.120.031869

APA

Jia, B., Ren, Z., Mokin, M., Burgin, W. S., Bauer, C. T., Fiehler, J., Mo, D., Ma, N., Gao, F., Huo, X., Luo, G., Wang, A., Pan, Y., Song, L., Sun, X., Zhang, X., Gui, L., Song, C., Peng, Y., ... ANGEL-ACT Study Group† (2021). Current Status of Endovascular Treatment for Acute Large Vessel Occlusion in China: A Real-World Nationwide Registry. STROKE, 52(4), 1203-1212. https://doi.org/10.1161/STROKEAHA.120.031869

Vancouver

Jia B, Ren Z, Mokin M, Burgin WS, Bauer CT, Fiehler J et al. Current Status of Endovascular Treatment for Acute Large Vessel Occlusion in China: A Real-World Nationwide Registry. STROKE. 2021 Apr;52(4):1203-1212. https://doi.org/10.1161/STROKEAHA.120.031869

Bibtex

@article{c5c845055dd44f958efc8836ce4da2c6,
title = "Current Status of Endovascular Treatment for Acute Large Vessel Occlusion in China: A Real-World Nationwide Registry",
abstract = "BACKGROUND AND PURPOSE: The benefit of endovascular treatment (EVT) for large vessel occlusion in clinical practice in developing countries like China needs to be confirmed. The aim of the study was to determine whether the benefit of EVT for acute ischemic stroke in randomized trials could be generalized to clinical practice in Chinese population.METHODS: We conducted a prospective registry of EVT at 111 centers in China. Patients with acute ischemic stroke caused by imaging-confirmed intracranial large vessel occlusion and receiving EVT were included. The primary outcome was functional independence at 90 days defined as a modified Rankin Scale score of 0 to 2. Outcomes of specific subgroups in the anterior circulation were reported and logistic regression was performed to predict the primary outcome.RESULTS: Among the 1793 enrolled patients, 1396 (77.9%) had anterior circulation large vessel occlusion (median age, 66 [56-73] years) and 397 (22.1%) had posterior circulation large vessel occlusion (median age, 64 [55-72] years). Functional independence at 90 days was reached in 45% and 44% in anterior and posterior circulation groups, respectively. For anterior circulation population, underlying intracranial atherosclerotic disease was identified in 29% of patients, with higher functional independence at 90 days (52% versus 44%; P=0.0122) than patients without intracranial atherosclerotic disease. In the anterior circulation population, after adjusting for baseline characteristics, procedure details, and early outcomes, the independent predictors for functional independence at 90 days were age <66 years (odds ratio [OR], 1.733 [95% CI, 1.213-2.476]), time from onset to puncture >6 hours (OR, 1.536 [95% CI, 1.065-2.216]), local anesthesia (OR, 2.194 [95% CI, 1.325-3.633]), final modified Thrombolysis in Cerebral Infarction 2b/3 (OR, 2.052 [95% CI, 1.085-3.878]), puncture-to-reperfusion time ≤1.5 hours (OR, 1.628 [95% CI, 1.098-2.413]), and National Institutes of Health Stroke Scale score 24 hours after the procedure <11 (OR, 9.126 [95% CI, 6.222-13.385]).CONCLUSIONS: Despite distinct characteristics in the Chinese population, favorable outcome of EVT can be achieved in clinical practice in China. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT03370939.",
keywords = "Aged, Cerebrovascular Disorders/complications, China, Endovascular Procedures/methods, Female, Humans, Ischemic Stroke/etiology, Male, Middle Aged, Registries, Treatment Outcome",
author = "Baixue Jia and Zeguang Ren and Maxim Mokin and Burgin, {W Scott} and Bauer, {Clayton T} and Jens Fiehler and Dapeng Mo and Ning Ma and Feng Gao and Xiaochuan Huo and Gang Luo and Anxin Wang and Yuesong Pan and Ligang Song and Xuan Sun and Xuelei Zhang and Liqiang Gui and Cunfeng Song and Ya Peng and Jin Wu and Shijun Zhao and Junfeng Zhao and Zhiming Zhou and Yongli Li and Ping Jing and Lei Yang and Yajie Liu and Qingshi Zhao and Yan Liu and Xiaoxiang Peng and Qingchun Gao and Zaiyu Guo and Wenhuo Chen and Weirong Li and Xiaojiang Cheng and Yun Xu and Yongqiang Zhang and Guilian Zhang and Yijiu Lu and Xinyu Lu and Dengxiang Wang and Yan Wang and Hao Li and Li Ling and Guangge Peng and Jingyu Zhang and Kai Zhang and Shuo Li and Zhongqi Qi and Haifeng Xu and Xu Tong and Gaoting Ma and Raynald Liu and Xu Guo and Yiming Deng and Xinyi Leng and Leung, {Thomas W} and Liebeskind, {David S} and Yilong Wang and Yongjun Wang and Zhongrong Miao and {ANGEL-ACT Study Group†}",
year = "2021",
month = apr,
doi = "10.1161/STROKEAHA.120.031869",
language = "English",
volume = "52",
pages = "1203--1212",
journal = "STROKE",
issn = "0039-2499",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

RIS

TY - JOUR

T1 - Current Status of Endovascular Treatment for Acute Large Vessel Occlusion in China: A Real-World Nationwide Registry

AU - Jia, Baixue

AU - Ren, Zeguang

AU - Mokin, Maxim

AU - Burgin, W Scott

AU - Bauer, Clayton T

AU - Fiehler, Jens

AU - Mo, Dapeng

AU - Ma, Ning

AU - Gao, Feng

AU - Huo, Xiaochuan

AU - Luo, Gang

AU - Wang, Anxin

AU - Pan, Yuesong

AU - Song, Ligang

AU - Sun, Xuan

AU - Zhang, Xuelei

AU - Gui, Liqiang

AU - Song, Cunfeng

AU - Peng, Ya

AU - Wu, Jin

AU - Zhao, Shijun

AU - Zhao, Junfeng

AU - Zhou, Zhiming

AU - Li, Yongli

AU - Jing, Ping

AU - Yang, Lei

AU - Liu, Yajie

AU - Zhao, Qingshi

AU - Liu, Yan

AU - Peng, Xiaoxiang

AU - Gao, Qingchun

AU - Guo, Zaiyu

AU - Chen, Wenhuo

AU - Li, Weirong

AU - Cheng, Xiaojiang

AU - Xu, Yun

AU - Zhang, Yongqiang

AU - Zhang, Guilian

AU - Lu, Yijiu

AU - Lu, Xinyu

AU - Wang, Dengxiang

AU - Wang, Yan

AU - Li, Hao

AU - Ling, Li

AU - Peng, Guangge

AU - Zhang, Jingyu

AU - Zhang, Kai

AU - Li, Shuo

AU - Qi, Zhongqi

AU - Xu, Haifeng

AU - Tong, Xu

AU - Ma, Gaoting

AU - Liu, Raynald

AU - Guo, Xu

AU - Deng, Yiming

AU - Leng, Xinyi

AU - Leung, Thomas W

AU - Liebeskind, David S

AU - Wang, Yilong

AU - Wang, Yongjun

AU - Miao, Zhongrong

AU - ANGEL-ACT Study Group†

PY - 2021/4

Y1 - 2021/4

N2 - BACKGROUND AND PURPOSE: The benefit of endovascular treatment (EVT) for large vessel occlusion in clinical practice in developing countries like China needs to be confirmed. The aim of the study was to determine whether the benefit of EVT for acute ischemic stroke in randomized trials could be generalized to clinical practice in Chinese population.METHODS: We conducted a prospective registry of EVT at 111 centers in China. Patients with acute ischemic stroke caused by imaging-confirmed intracranial large vessel occlusion and receiving EVT were included. The primary outcome was functional independence at 90 days defined as a modified Rankin Scale score of 0 to 2. Outcomes of specific subgroups in the anterior circulation were reported and logistic regression was performed to predict the primary outcome.RESULTS: Among the 1793 enrolled patients, 1396 (77.9%) had anterior circulation large vessel occlusion (median age, 66 [56-73] years) and 397 (22.1%) had posterior circulation large vessel occlusion (median age, 64 [55-72] years). Functional independence at 90 days was reached in 45% and 44% in anterior and posterior circulation groups, respectively. For anterior circulation population, underlying intracranial atherosclerotic disease was identified in 29% of patients, with higher functional independence at 90 days (52% versus 44%; P=0.0122) than patients without intracranial atherosclerotic disease. In the anterior circulation population, after adjusting for baseline characteristics, procedure details, and early outcomes, the independent predictors for functional independence at 90 days were age <66 years (odds ratio [OR], 1.733 [95% CI, 1.213-2.476]), time from onset to puncture >6 hours (OR, 1.536 [95% CI, 1.065-2.216]), local anesthesia (OR, 2.194 [95% CI, 1.325-3.633]), final modified Thrombolysis in Cerebral Infarction 2b/3 (OR, 2.052 [95% CI, 1.085-3.878]), puncture-to-reperfusion time ≤1.5 hours (OR, 1.628 [95% CI, 1.098-2.413]), and National Institutes of Health Stroke Scale score 24 hours after the procedure <11 (OR, 9.126 [95% CI, 6.222-13.385]).CONCLUSIONS: Despite distinct characteristics in the Chinese population, favorable outcome of EVT can be achieved in clinical practice in China. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT03370939.

AB - BACKGROUND AND PURPOSE: The benefit of endovascular treatment (EVT) for large vessel occlusion in clinical practice in developing countries like China needs to be confirmed. The aim of the study was to determine whether the benefit of EVT for acute ischemic stroke in randomized trials could be generalized to clinical practice in Chinese population.METHODS: We conducted a prospective registry of EVT at 111 centers in China. Patients with acute ischemic stroke caused by imaging-confirmed intracranial large vessel occlusion and receiving EVT were included. The primary outcome was functional independence at 90 days defined as a modified Rankin Scale score of 0 to 2. Outcomes of specific subgroups in the anterior circulation were reported and logistic regression was performed to predict the primary outcome.RESULTS: Among the 1793 enrolled patients, 1396 (77.9%) had anterior circulation large vessel occlusion (median age, 66 [56-73] years) and 397 (22.1%) had posterior circulation large vessel occlusion (median age, 64 [55-72] years). Functional independence at 90 days was reached in 45% and 44% in anterior and posterior circulation groups, respectively. For anterior circulation population, underlying intracranial atherosclerotic disease was identified in 29% of patients, with higher functional independence at 90 days (52% versus 44%; P=0.0122) than patients without intracranial atherosclerotic disease. In the anterior circulation population, after adjusting for baseline characteristics, procedure details, and early outcomes, the independent predictors for functional independence at 90 days were age <66 years (odds ratio [OR], 1.733 [95% CI, 1.213-2.476]), time from onset to puncture >6 hours (OR, 1.536 [95% CI, 1.065-2.216]), local anesthesia (OR, 2.194 [95% CI, 1.325-3.633]), final modified Thrombolysis in Cerebral Infarction 2b/3 (OR, 2.052 [95% CI, 1.085-3.878]), puncture-to-reperfusion time ≤1.5 hours (OR, 1.628 [95% CI, 1.098-2.413]), and National Institutes of Health Stroke Scale score 24 hours after the procedure <11 (OR, 9.126 [95% CI, 6.222-13.385]).CONCLUSIONS: Despite distinct characteristics in the Chinese population, favorable outcome of EVT can be achieved in clinical practice in China. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT03370939.

KW - Aged

KW - Cerebrovascular Disorders/complications

KW - China

KW - Endovascular Procedures/methods

KW - Female

KW - Humans

KW - Ischemic Stroke/etiology

KW - Male

KW - Middle Aged

KW - Registries

KW - Treatment Outcome

U2 - 10.1161/STROKEAHA.120.031869

DO - 10.1161/STROKEAHA.120.031869

M3 - SCORING: Journal article

C2 - 33596674

VL - 52

SP - 1203

EP - 1212

JO - STROKE

JF - STROKE

SN - 0039-2499

IS - 4

ER -