Current issues and perspectives in small rodent magnetic resonance imaging using clinical MRI scanners.
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Current issues and perspectives in small rodent magnetic resonance imaging using clinical MRI scanners. / Brockmann, Marc A; Kemmling, Andre; Groden, Christoph.
In: METHODS, Vol. 43, No. 1, 1, 2007, p. 79-87.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Current issues and perspectives in small rodent magnetic resonance imaging using clinical MRI scanners.
AU - Brockmann, Marc A
AU - Kemmling, Andre
AU - Groden, Christoph
PY - 2007
Y1 - 2007
N2 - Small rodents such as mice and rats are frequently used in animal experiments for several reasons. In the past, animal experiments were frequently associated with invasive methods and groups of animals had to be killed to perform longitudinal studies. Today's modern imaging techniques such as magnetic resonance imaging (MRI) allow non-invasive longitudinal monitoring of multiple parameters. Although only a few institutions have access to dedicated small animal MR scanners, most institutions carrying out animal experiments have access to clinical MR scanners. Technological advances and the increasing field strength of clinical scanners make MRI a broadly available and viable technique in preclinical in vivo research. This review provides an overview of current concepts, limitations, and recent studies dealing with small animal imaging using clinical MR scanners.
AB - Small rodents such as mice and rats are frequently used in animal experiments for several reasons. In the past, animal experiments were frequently associated with invasive methods and groups of animals had to be killed to perform longitudinal studies. Today's modern imaging techniques such as magnetic resonance imaging (MRI) allow non-invasive longitudinal monitoring of multiple parameters. Although only a few institutions have access to dedicated small animal MR scanners, most institutions carrying out animal experiments have access to clinical MR scanners. Technological advances and the increasing field strength of clinical scanners make MRI a broadly available and viable technique in preclinical in vivo research. This review provides an overview of current concepts, limitations, and recent studies dealing with small animal imaging using clinical MR scanners.
KW - Animals
KW - Sensitivity and Specificity
KW - Time Factors
KW - Mice
KW - Rats
KW - Magnetic Resonance Spectroscopy
KW - Equipment Design
KW - Abdomen/anatomy & histology/pathology
KW - Body Size
KW - Diagnostic Techniques, Cardiovascular/trends
KW - Diagnostic Techniques, Neurological/trends
KW - Diffusion Magnetic Resonance Imaging/trends
KW - Image Processing, Computer-Assisted/standards
KW - Magnetic Resonance Angiography/trends
KW - Magnetic Resonance Imaging/instrumentation/methods/trends
KW - Rodentia/anatomy & histology
KW - Animals
KW - Sensitivity and Specificity
KW - Time Factors
KW - Mice
KW - Rats
KW - Magnetic Resonance Spectroscopy
KW - Equipment Design
KW - Abdomen/anatomy & histology/pathology
KW - Body Size
KW - Diagnostic Techniques, Cardiovascular/trends
KW - Diagnostic Techniques, Neurological/trends
KW - Diffusion Magnetic Resonance Imaging/trends
KW - Image Processing, Computer-Assisted/standards
KW - Magnetic Resonance Angiography/trends
KW - Magnetic Resonance Imaging/instrumentation/methods/trends
KW - Rodentia/anatomy & histology
M3 - SCORING: Journal article
VL - 43
SP - 79
EP - 87
JO - METHODS
JF - METHODS
SN - 1046-2023
IS - 1
M1 - 1
ER -
