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Crystallization of the EGF receptor ectodomain on US space mission STS-47.

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Crystallization of the EGF receptor ectodomain on US space mission STS-47. / Chr, Betzel; Gunther, N; Poll, S; Moore, K; DeLucas, L J; ChE, Bugg; Weber, Wolfgang.

In: MICROGRAVITY SCI TEC, Vol. 7, No. 3, 3, 1994, p. 242-245.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Chr, B, Gunther, N, Poll, S, Moore, K, DeLucas, LJ, ChE, B & Weber, W 1994, 'Crystallization of the EGF receptor ectodomain on US space mission STS-47.', MICROGRAVITY SCI TEC, vol. 7, no. 3, 3, pp. 242-245. <http://www.ncbi.nlm.nih.gov/pubmed/11541485?dopt=Citation>

APA

Chr, B., Gunther, N., Poll, S., Moore, K., DeLucas, L. J., ChE, B., & Weber, W. (1994). Crystallization of the EGF receptor ectodomain on US space mission STS-47. MICROGRAVITY SCI TEC, 7(3), 242-245. [3]. http://www.ncbi.nlm.nih.gov/pubmed/11541485?dopt=Citation

Vancouver

Chr B, Gunther N, Poll S, Moore K, DeLucas LJ, ChE B et al. Crystallization of the EGF receptor ectodomain on US space mission STS-47. MICROGRAVITY SCI TEC. 1994;7(3):242-245. 3.

Bibtex

@article{8eee71e231fb40fda45d220c86c8983f,
title = "Crystallization of the EGF receptor ectodomain on US space mission STS-47.",
abstract = "Although biochemists working in the field of biological signal transduction have characterized cell surface receptors for numerous growth factors within the past ten years, none of the three-dimensional structures could be obtained for these important proteins which represent major components of the cells' growth control system. Now, the extracellular ligand binding domain of the EGF receptor was crystallized in the presence of EGF under microgravity on US Shuttle mission STS-47. In 8 out of 9 experiments prepared under different conditions crystal growth was observed. One of these space-grown crystals showed higher diffraction quality than all crystals previously obtained in the laboratory. It allowed, for the first time, evaluation of the real space group by partial data collection.",
keywords = "Image Processing, Computer-Assisted, Molecular Structure, Crystallography, X-Ray, Crystallization, Epidermal Growth Factor/*chemistry, Receptor, Epidermal Growth Factor/*chemistry, Space Flight/*instrumentation, *Weightlessness, Image Processing, Computer-Assisted, Molecular Structure, Crystallography, X-Ray, Crystallization, Epidermal Growth Factor/*chemistry, Receptor, Epidermal Growth Factor/*chemistry, Space Flight/*instrumentation, *Weightlessness",
author = "Betzel Chr and N Gunther and S Poll and K Moore and DeLucas, {L J} and Bugg ChE and Wolfgang Weber",
year = "1994",
language = "English",
volume = "7",
pages = "242--245",
journal = "MICROGRAVITY SCI TEC",
issn = "0938-0108",
publisher = "Springer Netherlands",
number = "3",

}

RIS

TY - JOUR

T1 - Crystallization of the EGF receptor ectodomain on US space mission STS-47.

AU - Chr, Betzel

AU - Gunther, N

AU - Poll, S

AU - Moore, K

AU - DeLucas, L J

AU - ChE, Bugg

AU - Weber, Wolfgang

PY - 1994

Y1 - 1994

N2 - Although biochemists working in the field of biological signal transduction have characterized cell surface receptors for numerous growth factors within the past ten years, none of the three-dimensional structures could be obtained for these important proteins which represent major components of the cells' growth control system. Now, the extracellular ligand binding domain of the EGF receptor was crystallized in the presence of EGF under microgravity on US Shuttle mission STS-47. In 8 out of 9 experiments prepared under different conditions crystal growth was observed. One of these space-grown crystals showed higher diffraction quality than all crystals previously obtained in the laboratory. It allowed, for the first time, evaluation of the real space group by partial data collection.

AB - Although biochemists working in the field of biological signal transduction have characterized cell surface receptors for numerous growth factors within the past ten years, none of the three-dimensional structures could be obtained for these important proteins which represent major components of the cells' growth control system. Now, the extracellular ligand binding domain of the EGF receptor was crystallized in the presence of EGF under microgravity on US Shuttle mission STS-47. In 8 out of 9 experiments prepared under different conditions crystal growth was observed. One of these space-grown crystals showed higher diffraction quality than all crystals previously obtained in the laboratory. It allowed, for the first time, evaluation of the real space group by partial data collection.

KW - Image Processing, Computer-Assisted

KW - Molecular Structure

KW - Crystallography, X-Ray

KW - Crystallization

KW - Epidermal Growth Factor/chemistry

KW - Receptor, Epidermal Growth Factor/chemistry

KW - Space Flight/instrumentation

KW - Weightlessness

KW - Image Processing, Computer-Assisted

KW - Molecular Structure

KW - Crystallography, X-Ray

KW - Crystallization

KW - Epidermal Growth Factor/chemistry

KW - Receptor, Epidermal Growth Factor/chemistry

KW - Space Flight/instrumentation

KW - Weightlessness

M3 - SCORING: Journal article

VL - 7

SP - 242

EP - 245

JO - MICROGRAVITY SCI TEC

JF - MICROGRAVITY SCI TEC

SN - 0938-0108

IS - 3

M1 - 3

ER -