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Crosstalk between sentinel and helper macrophages permits neutrophil migration into infected uroepithelium

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Crosstalk between sentinel and helper macrophages permits neutrophil migration into infected uroepithelium. / Schiwon, Marzena; Weisheit, Christina; Franken, Lars; Gutweiler, Sebastian; Dixit, Akanksha; Meyer-Schwesinger, Catherine; Pohl, Judith-Mira; Maurice, Nicholas J; Thiebes, Stephanie; Lorenz, Kristina; Quast, Thomas; Fuhrmann, Martin; Baumgarten, Georg; Lohse, Martin J; Opdenakker, Ghislain; Bernhagen, Jürgen; Bucala, Rick; Panzer, Ulf; Kolanus, Waldemar; Gröne, Hermann-Josef; Garbi, Natalio; Kastenmüller, Wolfgang; Knolle, Percy A; Kurts, Christian; Engel, Daniel R.

In: CELL, Vol. 156, No. 3, 30.01.2014, p. 456-468.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Schiwon, M, Weisheit, C, Franken, L, Gutweiler, S, Dixit, A, Meyer-Schwesinger, C, Pohl, J-M, Maurice, NJ, Thiebes, S, Lorenz, K, Quast, T, Fuhrmann, M, Baumgarten, G, Lohse, MJ, Opdenakker, G, Bernhagen, J, Bucala, R, Panzer, U, Kolanus, W, Gröne, H-J, Garbi, N, Kastenmüller, W, Knolle, PA, Kurts, C & Engel, DR 2014, 'Crosstalk between sentinel and helper macrophages permits neutrophil migration into infected uroepithelium', CELL, vol. 156, no. 3, pp. 456-468. https://doi.org/10.1016/j.cell.2014.01.006

APA

Schiwon, M., Weisheit, C., Franken, L., Gutweiler, S., Dixit, A., Meyer-Schwesinger, C., Pohl, J-M., Maurice, N. J., Thiebes, S., Lorenz, K., Quast, T., Fuhrmann, M., Baumgarten, G., Lohse, M. J., Opdenakker, G., Bernhagen, J., Bucala, R., Panzer, U., Kolanus, W., ... Engel, D. R. (2014). Crosstalk between sentinel and helper macrophages permits neutrophil migration into infected uroepithelium. CELL, 156(3), 456-468. https://doi.org/10.1016/j.cell.2014.01.006

Vancouver

Schiwon M, Weisheit C, Franken L, Gutweiler S, Dixit A, Meyer-Schwesinger C et al. Crosstalk between sentinel and helper macrophages permits neutrophil migration into infected uroepithelium. CELL. 2014 Jan 30;156(3):456-468. https://doi.org/10.1016/j.cell.2014.01.006

Bibtex

@article{77fda4ba9976490c981484e630147cf0,
title = "Crosstalk between sentinel and helper macrophages permits neutrophil migration into infected uroepithelium",
abstract = "The phagocytes of the innate immune system, macrophages and neutrophils, contribute to antibacterial defense, but their functional specialization and cooperation is unclear. Here, we report that three distinct phagocyte subsets play highly coordinated roles in bacterial urinary tract infection. Ly6C(-) macrophages acted as tissue-resident sentinels that attracted circulating neutrophils and Ly6C(+) macrophages. Such Ly6C(+) macrophages played a previously undescribed helper role: once recruited to the site of infection, they produced the cytokine TNF, which caused Ly6C(-) macrophages to secrete CXCL2. This chemokine activated matrix metalloproteinase-9 in neutrophils, allowing their entry into the uroepithelium to combat the bacteria. In summary, the sentinel macrophages elicit the powerful antibacterial functions of neutrophils only after confirmation by the helper macrophages, reminiscent of the licensing role of helper T cells in antiviral adaptive immunity. These findings identify helper macrophages and TNF as critical regulators in innate immunity against bacterial infections in epithelia.",
keywords = "Animals, Antigens, Ly, Bacterial Infections, Chemokine CXCL2, Female, Immune System Diseases, Kinetics, Leukocyte Disorders, Macrophages, Matrix Metalloproteinase 9, Mice, Neutrophils, Specific Pathogen-Free Organisms, Tumor Necrosis Factor-alpha, Urinary Tract Infections",
author = "Marzena Schiwon and Christina Weisheit and Lars Franken and Sebastian Gutweiler and Akanksha Dixit and Catherine Meyer-Schwesinger and Judith-Mira Pohl and Maurice, {Nicholas J} and Stephanie Thiebes and Kristina Lorenz and Thomas Quast and Martin Fuhrmann and Georg Baumgarten and Lohse, {Martin J} and Ghislain Opdenakker and J{\"u}rgen Bernhagen and Rick Bucala and Ulf Panzer and Waldemar Kolanus and Hermann-Josef Gr{\"o}ne and Natalio Garbi and Wolfgang Kastenm{\"u}ller and Knolle, {Percy A} and Christian Kurts and Engel, {Daniel R}",
note = "Copyright {\textcopyright} 2014 Elsevier Inc. All rights reserved.",
year = "2014",
month = jan,
day = "30",
doi = "10.1016/j.cell.2014.01.006",
language = "English",
volume = "156",
pages = "456--468",
journal = "CELL",
issn = "0092-8674",
publisher = "Cell Press",
number = "3",

}

RIS

TY - JOUR

T1 - Crosstalk between sentinel and helper macrophages permits neutrophil migration into infected uroepithelium

AU - Schiwon, Marzena

AU - Weisheit, Christina

AU - Franken, Lars

AU - Gutweiler, Sebastian

AU - Dixit, Akanksha

AU - Meyer-Schwesinger, Catherine

AU - Pohl, Judith-Mira

AU - Maurice, Nicholas J

AU - Thiebes, Stephanie

AU - Lorenz, Kristina

AU - Quast, Thomas

AU - Fuhrmann, Martin

AU - Baumgarten, Georg

AU - Lohse, Martin J

AU - Opdenakker, Ghislain

AU - Bernhagen, Jürgen

AU - Bucala, Rick

AU - Panzer, Ulf

AU - Kolanus, Waldemar

AU - Gröne, Hermann-Josef

AU - Garbi, Natalio

AU - Kastenmüller, Wolfgang

AU - Knolle, Percy A

AU - Kurts, Christian

AU - Engel, Daniel R

N1 - Copyright © 2014 Elsevier Inc. All rights reserved.

PY - 2014/1/30

Y1 - 2014/1/30

N2 - The phagocytes of the innate immune system, macrophages and neutrophils, contribute to antibacterial defense, but their functional specialization and cooperation is unclear. Here, we report that three distinct phagocyte subsets play highly coordinated roles in bacterial urinary tract infection. Ly6C(-) macrophages acted as tissue-resident sentinels that attracted circulating neutrophils and Ly6C(+) macrophages. Such Ly6C(+) macrophages played a previously undescribed helper role: once recruited to the site of infection, they produced the cytokine TNF, which caused Ly6C(-) macrophages to secrete CXCL2. This chemokine activated matrix metalloproteinase-9 in neutrophils, allowing their entry into the uroepithelium to combat the bacteria. In summary, the sentinel macrophages elicit the powerful antibacterial functions of neutrophils only after confirmation by the helper macrophages, reminiscent of the licensing role of helper T cells in antiviral adaptive immunity. These findings identify helper macrophages and TNF as critical regulators in innate immunity against bacterial infections in epithelia.

AB - The phagocytes of the innate immune system, macrophages and neutrophils, contribute to antibacterial defense, but their functional specialization and cooperation is unclear. Here, we report that three distinct phagocyte subsets play highly coordinated roles in bacterial urinary tract infection. Ly6C(-) macrophages acted as tissue-resident sentinels that attracted circulating neutrophils and Ly6C(+) macrophages. Such Ly6C(+) macrophages played a previously undescribed helper role: once recruited to the site of infection, they produced the cytokine TNF, which caused Ly6C(-) macrophages to secrete CXCL2. This chemokine activated matrix metalloproteinase-9 in neutrophils, allowing their entry into the uroepithelium to combat the bacteria. In summary, the sentinel macrophages elicit the powerful antibacterial functions of neutrophils only after confirmation by the helper macrophages, reminiscent of the licensing role of helper T cells in antiviral adaptive immunity. These findings identify helper macrophages and TNF as critical regulators in innate immunity against bacterial infections in epithelia.

KW - Animals

KW - Antigens, Ly

KW - Bacterial Infections

KW - Chemokine CXCL2

KW - Female

KW - Immune System Diseases

KW - Kinetics

KW - Leukocyte Disorders

KW - Macrophages

KW - Matrix Metalloproteinase 9

KW - Mice

KW - Neutrophils

KW - Specific Pathogen-Free Organisms

KW - Tumor Necrosis Factor-alpha

KW - Urinary Tract Infections

U2 - 10.1016/j.cell.2014.01.006

DO - 10.1016/j.cell.2014.01.006

M3 - SCORING: Journal article

C2 - 24485454

VL - 156

SP - 456

EP - 468

JO - CELL

JF - CELL

SN - 0092-8674

IS - 3

ER -